A5012844231- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Lipid Membrane Structure and Behavior
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Metal-Organic Frameworks: Synthesis and Applications
- Cellular Mechanics and Interactions
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Lysosomal Storage Disorders Research
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Force Microscopy Techniques and Applications
- Cellular transport and secretion
- Advanced Nanomaterials in Catalysis
Forschungszentrum Jülich
2022-2024
RWTH Aachen University
2022-2024
Italian Institute of Technology
2018-2023
University of Naples Federico II
2020-2022
Center for Advanced Biomaterials for Healthcare
2018-2021
Abstract Synaptic plasticity is a fundamental process for neuronal communication and involved in neurodegeneration. This has been recently exploited to inspire the design of next‐generation bioelectronic platforms. Neuromorphic devices have emerged as ideal candidates mimicking brain functionalities, thanks their ionic‐to‐electronic signal transduction, biocompatibility, ability display short‐ long‐term memory biological synapses. However, these still fail bridging gap between electronics...
The dynamic interface between the cellular membrane and 3D nanostructures determines biological processes guides design of novel biomedical devices. Despite fact that recent advancements in fabrication artificial biointerfaces have yielded an enhanced understanding this interface, there remain open questions on how reacts behaves presence sharp objects nanoscale. Here we provide a multifaceted characterization membrane's mechanical stability when closely interacting with high-aspect-ratio...
Abstract Neuromorphic systems that display synaptic conditioning based on biochemical signaling activity have recently been introduced in the form of artificial synapses are model devices to develop tissue‐interfaced platforms. In this regard, biohybrid promise adaptive neuron‐integrated functions. However, these suffer from both molecular cross‐talk as biological neural circuits signal transmission typically involves more than one neuromodulator, and unstable electronics wirings complex...
Neurohybrid systems have gained large attention for their potential as in vitro and vivo platform to interrogate modulate the activity of cells tissue within nervous system. In this scenario organic neuromorphic devices been engineered bioelectronic platforms resemble characteristic neuronal functions. However, aiming a functional communication with cells, material synthesis, surface engineering can yet be exploited optimizing bio-recognition processes at neuromorphic-neuronal hybrid...
Biosensing plays vital roles in multiple fields, including healthcare monitoring, drug screening, disease diagnosis, and environmental pollution control. In recent years, transistor-based devices have been considered to be valid platforms for fast, low-cost sensing of diverse analytes. Without additional functionalization, however, these lack selectivity; several strategies developed the direct immobilization bioreceptors on transistor surface improve detection capabilities. this scenario,...
Lysosomal storage disorders characterized by altered metabolism of heparan sulfate, including Mucopolysaccharidosis (MPS) III and MPS-II, exhibit lysosomal dysfunctions leading to neurodegeneration dementia in children. In disorders, is preceded severe therapy-resistant autistic-like symptoms unknown cause. Using mouse cellular models MPS-IIIA, we discovered that behaviours are due increased proliferation mesencephalic dopamine neurons originating during embryogenesis, which not dysfunction,...
Organic neuromorphic platforms have recently received growing interest for the implementation and integration of hybrid systems, acting as a bridge between biological tissue artificial computing architectures.
Abstract The development of organic artificial synapses that exhibit biomimicry features also may enable a more seamless integration neuroelectronic devices in the nervous system, allowing neuromodulation to be perceived as natural behavior by neuronal cells. Nevertheless, capability interact with both electroactive and non‐electroactive neurotransmitters remains challenge since state‐of‐the‐art mainly rely on oxidation species. Here, study proposes an synapse engineered interaction species...
One of the main challenges in neuroelectronics is implementation electronic platforms able to secure a tight coupling with neuronal cells and achieve an optimal signal noise ratio during stimulation/recording electrophysiological activity. In this context, supported lipid bilayers (SLBs), recapitulating structure dynamicity biological plasma membrane, offer promising biomimetic approach trick recognize device as part their native environment, tightening cell-chip coupling. Among possible...
Schematics of OECT with oxygen sensitive polymer (left) and air-stable (right), showing electrochemical reaction cells cytotoxicity.
Metal-organic frameworks (MOFs) are an emerging class of materials with immense biomedical potential for their unique interactions biological and organic materials. In this work, we select two candidate two-dimensional (2D) MOF systems based on Fe3+ Ni2+ metal centers 2-aminoterephthalate acid ligand (Fe-MOF Ni-MOF) evaluate performance as active interface study cell-interactions. 2D Fe-MOF Ni-MOF were synthesized onto hydroxyl-modified gold glass substrates using a layer-by-layer...