A5036558609- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Estrogen and related hormone effects
- Prenatal Substance Exposure Effects
- Dietary Effects on Health
- Neurotransmitter Receptor Influence on Behavior
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Biochemical effects in animals
- Diet and metabolism studies
- PARP inhibition in cancer therapy
- Muscle Physiology and Disorders
- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Alcohol Consumption and Health Effects
National Research Council
2016-2025
Istituto di Chimica Biomolecolare
2015-2025
National Academies of Sciences, Engineering, and Medicine
2013-2024
University of Naples Federico II
2007-2022
Federico II University Hospital
2022
Rothman Institute
2022
Thomas Jefferson University
2022
Rothman Orthopaedics
2022
All India Institute of Medical Sciences Rishikesh
2022
California State University, Long Beach
2022
Epilepsy is the most common neurological disorder, with over 50 million people worldwide affected. Recent evidence suggests that transient receptor potential cation channel subfamily V member 1 (TRPV1) may contribute to onset and progression of some forms epilepsy. Since two nonpsychotropic cannabinoids cannabidivarin (CBDV) cannabidiol (CBD) exert anticonvulsant activity in vivo produce TRPV1-mediated intracellular calcium elevation vitro, we evaluated effects these compounds on TRPV1...
Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal composition along with circulating levels short-chain fatty acids (SCFAs) and related metabolites are altered mdx mouse model Duchenne muscular dystrophy (DMD) compared healthy controls. Supplementation sodium butyrate (NaB) mice rescued strength autophagy, prevented inflammation associated excessive endocannabinoid signaling at CB1 receptors to same extent as...
The endogenous fatty acid amide palmitoylethanolamide (PEA) has been shown to exert anti-inflammatory actions mainly through inhibition of the release pro-inflammatory molecules from mast cells, monocytes and macrophages. Indirect activation endocannabinoid (eCB) system is among several mechanisms action that have proposed underlie different effects PEA in vivo. In this study, we used cultured rat microglia human macrophages evaluate whether affects eCB signaling. was found increase CB2 mRNA...
Abstract Macrophages are pivotal effector cells in immune responses and tissue remodeling by producing a wide spectrum of mediators, including angiogenic lymphangiogenic factors. Activation cannabinoid receptor types 1 2 has been suggested as new strategy to modulate angiogenesis vitro vivo. We investigated whether human lung-resident macrophages express complete endocannabinoid system assessing their production endocannabinoids expression receptors. Unstimulated lung macrophage produce...
Significance Although CB1 cannabinoid receptors control skeletal muscle insulin signaling, little is known of their role in formation during differentiation from myoblasts to myotubes. The voltage-dependent K v 7 + channels, which are tonically activated by the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), instead activate myotube formation. We found that levels endogenous agonist 2-arachidonoylglycerol decreased murine myoblast into myotubes, whereas expression...
The cannabinoid CB2 receptor, which is activated by the endocannabinoid 2-arachidonoyl-glycerol (2-AG), protects striatal neurons from apoptotic death caused local administration of malonate, a rat model Huntington's disease (HD). In present study, we investigated whether endocannabinoids provide tonic neuroprotection in this HD model, examining effect O-3841, an inhibitor diacylglycerol lipases, enzymes that catalyse 2-AG biosynthesis, and JZL184 or OMDM169, two inhibitors inactivation...
Abstract Background Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions. Several mechanisms underlie PEA actions, among which the “entourage” effect, consisting of potentiation endocannabinoid signaling at either cannabinoid receptors or transient receptor potential vanilloid type-1 (TRPV1) channels. Here, we report novel molecular through controls mast...
Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration. Moreover, the associated impairment of autophagy greatly contributes to aggravation damage. We explored possibility using non-euphoric compounds present Cannabis sativa, cannabidiol (CBD), cannabidivarin (CBDV) tetrahydrocannabidivarin (THCV), reduce inflammation, restore functional positively enhance function vivo.Using quantitative PCR, western...
Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in context obesity and associated metabolic disorders. Although a first proof-of-concept its effects has been established syndrome humans, mechanisms are not yet fully understood. This study aimed at deciphering whether bacterium exerts properties through modulation endocannabinoidome (eCBome). Circulating levels 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with...
The endocannabinoid system refers to a widespread signaling and its alteration is implicated in growing number of human diseases. However, the potential role endocannabinoids skeletal muscle disorders remains unknown. Here we report CB1 receptors Duchenne's muscular dystrophy. In murine models, transcripts show highest degree expression at disease onset, then decline overtime. Similar changes are observed for PAX7, key regulator stem cells. Bioinformatics biochemical analysis reveal that...
Abstract The mammalian brain stores and distinguishes among episodic memories, i.e. memories formed during the personal experience, through a mechanism of pattern separation computed in hippocampal dentate gyrus. Decision-making for food-related behaviors, such as choice intake food, might be affected obese subjects by alterations retrieval memories. Adult neurogenesis gyrus regulates separation. Several molecular factors affect adult exert critical role development plasticity newborn...
Abstract Background and Purpose Transient receptor potential melastatin type‐8 (TRPM8) is a cold‐sensitive cation channel protein belonging to the TRP superfamily of ion channels. Here, we reveal molecular mechanism TRPM8 its clinical relevance in colorectal cancer (CRC). Experimental Approach expression correlation with survival rate CRC patients was analysed. To identify key pathways genes related high expression, Kyoto Encyclopedia Genes Genomes pathway enrichment analyses were conducted...