Background: Anacardium occidentale L. is a tropical plant used for the treatment of inflammatory diseases. The goal present work was to investigate anti-inflammatory and anti-oxidant potential oral administration cashew nuts (from L.) in mouse model colitis. Methods: Induction colitis performed by intrarectally injection dinitrobenzene sulfonic acid (DNBS). Cashew were administered daily orally (100 mg/kg) DNBS-injected mice. Results: Four days after DNBS, histological macroscopic colon...

Background: Anacardium occidentale L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of endogenous enzymes such as superoxide dismutase, catalase glutathione, neutrophils infiltration, increase in the activities myeloperoxidase, malondialdehyde, pro-inflammatory release. Methods: Paw edema was induced by subplantar injection carrageenan into right hind paw rats, but 30 min before group animals...

Osteoarthritis is a progressive joint disease characterized by the activation of different molecular mediators, including proinflammatory cytokines, reactive oxygen species, metalloproteinases and nociceptive mediators. Anacardium occidentale L. medicinal plant with anti-oxidative anti-inflammatory properties. In this study we evaluate effects cashew nuts (from L.) oral administration on an experimental model painful degenerative disease. Monosodium iodoacetate (MIA) was intraarticularly...

Palmitoylethanolamide (PEA) is a pleiotropic lipid mediator with established anti-inflammatory and anti-hyperalgesic activity. Ultramicronized PEA (PEA-um) has superior oral efficacy compared to naïve (non-micronized) PEA. The aim of the present study was two-fold: (1) evaluate whether PEA-um greater absorbability PEA, its ability reach peripheral central tissues under healthy local inflammatory conditions (carrageenan paw edema); (2) better characterize molecular pathways involved in...

Diabetic peripheral neuropathy (DPN) is a complication of diabetes connected with morbidity and mortality. DPN presents deterioration nerves pain, feebleness, loss sensation. Particular medications might display their remedial potential by controlling neuroinflammation. Palmitoylethanolamide (PEA) an autacoid local injury antagonist distinguished for its neuroprotective, analgesic, anti-inflammatory properties in numerous experimental models Based on these findings, the goal this work was to...

Fibromyalgia is a chronic condition characterized by increased sensory perception of pain, neuropathic/neurodegenerative modifications, oxidative, and nitrosative stress. An appropriate therapy hard to find, the currently used treatments are able target only one these aspects.The aim this study investigate beneficial effects melatonin plus folic acid administration in rat model reserpine-induced fibromyalgia. Sprague-Dawley male rats were injected with 1 mg/kg reserpine for three consecutive...

Abstract Background Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions. Several mechanisms underlie PEA actions, among which the “entourage” effect, consisting of potentiation endocannabinoid signaling at either cannabinoid receptors or transient receptor potential vanilloid type-1 (TRPV1) channels. Here, we report novel molecular through controls mast...

Diabetes causes various macrovascular and microvascular alterations, often culminating in major clinical complications (first of all, stroke) that lack an effective therapeutic intervention. N-palmitoylethanolamide-oxazoline (PEA-OXA) possesses anti-inflammatory potent neuroprotective effects. Although recent studies have explained the properties PEA-OXA, nothing is known about its effects treating cerebral ischemia. Methods: Focal ischemia was induced by transient middle artery occlusion...

Aflatoxin B1 (AFB1) is a mycotoxin commonly present in feed, characterized by several toxic effects. AFB1 seems to have neurotoxical effect that leads memory impairment behavior. toxicity involves the induction of oxidative stress pathway, rising lipid peroxidation, and it decreases antioxidant enzyme levels. Hence, our research, we wanted evaluate potential protective effects quercetin 30 mg/kg AFB1-mediated brain ameliorative on behavioral alterations. Oral supplementation with increased...

Acute pancreatitis is a severe abdominal pathology often associated with several complications including gut dysfunction. Oxidative stress one of the most important pathways involved in this pathology. Hydroxytyrosol (HT), phenolic compound obtained from olive oil, has shown anti-inflammatory and antioxidant properties. We evaluated effects HT administration on pancreatic intestinal injury induced by caerulein administration. CD1 female mice were administered (50 μg/kg) for 10 h. treatment...

Ischemia/reperfusion injury is a severe disorder associated with high mortality. Several antioxidant and pharmacological properties of cashew nuts (Anacardium occidentale L.) its metabolites from different countries have recently been described. It medicinal plant important therapeutic effects. This study aimed to verify the effect an oral administration in rat model ischemia/reperfusion (I/R). Adult male rats were subjected intestinal I/R by clamping superior mesenteric artery for 30 min...

