A5015935515- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Neurogenetic and Muscular Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Cannabis and Cannabinoid Research
- Healthcare Systems and Practices
- TGF-β signaling in diseases
- Health, Medicine and Society
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Frailty in Older Adults
- Metabolism, Diabetes, and Cancer
- Genetic Neurodegenerative Diseases
- Growth Hormone and Insulin-like Growth Factors
- Dietary Effects on Health
- Body Contouring and Surgery
UCLouvain
2016-2025
Cliniques Universitaires Saint-Luc
2014-2025
Unité de Nutrition Humaine
2023
Cachexia is a multifactorial syndrome, characterized by the loss of skeletal muscle mass and not fully reversible nutritional support. Recent animal observations suggest that production Activin A (ActA) Myostatin (Mstn) some tumors might contribute to cancer cachexia.Our goal was investigate role ActA Mstn in development human cachexia.The ACTICA study cross-sectional study, which prospectively enrolled patients from tertiary-care center between January 2012 March 2014. Subjects/Outcome...
To investigate the abundance and prevalence of Dysosmobacter welbionis J115T, a novel butyrate-producing bacterium isolated from human gut both in general population subjects with metabolic syndrome. study impact this on host metabolism using diet-induced obese diabetic mice.We analysed presence 11 984 four cohorts (ie, Human Microbiome Project, American Gut Flemish Flora Project Microbes4U). Then, we tested effects daily oral gavages live D. J115T several hallmarks obesity, diabetes,...
BackgroundThe gut microbiota is altered in obesity and strongly influenced by nutrients xenobiotics. We have tested the impact of native inulin as prebiotic present vegetables added a supplement on microbiota-related outcomes obese patients. Metformin treatment was analyzed potential modulator response.MethodsA randomized, single-blinded, multicentric, placebo-controlled trial conducted 150 patients who received 16 g/d versus maltodextrin, coupled to dietary advice consume inulin-rich -poor...
// Laure B. Bindels 1 , Audrey M. Neyrinck Loumaye 2 Emilie Catry Hannah Walgrave Claire Cherbuy 3 Sophie Leclercq 1, 4 Matthias Van Hul 5 Hubert Plovier Barbara Pachikian Luis G. Bermúdez-Humarán Philippe Langella Patrice D. Cani Jean-Paul Thissen and Nathalie Delzenne Metabolism Nutrition Research Group, Louvain Drug Institute, Université Catholique de Louvain, Brussels, Belgium Endocrinology, Diabetology Department, Institut Recherches Expérimentales et Cliniques, Cliniques Universitaires...
Abstract Background Several experimental evidences pinpoint the possible role of Activin A (ActA) as a driver cancer cachexia. Supporting this hypothesis, we showed recently that human cachexia is associated with high ActA levels. Moreover, levels were correlated body weight loss and skeletal muscle density, two prognostic factors in patients. Our goal was therefore to investigate value predict survival Methods Patients colorectal or lung prospectively enrolled at time diagnosis relapse...
Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in context obesity and associated metabolic disorders. Although a first proof-of-concept its effects has been established syndrome humans, mechanisms are not yet fully understood. This study aimed at deciphering whether bacterium exerts properties through modulation endocannabinoidome (eCBome). Circulating levels 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with...
Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling fasting plasma, our study aimed at identifying signatures beneficial properties alive and pasteurized when administrated to cohort insulin-resistant individuals syndrome. Our data highlighted either shared or specific alterations metabolome according form administered respect control group. Common...
Highlights•Enforced expression of Twist1 triggers muscle atrophy•Twist1 is de-repressed in skeletal undergoing cancer cachexia•Twist1 functions Activin/Myostatin signaling to mediate cachexia•Targeting prevents cancer-induced cachexia and prolongs survivalSummaryCancer characterized by extreme loss that results high morbidity mortality. The incidence varies among tumor types, being lowest sarcomas, whereas 90% pancreatic ductal adenocarcinoma (PDAC) patients experience severe weight loss....
Follistatin, a physiological inhibitor of myostatin, induces dramatic increase in skeletal muscle mass, requiring the type 1 IGF-I receptor/Akt/mTOR pathway. The aim present study was to investigate role and insulin, two ligands receptor, follistatin hypertrophic action on muscle. In first step, we showed that increases mass while being associated with downregulation expression. addition, retained its full effect toward hypophysectomized animals despite very low concentrations circulating...
Activin A (ActA) is considered to play a major role in cancer-induced cachexia (CC). Indeed, circulating ActA levels are elevated and predict survival patients with CC. However, the mechanisms by which mediates CC development particular skeletal muscle (SM) atrophy humans not yet fully understood. In this work, we aimed investigate effects of on human SM mouse models We used model cells culture explore how acts towards SM. model, recombinant induced myotube associated decline MyHC-β/slow,...
Tumour progression drives profound alterations in host metabolism, such as adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by cells increases upon acidosis the tumour microenvironment, we reasoned that acids derived from distant lipolysis may sustain craving, leading to loss observed To evaluate pro-lipolytic capacities acid-exposed cells, primary mouse adipocytes subcutaneous and visceral were exposed pH-matched conditioned medium human murine (pH...
Abstract Background Cancer cachexia is a life‐threatening, inflammation‐driven wasting syndrome that remains untreatable. Adiponectin, the most abundant adipokine, plays an important role in several metabolic processes as well inflammation modulation. Our aim was to test whether administration of AdipoRon (AR), synthetic agonist adiponectin receptors, prevents development cancer and its related muscle atrophy. Methods The effect AR on investigated two distinct murine models colorectal...
Loss of skeletal muscle mass in cancer cachexia is recognized as a predictor mortality. This study aimed to characterize the changes secretome associated with gain better understanding mechanisms involved and identify secreted proteins which may reflect this wasting process. The proteome C26 model were investigated by label-free proteomic analysis followed bioinformatic order potentially proteins. Multiple reaction monitoring Western blotting used verify presence candidate circulation. Our...
Our study aims to determine whether myostatin (MSTN) is associated with muscle mass and strength in individuals cancer or obesity, as well cachexia (CC) sarcopenic obesity (SO).