A5089282707- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Microbial Inactivation Methods
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Analytical Chemistry and Sensors
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Molecular Communication and Nanonetworks
- Agricultural economics and policies
- Electrochemical Analysis and Applications
- Electrostatic Discharge in Electronics
- Plasma Applications and Diagnostics
- Organic Electronics and Photovoltaics
- Global Trade and Competitiveness
- Lysosomal Storage Disorders Research
- Microfluidic and Bio-sensing Technologies
- Corrosion Behavior and Inhibition
- Advanced Memory and Neural Computing
- Agriculture Market Analysis Ukraine
- Toxin Mechanisms and Immunotoxins
- Electrodeposition and Electroless Coatings
- Agricultural Economics and Policy
- Planarian Biology and Electrostimulation
- Autoimmune and Inflammatory Disorders Research
Stanford University
2022-2025
Mines Saint-Étienne
2018-2024
BioElectronics (United States)
2022
Abstract Poly(3,4‐ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) is widely used as a coating on microelectrode arrays in order to reduce impedance for both vitro and vivo electrophysiology. In many applications, electrode performance of months years desired; yet, there are few studies date that examine the long‐term stability conducting polymers their devices. Here, PEDOT:PSS microelectrodes examined over period four cell culture media enriched fetal bovine serum. The...
Scalable electronic brain implants with long-term stability and low biological perturbation are crucial technologies for high-quality brain–machine interfaces that can seamlessly access delicate hard-to-reach regions of the brain. Here, we created “NeuroRoots,” a biomimetic multi-channel implant similar dimensions (7 μm wide 1.5 thick), mechanical compliance, spatial distribution as axons in Unlike planar shank implants, these devices consist number individual electrode “roots,” each tendril...
Abstract Poly(3,4‐ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) is a conducting polymer commonly used to coat the electrodes of biomedical devices reduce impedance and improve charge injection. The stimulation performance such depends on coating thickness due volumetric properties polymer. Here, influence PEDOT:PSS impedance, injection, electrode stability examined. results show that stacking spin‐coated layers reliable method control without introducing electronic or...
Transparent microelectrode arrays enable simultaneous electrical recording and optical imaging of neuronal networks in the brain. Electrodes made conducting polymer poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) are transparent; however, device fabrication necessitates specific processes to avoid deterioration organic material. Here, we present an innovative scheme for a neural probe that consists transparent PEDOT:PSS electrodes demonstrate its compatibility...
Abstract Organic mixed ionic‐electronic conductors have emerged as a key material for the development of bioelectronic devices due to their soft mechanical properties, biocompatibility, and high volumetric capacitance. In particular, PEDOT:PSS has become choice because it is highly conductive, easily processible, commercially available. However, dispersible in water, leading delamination films when exposed biological environments. For this reason, chemical cross–linking agents such...
Abstract Minimally invasive electrodes of cellular scale that approach a bio-integrative level neural recording could enable the development scalable brain machine interfaces stably interface with same populations over long period time. In this paper, we designed and created NeuroRoots, bio-mimetic multi-channel implant sharing similar dimension (10µm wide, 1.5µm thick), mechanical flexibility spatial distribution as axon bundles in brain. A simple delivery is reported based on assembly...
Abstract Electroporation or electropermeabilization occurs when cells are exposed to sufficiently high‐pulsed electric fields. This phenomenon is now an important technique facilitate the transmembrane transport of molecules, however, role electrode material and associated electrochemical events remain unclear. Here, it shown that electrical stimulation with PEDOT:PSS‐coated electrodes strongly reduces irreversible reactions otherwise lead changes in pH generation reactive oxygen species....
Abstract Glioblastoma is a highly aggressive brain tumor, very invasive and thus difficult to eradicate with standard oncology therapies. Bioelectric treatments based on pulsed electric fields have proven be successful method treat cancerous tissues. However, they rely stiff electrodes, which cause acute chronic injuries, especially in soft tissues like the brain. Here we demonstrate feasibility of delivering flexible electronics using an ovo vascularized tumor model. We show fluorescence...
Safe and long-term electrical stimulation of neurons requires charge injection without damaging the electrode tissue. A common strategy to diminish adverse effects includes modification electrodes with materials that increases capacity. Due its high capacitance, conducting polymer PEDOT:PSS is a promising coating material; however, neural performance in terms stability safety remains largely unexplored. Here, PEDOT:PSS-coated platinum (Pt-PEDOT:PSS) microelectrodes are examined for compared...
Schematics of OECT with oxygen sensitive polymer (left) and air-stable (right), showing electrochemical reaction cells cytotoxicity.
Monitoring of impedance changes during electroporation-based treatments can be used to study the biological response and provide feedback regarding treatment progression. However, seamless integration sensing electrodes with setup challenging high limit recording sensitivity as well spatial resolution. Here, we present an all-in-one microchip containing stimulation electrodes, array low impedance, micro-scale for highly sensitive monitoring.An in vitro platform is fabricated integrated...
Organic electrochemical transistors are extensively studied for applications ranging from bioelectronics to analog and neuromorphic computing. Despite significant advances, the fundamental interactions between polymer semiconductor channel electrolyte, which critically determine device performance, remain underexplored. Here, we examine coupling benchmark PEDOT:PSS ionic liquids explain bistable non-volatile behavior observed in OECTs. Using X-ray scattering spectroscopy techniques,...
Land prices in the Netherlands are strongly influenced by technological change agriculture. These effects described applying cost-push innovation hypothesis. outcome of a price formation process. Market behaviour and sampling interval data (annual) require use simultaneous equations approach. The identification demand supply such model is discussed. statistical results models for two regions presented. estimated parameters do not lead to proper empirical supply. Recursive yield better results.
Glioblastoma is difficult to eradicate with standard oncology therapies due its high degree of invasiveness. Bioelectric treatments based on pulsed electric fields (PEFs) are promising for the improvement treatment efficiency. However, they rely rigid electrodes that cause acute and chronic damage, especially in soft tissues such as brain. In this work, flexible electronics were used deliver PEFs tumors biological response was evaluated fluorescent microscopy. Interdigitated gold a thin,...
Glioblastoma is difficult to eradicate with standard oncology therapies due its high degree of invasiveness. Bioelectric treatments based on pulsed electric fields (PEFs) are promising for the improvement treatment efficiency. However, they rely rigid electrodes that cause acute and chronic damage, especially in soft tissues such as brain. In this work, flexible electronics were used deliver PEFs tumors biological response was evaluated fluorescent microscopy. Interdigitated gold a thin,...