A5012210096- Diamond and Carbon-based Materials Research
- Neuroscience and Neural Engineering
- Force Microscopy Techniques and Applications
- Advanced Fiber Laser Technologies
- RNA Interference and Gene Delivery
- Thermal Radiation and Cooling Technologies
- Lipid Membrane Structure and Behavior
- Molecular Junctions and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Photonic and Optical Devices
- Microfluidic and Bio-sensing Technologies
- Nanowire Synthesis and Applications
- Mesoporous Materials and Catalysis
- Mechanical and Optical Resonators
- Advanced Memory and Neural Computing
- Advanced Thermodynamics and Statistical Mechanics
- Neural dynamics and brain function
- Carbon Nanotubes in Composites
- Photoreceptor and optogenetics research
- Semiconductor materials and devices
- Advanced Thermoelectric Materials and Devices
- Crystallization and Solubility Studies
- Graphene research and applications
- Pickering emulsions and particle stabilization
- Conducting polymers and applications
Stanford University
2016-2025
SLAC National Accelerator Laboratory
2014-2024
Materials Science & Engineering
2018-2023
Creative Commons
2022
Rice University
2017
Menlo School
2012-2016
Stanford Medicine
2007-2016
Palo Alto University
2009-2015
California Institute of Technology
2003-2010
Lawrence Livermore National Laboratory
2007-2008
Use of amphiphilic triblock copolymers to direct the organization polymerizing silica species has resulted in preparation well-ordered hexagonal mesoporous structures (SBA-15) with uniform pore sizes up approximately 300 angstroms. The SBA-15 materials are synthesized acidic media produce highly ordered, two-dimensional (space group p6mm) silica-block copolymer mesophases. Calcination at 500 degrees C gives porous unusually large interlattice d spacings 74.5 320 angstroms between (100)...
We describe a general method for producing ultrahigh-density arrays of aligned metal and semiconductor nanowires nanowire circuits. The technique is based on translating thin film growth thickness control into planar wire arrays. Nanowires were fabricated with diameters pitches (center-to-center distances) as small 8 nanometers 16 nanometers, respectively. have high aspect ratios (up to 10(6)), the process can be carried out multiple times produce simple circuits crossed junction density in...
The formation of continuous mesoporous silica films with large periodic cage and pore structures is reported here. authors use low-cost commercially available triblock copolymers poly(ethylene oxide) non-ionic surfactants as the structure-directing agents in conjunction dip-coat processing. In Figure a transmission electron microscope image calcined hexagonal film shown.
Nondestructive introduction of genes, proteins, and small molecules into mammalian cells with high efficiency is a challenging, yet critical, process. Here we demonstrate simple nanoelectroporation platform to achieve highly efficient molecular delivery transfection yields excellent uniformity cell viability. The system built on alumina nanostraws extending from track-etched membrane, forming an array hollow nanowires connected underlying microfluidic channel. Cellular engulfment the...
Conversion of light into direct current is important for applications ranging from energy conversion to photodetection, yet often challenging over broad photon frequencies. Here we show a new architecture based on surface plasmon excitation within metal-insulator-metal device that produces power spatial confinement electron through absorption. Plasmons excited in the upper metal are absorbed, creating high concentration hot electrons which can inject above or tunnel thin insulating barrier,...
Integrating camera chips into neural recording arrays provides a massively parallel brain-machine interface.
The development of in vivo, longitudinal, real-time monitoring devices is an essential step toward continuous, precision health monitoring. Molecularly imprinted polymers (MIPs) are popular sensor capture agents that more robust than antibodies and have been used for sensors, drug delivery, affinity separations, assays, solid-phase extraction. However, MIP sensors typically limited to one-time use due their high binding (>107 M–1) slow-release kinetics (<10–4 μM/sec). To overcome this...
Mesoscopically ordered, transparent silica−surfactant monoliths have been prepared using amphiphilic triblock poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) (PEO−PPO−PEO) copolymer species to organize polymerizing silica networks. The block acts as a structure-directing agent, the aqueous cations partition within hydrophilic regions of self-assembled system and associate preferentially with PEO blocks. Subsequent polymerization precursor under strongly acidic conditions (pH...
