A5050732063- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Ultrasound and Hyperthermia Applications
- Neurological disorders and treatments
- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Lanthanide and Transition Metal Complexes
- Botulinum Toxin and Related Neurological Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Bipolar Disorder and Treatment
- Cardiac Arrhythmias and Treatments
- Electron Spin Resonance Studies
- Prenatal Substance Exposure Effects
- Neurological Disorders and Treatments
- Cannabis and Cannabinoid Research
- Cardiovascular Function and Risk Factors
- Stress Responses and Cortisol
- Heme Oxygenase-1 and Carbon Monoxide
- Developmental and Educational Neuropsychology
Czech Academy of Sciences, Institute of Scientific Instruments
2016-2025
Masaryk University
2016-2025
Brno University of Technology
2016
Although histone acetylation is one of the most widely studied epigenetic modifications, there still a lack information regarding how acetylome regulated during brain development and pathophysiological processes. We demonstrate that embryonic (E15) characterized by an increase in H3K9 as well decreases levels HDAC1 HDAC3. Moreover, experimental induction hyperacetylation led to overexpression NCAM cortex depletion Sox2 subventricular ependyma, which mimicked differentiation Inducing...
Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim this study was to assess perfusion several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker...
Abstract Purpose Focused ultrasound‐induced blood–brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard quantifying induced BBB permeability the parameter, which reflects both and plasma flow. influence of flow can be eliminated by estimating PS parameter. However, this parameter has been largely unexplored in application. This study aims to compare estimates based on focused ultrasound–induced experiments. Methods We used extended Tofts model (ETM)...
Abstract Diffusion kurtosis imaging ( DKI ) by measuring non‐Gaussian diffusion allows an accurate estimation of the distribution water molecule displacement and may correctly characterize microstructural brain changes caused neurodegeneration. The aim this study was to evaluate ability detect induced α‐synuclein (α‐syn) accumulation in α‐syn over‐expressing transgenic mice TNWT ‐61) both gray matter GM white WM using region interest ROI tract‐based spatial statistics analyses, respectively,...
The biomedically focused brain research is largely performed on laboratory mice considering a high homology between the human and mouse genomes. A has an intricate highly complex geometrical structure that hard to display analyse using only 2D methods. Applying some fast efficient methods of visualization in 3D will be crucial for neurobiology future. post-mortem analysis experimental animals' brains usually involves techniques such as magnetic resonance computed tomography. These are...
Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion dopaminergic neurons in the substantia nigra (SN) already died, and first motor symptoms appear. Therefore, tools enabling early PD are essential to identify early-stage patients which neuroprotective treatments could have significant impact. Here, we test utility sensitivity diffusion kurtosis imaging (DKI) detecting progressive microstructural changes several brain regions mice exposed chronic...
Antipsychotics are indispensable in the treatment of severe mental illneses, however adverse metabolic effects including diabetes, weight gain, dyslipidemia, and related cardiovascular morbidity common, current pharmacological strategies for their management unsatisfactory. Glucagon-like 1 peptide receptor agonists (GLP-1 RAs) approved type 2 diabetes obesity hold promise antipsychotic-associated effects. To characterize molecular identify biomarkers GLP-1 RA preventive treatment,...
This paper is focused on quantitative perfusion analysis using MRI and ultrasound. In both ultrasound, most approaches allow estimation of rate constants (Ktrans, kep for MRI) indices (AUC, TTP) that are only related to the physiological parameters a tissue (e.g. blood flow, vessel permeability) but do not their absolute quantification. Recent methods quantification these shortly reviewed. The main problem arterial input function (AIF). summarizes extends current blind-deconvolution AIF...
The aim of this study is to design a method myocardial T1 quantification in small laboratory animals and investigate the effects spatiotemporal regularization needed acquisition duration.We propose compressed-sensing approach based on self-gated inversion-recovery radial two/three-dimensional (2D/3D) golden-angle stack-of-stars with image reconstruction performed using total-variation regularization. was tested phantom healthy rat, as well rats myocardium-remodeling study.The results showed...
Pilot study validating the animal model of depression - bilateral olfactory bulbectomy in rats by two nuclear magnetic resonance methods, indirectly detecting metabolic state brain. Furthermore, focussed on potential differences brain laterality.Arterial spin labelling assessed cerebral flow prefrontal, sensorimotor, and piriform cortices, nucleus accumbens, hippocampus, thalamus, circle Willis, whole Proton spectroscopy provided information about relative metabolite concentrations cortex...
Myocardial remodelling involves structural and functional changes in the heart, potentially leading to heart failure. The deoxycorticosterone acetate (DOCA)/salt model is a widely used experimental approach study hypertension-induced cardiac remodelling. It allows investigate mechanisms underlying myocardial fibrosis hypertrophy, which are key contributors impaired function. In this study, rat acetate/salt was examined over three-week period. experiment involved 11 male Sprague-Dawley rats,...
Quantitative ultrasound perfusion imaging is used to estimate tissue parameters, such as blood flow, volume and mean transit time. The bolus & burst method one possible approach quantitative imaging. It based on a pharmacokinetic model where the intensity curves are modeled convolution of an arterial input function (AIF) impulse residue function. Two AIF models have been presented for so far two lognormal three gamma variate functions. aim this contribution suggest other alternative test...