A5044737204- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Cannabis and Cannabinoid Research
- Dietary Effects on Health
- Sleep and related disorders
- Lysosomal Storage Disorders Research
- Diet and metabolism studies
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Herpesvirus Infections and Treatments
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Circadian rhythm and melatonin
- Autism Spectrum Disorder Research
- Neuroscience of respiration and sleep
- Apelin-related biomedical research
- Neurogenesis and neuroplasticity mechanisms
National Research Council
2019-2023
University of Naples Federico II
2019-2021
Institute of Protein Biochemistry
2021
Istituto di Chimica Biomolecolare
2020-2021
Abstract The mammalian brain stores and distinguishes among episodic memories, i.e. memories formed during the personal experience, through a mechanism of pattern separation computed in hippocampal dentate gyrus. Decision-making for food-related behaviors, such as choice intake food, might be affected obese subjects by alterations retrieval memories. Adult neurogenesis gyrus regulates separation. Several molecular factors affect adult exert critical role development plasticity newborn...
Lysosomal storage disorders characterized by altered metabolism of heparan sulfate, including Mucopolysaccharidosis (MPS) III and MPS-II, exhibit lysosomal dysfunctions leading to neurodegeneration dementia in children. In disorders, is preceded severe therapy-resistant autistic-like symptoms unknown cause. Using mouse cellular models MPS-IIIA, we discovered that behaviours are due increased proliferation mesencephalic dopamine neurons originating during embryogenesis, which not dysfunction,...
Toll-like receptors (TLRs) are key through which infectious and non-infectious challenges act with consequent activation of the inflammatory cascade that plays a critical function in various acute chronic diseases, behaving as amplification chronicization factors response. Previous studies have shown synthetic analogues lipid A based on glucosamine few chains unsaturated saturated fatty acids, bind MD-2 inhibit TLR4 receptors. These compounds showed antagonistic activity against vitro by...
In states of intestinal dysbiosis, a perturbation the normal microbiome composition, epithelial barrier (IEB) permeability is increased as result disruption tight junction protein network, in which occludin mostly affected. The loss IEB integrity promotes endotoxemia, that is, bacterial lipopolysaccharide (LPS) translocation from lumen to circulatory system. This condition induces an enhancement pro-inflammatory cytokines, leads neuroinflammation through gut-brain axis. Orexin-A (OX-A),...
Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas the lateral hypothalamus (LH) in brain leptin knockout obese ob/ob mice. In this study, we have investigated whether a similar increase OX-A ventral tegmental area (VTA), an orexinergic LH with functional effects on dopaminergic signaling at mesolimbic circuit. By confocal and correlative light electron microscopy (CLEM) morphological studies coupled molecular, biochemical, pharmacological approaches,...
Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the lateral hypothalamus. It exerts powerful control over brain function and physiology regulating energy homeostasis complex behaviors linked to arousal. Under conditions chronic or acute leptin signaling deficiency, such as in obesity short-term food deprivation, respectively, OX-A become hyperactive promote hyperarousal seeking. However, this leptin-dependent mechanism still mostly unexplored. The endocannabinoid...
The potential, multifaceted therapeutic profile of cannabidiol (CBD), a major constituent derived from the Cannabis sativa plant, covers wide range neurological and psychiatric disorders, ranging anxiety to pediatric epilepsy drug addiction. However, molecular targets responsible for these effects have been only partially identified. In this view, involvement orexin system, key regulator in arousal sleep/wake cycle, motivation reward processes, including addiction, prompted us explore, using...
The 3,5-diiodo-L-thyronine (3,5-T2) is an endogenous metabolite of thyroid hormones, whose administration to rodents fed high-fat diet (HFD) prevents body weight increase and reverts the expression pattern pro-inflammatory factors associated HFD. diet-induced obese (D.I.O.) zebrafish (Danio rerio) has been recently used as experimental model investigate fundamental processes underlying central peripheral obesity-driven inflammation. Herein, we aim understand role 3,5-T2 in regulating...