We found monochromatic electron photoemission from large-area self-assembled monolayers of a functionalized diamondoid, [121]tetramantane-6-thiol. Photoelectron spectra the diamondoid exhibited peak at low-kinetic energy threshold; up to 68% all emitted electrons were within this single peak. The intensity emission is indicative diamondoids being negative affinity materials. With an distribution width less than 0.5 volts, source may find application in technologies such as microscopy, beam...
Aluminium-incorporated SBA mesoporous materials have been obtained for the first time by direct synthesis; resulting retain hexagonal order and physical properties of purely siliceous SBA-15 present higher catalytic activities in cumene cracking reaction than AlMCM-41 materials.
We demonstrate a surface plasmon-polariton (SPP) waveguide all-optical switch that combines the unique physical properties of small molecules and metallic (plasmonic) nanostructures. The consists pair gratings defined in an aluminum film coated with 65 nm thick layer photochromic (PC) molecules. first grating couples signal beam consisting free space photons to SPPs interact effectively PC These can reversibly be switched between transparent absorbing states using optical pump. In (signal...
Nanomaterials are promising candidates to improve the delivery efficiency and control of active agents such as DNA or drugs directly into cells. Here we demonstrate cell-culture platforms nanotemplated "nanostraws" that pierce cell membrane, providing a permanent fluidic pipeline for direct cytosolic access. Conventional polymeric track-etch culture membranes alumina coated etched produce fields nanostraws with controllable diameter, thickness, height. Small molecules ions were successfully...
Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For oncological applications, nanoparticles must extravasate order to reach tumor cells perform their designated task. However, little understanding exists regarding effect shape on extravasation. Herein we real-time intravital microscopic imaging meticulously examine how two different behave across three murine models. The study quantitatively demonstrates that high-aspect ratio...
Direct access into cells' interiors is essential for biomolecular delivery, gene transfection, and electrical recordings yet challenging due to the cell membrane barrier. Recently, molecular delivery using vertical nanowires (NWs) has been demonstrated introducing biomolecules a large number of cells in parallel. However, microscopic understanding how when penetrate membranes still lacking, degree which actual penetration occurs controversial. Here we present results from mechanical...
Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their physiological counterparts, ontogeny, transcriptional regulation, heterogeneity remains largely unknown, hampering clinical use. High-dimensional techniques were elucidate transcriptional, phenotypic, functional differences between human vivo mononuclear phagocytes facilitate full potential the clinic. We demonstrate that monocytes...
In this letter, we calculate numerically the emitter-collector gaps that maximize power conversion efficiency of vacuum thermionic energy converters (TECs). The optimum arises because drops both at very large gaps, due to space-charge limitations on TEC current, and small increased parasitic heat loss via near-field radiative transfer. For typical TECs made with cesiated tungsten electrodes, optimal range from 900 nm 3 μm are approximately equal characteristic wavelength emitter thermal...
Quantum emitters are an integral component for a broad range of quantum technologies, including communication, repeaters, and linear optical computation. Solid-state color centers promising candidates scalable optics due to their long coherence time small inhomogeneous broadening. However, once excited, often decay through phonon-assisted processes, limiting the efficiency single-photon generation photon-mediated entanglement generation. Herein, we demonstrate strong enhancement spontaneous...
Significance Cell content analysis has rapidly become one of the most important new tools for measuring cell phenotype and behavior. However, central limitation current sampling technologies is they are destructive must lyse cells to measure contents. This destruction prevents knowledge prior or future states cell, which particularly dynamic processes, such as development differentiation. Here, we show a nondestructive longitudinal platform that can sample repeatedly accurately from same...
Modestly elevating temperature activates minority carrier hopping in BiVO<sub>4</sub>, and dramatically enhances the photoactivity for water oxidation.
Intracellular delivery of mRNA, DNA, and other large macromolecules into cells plays an essential role in array biological research clinical therapies. However, current methods yield a wide variation the amount material delivered, as well limitations on cell types cargoes possible. Here, we demonstrate quantitatively controlled range primary lines with tight dosage distribution using nanostraw-electroporation system (NES). In NES, are cultured onto track-etched membranes protruding...