Chronic rejection is the major leading cause of morbidity and mortality after lung transplantation. Bronchiolitis obliterans syndrome (BOS), a fibroproliferative disorder small airways, main manifestation chronic allograft rejection. We investigated, using transgenic mice, mechanisms through which deficiency IL-1β/IL-18, Casp-1, or Fpr-1 genes could be protective in an experimental model BOS, induced mice by allogeneic heterotopic tracheal KO showed marked reduction histological markers BOS...

Traumatic brain injury (TBI) is a shocking disease frequently followed by behavioral disabilities, including risk of cerebral atrophy and dementia. N-formylpeptide receptor 1 (FPR1) expressed in cells neurons the central nervous system. It involved inflammatory processes during differentiation process neural stem cells. We investigate effect absence Fpr1 gene expression mice subjected to TBI from early stage acute inflammation neurogenesis systematic testing four weeks after injury. C57BL/6...

Background: Chronic pulmonary diseases are characterized by airway remodeling due to complex multicellular responses and the production of free oxygen radicals. They lead a progressive decline functions. Adelmidrol is an analogue palmitoylethanolamide (PEA), which well-known anti-inflammatory anti-oxidant compound. In this study, we investigated efficacy adelmidrol (10 mg/Kg) for bleomycin-induced fibrosis in mice. Methods: Bleomycin intratracheal administration was performed on first day...

Gastric ulcer or peptic is a common disease worldwide. Basically, it develops when there an imbalance between the protective and aggressive factors, especially at luminal surface of epithelial cells. Thus, constant interest in research new drugs for treatment gastric ulcer. The snail secretion dense mucous, that covers external snails, with important functions survival snails. biological proprieties Helix Aspersa Muller mucus has been known centuries to treat human disorders particular skin...

Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play key role in orchestrating this detrimental triad. ALIAmides down-modulate more generally hyperactive cells. Here we investigated safety effectiveness ALIAmide N-palmitoyl-D-glucosamine (PGA) inflammation osteoarthritis pain.Acute toxicity micronized PGA (m-PGA) was assessed rats following OECD Guideline No.425. m-PGA (30...

Background: The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand formyl peptide receptor (FPR) 2/3, a member family phospholipid- and calcium-binding proteins with well-defined role delayed early inhibitory feedback glucocorticoids (GC) pituitary gland implicated occurrence behavioural disorders such as anxiety. Objective: present study aimed to evaluate potential ANXA1 its...

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common devastating clinical disorders with high mortality no specific therapy. Lipopolysaccharide (LPS) is usually used intratracheally to induce ALI in mice. The aim of this study was examine the effects an ultramicronized preparation palmitoylethanolamide (um-PEA) mice subjected LPS-induced ALI. Histopathological analysis reveals that um-PEA reduced alteration after LPS intratracheal administration. Besides,...

Inflammation is known to be an essential trigger of the pathological changes that have a critical impact on nerve repair and regeneration; moreover, damage peripheral nerves can cause loss sensory function produces persistent neuropathic pain. To date, various potential approaches for pain focused controlling neuroinflammation. The aim this study was investigate neuroprotective effects new association ultramicronized Palmitoylethanolamide (PEAum), Autacoid Local Injury Antagonist Amide...

Environmental pollutants may cause adverse effects on the immune system of aquatic organisms. This study revealed that combination environmental and Bisphenol A(BPA) could an acute inflammatory response in zebrafish larvae as shown by body alterations, which imply a common immunotoxicity mechanism for most pollutants. In present we evaluated toxicity after co-exposure BPA Cd or Cr (III) embryos larvae, oxidative stress pathway involved. Evaluation lethal developmental endpoints such...

Fibromyalgia is a chronic condition characterized by persistent widespread pain that significantly reduces quality of life in patients. The purinergic P2X7 receptor (P2X7R) seems to be involved different states and neuroinflammation. purpose this study investigate the positive effects P2X7R inhibition antagonist Brilliant Blue G (BBG) rat model reserpine-induced fibromyalgia. Sprague–Dawley male rats were injected with 1 mg/kg reserpine for three consecutive days. Later, animals administered...

Pharmaceuticals are actually identified as a threat to the ecosystem. Nowadays, growing consumption of antineoplastic agents has been related their continuous input in natural environments. These substances can interfere with physiological and biochemical processes aquatic species over entire life cycle. Oxaliplatin (OXA) is widely used chemotherapeutic agent treat colon or rectal cancer. This study was aimed evaluate developmental toxicity OXA exposure. To this end, zebrafish embryos were...

Vascular dementia (VaD) is the second leading cause of dementia. The majority VaD patients have cognitive abnormalities, which are caused by cerebral hypoperfusion-induced ischemia, endothelial dysfunction, oxidative stress, and neuroinflammation. Natural products receiving increasing attention for treatment neuroinflammatory diseases. aim this study was to investigate molecular pathways underlying protective effects fisetin, a flavonoid present in many fruits vegetables, mouse model induced...