A5088431726- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Inflammatory mediators and NSAID effects
- Gut microbiota and health
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Silymarin and Mushroom Poisoning
- Probiotics and Fermented Foods
- NF-κB Signaling Pathways
- Advanced Drug Delivery Systems
- Digestive system and related health
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Cancer-related cognitive impairment studies
- Helicobacter pylori-related gastroenterology studies
- Muscle Physiology and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Analytical Chemistry and Chromatography
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
Ceinge Biotecnologie Avanzate (Italy)
2025
University of Naples Federico II
2021-2024
Federico II University Hospital
2023
Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal composition along with circulating levels short-chain fatty acids (SCFAs) and related metabolites are altered mdx mouse model Duchenne muscular dystrophy (DMD) compared healthy controls. Supplementation sodium butyrate (NaB) mice rescued strength autophagy, prevented inflammation associated excessive endocannabinoid signaling at CB1 receptors to same extent as...
Chemotherapy-induced peripheral neuropathy (CIPN) represents one of the most prevalent and potentially disabling side effects due to use anticancer drugs, primary neuropathies detected is induced by administration taxanes, including paclitaxel. It has been demonstrated that gut microbiota crucial for therapeutic effect chemotherapeutic drugs inhibiting tumor growth contributed pathogenesis CIPN. The nutraceuticals receiving growing attention from research community their phytochemical,...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication of antineoplastic drugs, particularly paclitaxel (PTX). It can affect the quality patients' lives and increase risk developing mood disorders. Although several drugs are recommended, they yielded inconclusive results in clinical trials. The aim present work to investigate whether palmitoylethanolamide (PEA) would reduce PTX-induced CIPN associated Moreover, role PPAR-α endocannabinoid system will also be investigated....
Carbohydrates are one of the most abundant and important classes biomolecules. The variety in their structures makes them valuable carriers that can improve pharmaceutical phase, pharmacokinetics pharmacodynamics well-known drugs. D-galactose is a simple, naturally occurring monosaccharide sugar has been extensively studied for use as carrier proven to be this role. With aim validating galactose-prodrug approach, we have investigated galactosylated prodrugs ibuprofen, ketoprofen,...
Several studies show that natural foods are a source of compounds with anticancer properties affect the gut microbiota and its metabolites. In present study, we investigate effect delactosed buffalo milk whey by-product (DMW) on colorectal carcinogenesis.The DMW carcinoma (CRC) was investigated in established mouse model azoxymethane (AOM)-induced colon carcinoma, which closely resembles human clinical condition CRC. The CRC immortalized cell lines also evaluated to further identify...
To improve the biological and toxicological properties of Mefenamic acid (MA), galactosylated prodrug MA named MefeGAL was included in polymeric solid dispersions (PSs) composed poly(glycerol adipate) (PGA) Pluronic® F68 (MefeGAL-PS). MefeGAL-PS compared with formulations (MA-PS) or a mixture equal ratio MefeGAL/MA (Mix-PS). The vitro vivo pharmacological profiles PSs have been investigated. In detail, we evaluated anti-inflammatory (carrageenan-induced paw edema test), analgesic (acetic...
Pain conditions, such as neuropathic pain (NP) and persistent inflammatory are therapeutically difficult to manage. Previous studies have shown the involvement of glutamate receptor in modulation particular same these showed key role AMPA ionotropic subtype. Antiseizure medications (ASMs) often used treat this symptom, however effect perampanel (PER), an ASM acting selective, non-competitive inhibitor on management has not well been investigated yet. Here we tested potential analgesic...
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several antitumor agents resulting in progressive and often irreversible damage nerves. In addition to their known anticancer effects, taxanes, including paclitaxel, can also induce by activating microglia astrocytes, which release pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), chemokine (C-C motif) ligand 2 (CCL-2). All these events contribute the maintenance...
Obesity is a health concern worldwide, and its onset multifactorial. In addition to metabolic syndrome, high-fat diet induces many deleterious downstream effects, such as chronic systemic inflammation, loss of gut barrier integrity, microbial dysbiosis, with reduction butyrate-producing bacteria. These conditions can be ameliorated by increasing legumes in the daily diet. White kidney beans (Phaseolus vulgaris L.) their non-nutritive bioactive component phaseolamin were demonstrated mitigate...
In our previous studies, a ketorolac-galactose conjugate (ketogal) showed prolonged anti-inflammatory and analgesic activity, causing less gastric ulcerogenic effect renal toxicity than its parent drug ketorolac. order to demonstrate the safer profile of ketogal compared ketorolac, histopathological changes in small intestine liver using three staining techniques before after repeated oral administration mice with ketorolac or an equimolecular dose galactosylated prodrug were assessed....