A5085161505- Gut microbiota and health
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Digestive system and related health
- Molecular Biology Techniques and Applications
- Probiotics and Fermented Foods
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Regulation of Appetite and Obesity
- Iron Metabolism and Disorders
- Dialysis and Renal Disease Management
- Infant Nutrition and Health
- Metabolomics and Mass Spectrometry Studies
- Diabetes Management and Research
- Food composition and properties
- interferon and immune responses
- Microbial Metabolites in Food Biotechnology
- Bacteriophages and microbial interactions
- Clinical Nutrition and Gastroenterology
- Advanced Drug Delivery Systems
- Agricultural safety and regulations
- Gastrointestinal motility and disorders
University of Gothenburg
2022-2024
European Food Safety Authority
2024
UCLouvain
2017-2023
Walloon Excellence in Lifesciences and Biotechnology
2019-2023
Abstract Background Leptin-deficient ob/ob mice and leptin receptor-deficient db/db are commonly used models mimicking the conditions of obesity type 2 diabetes development. However, although similarly gaining weight developing massive obesity, more diabetic than mice. It remains still unclear why targeting same pathway—leptin signaling—leads to development two different phenotypes. Given that gut microbes dialogue with host via metabolites (e.g., short-chain fatty acids) but also contribute...
Obesity is a major risk factor for the development of type 2 diabetes and cardiovascular diseases, gut microbiota plays key role in influencing host energy homeostasis. Moreover, obese mice have different composition, associated with an alteration intestinal mucus layer, which represents interface between bacteria host. We previously demonstrated that prebiotic treatment oligofructose (FOS) counteracted effects diet-induced obesity, together changes but it not known if layer could be...
To decipher the mechanisms by which major human milk oligosaccharide (HMO), 2'-fucosyllactose (2'FL), can affect body weight and fat mass gain on high-fat diet (HFD) feeding in mice. We wanted to elucidate whether 2'FL metabolic effects are linked with changes intestinal mucus production secretion, mucin glycosylation degradation, as well modulation of gut microbiota, faecal proteome endocannabinoid (eCB) system.
Obesity and obesity-related disorders, such as type 2 diabetes have been progressively increasing worldwide treatments failed to counteract their progression. Growing evidence demonstrated that gut microbiota is associated with the incidence of these pathologies. Hence, identification new nutritional compounds, able improve health through a modulation microbiota, gaining interest. In this context, aim study was investigate gut-driving effects rhubarb extract in context diet-induced obesity...
To fulfil an unmet therapeutic need for treating type 2 diabetes by developing innovative oral drug delivery nanosystem increasing the production of glucagon-like peptide-1 (GLP-1) and absorption peptides into circulation.We developed a nanocarrier using lipid-based nanocapsules. We encapsulated GLP-1 analogue exenatide within nanocapsules investigated in vitro human L-cells (NCl-H716) murine (GLUTag cells) ability to trigger secretion. The relevance vivo was tested high-fat diet...
Consumption of prebiotics and plant-based compounds have many beneficial health effects through modulation gut microbiota composition are considered as promising nutritional strategy for the treatment metabolic diseases. In present study, we assessed separated combined inulin rhubarb on diet-induced disease in mice. We showed that supplementation with both abolished total body fat mass gain upon high-fat high-sucrose diet (HFHS) well several obesity-associated disorders. These were...
The European Union (EU) is committed to transitioning toward a circular economy model, with food waste being one of the areas be targeted. To close loop generated during processing and discarded at retail or consumption phases, research innovation parties proposed valorize agro-food by-products produce novel foods improvement agents (food additives, enzymes, flavorings). In EU, authorization such governed by different regulatory frameworks. A centralized safety assessment Food Safety...
The aim of this study was to determine the impact different wheat bran fractions on gut microbiota and fat binding capacity explain their differential effects metabolic inflammatory disorders induced by a western diet (WD) in mice. Wheat derived arabinoxylan oligosaccharides (AXOS), crude fraction (WB), or same with reduced particle size (WBs) were added WD mice for 8 weeks. AXOS shifted composition, blunted Clostridium Turicibacter genera strongly promoted Bifidobacterium Butyricicoccus...
We investigated the impact of particle size wheat bran on gut dysbiosis and inflammation induced by a fructose overload. Mice received drinking water with or without (30%) standard diet supplemented 5% fractions characterized different average sizes (1690 µm versus 150 µm) for 8 weeks. Fructose increased Enterobacteriaceae associated higher expression key inflammatory genes in liver. The two differently affected specific bacteria known to be involved regulation barrier function and/or...
To our knowledge, this study is the first to demonstrate that dietary macronutrients (i.e., sugar and fat) have an impact on fecal bacterial cell counting quantitative microbiome profiling in mice. Yet, we fat determining factor promote obesity diabetes progression, local inflammation different body sites. These observations can help disentangle conundrum of detrimental effects habits.
Abstract Background We have previously shown that glycine increases fat‐free mass in chronic haemodialysis patients with features of malnutrition as compared branched‐chain amino acids (BCAAs). This multicentre randomized double‐blind crossover study evaluates the impact these on gut barrier and microbiota. Methods Haemodialysis were included if they had plasma albumin <38 g/L or weight loss >5% dry body weight, daily dietary intakes <30 kcal/kg <1 g protein/kg. They consumed...
The endocannabinoidome (expanded endocannabinoid system, eCBome)-gut microbiome (mBIome) axis plays a fundamental role in the control of energy intake and processing. liver-expressed antimicrobial peptide 2 (LEAP2) is recently identified molecule acting as an antagonist ghrelin receptor hence potential effector metabolism, also at level gastrointestinal system. Here we investigated eCBome-gut mBIome expression LEAP2 liver and, particularly, intestine. We confirm that small intestine strong...
Obesity is associated with a cluster of metabolic disorders, chronic low-grade inflammation, altered gut microbiota, increased intestinal permeability, and alterations the lipid mediators expanded endocannabinoid (eCB) signaling system, or endocannabinoidome (eCBome). In present study, we characterized profile eCBome related oxylipins in small large intestines genetically obese (ob/ob) diabetic (db/db) mice to decipher possible correlations between these inflammation microbiota composition....