A5041197546- Cannabis and Cannabinoid Research
- Genetics and Neurodevelopmental Disorders
- Meat and Animal Product Quality
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Animal Nutrition and Physiology
- Fatty Acid Research and Health
- Gut microbiota and health
- Rabbits: Nutrition, Reproduction, Health
- Dietary Effects on Health
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects and Assays
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- RNA modifications and cancer
- Autism Spectrum Disorder Research
- Psychedelics and Drug Studies
- Lipid metabolism and biosynthesis
- Alcohol Consumption and Health Effects
- Lipoproteins and Cardiovascular Health
- Muscle Physiology and Disorders
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
- Peptidase Inhibition and Analysis
- Moringa oleifera research and applications
Université de Sherbrooke
2022-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2020-2023
Université Laval
2020-2023
University of Cagliari
2018-2021
Impact
2021
Sari Agricultural Sciences and Natural Resources University
2016-2019
University of Guilan
2005
Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal composition along with circulating levels short-chain fatty acids (SCFAs) and related metabolites are altered mdx mouse model Duchenne muscular dystrophy (DMD) compared healthy controls. Supplementation sodium butyrate (NaB) mice rescued strength autophagy, prevented inflammation associated excessive endocannabinoid signaling at CB1 receptors to same extent as...
Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to corresponding free fatty acids. Mgll knockout mice (Mgll−/−) exhibit elevated tissue levels MAGs in association with resistance metabolic cardiovascular perturbations induced a high fat diet (HFD). The gut microbiome function are disrupted obesity manner modulated (2-AG’s) main receptors, cannabinoid...
Fragile X Syndrome (FXS) is caused by mutations in the fragile mental retardation 1 gene, characterized low plasma cholesterol levels. Considering essential role of brain signaling and synaptogenesis, it important to screen for abnormalities FXS explore their link with neuropsychological profiles. Brain synthesized situ, excess primarily converted 24(S)-hydroxycholesterol (24(S)-OHC). 27-hydroxycholesterol (27-OHC) major oxidation metabolite that crosses blood-brain barrier from peripheral...
Psychedelics elicit prosocial, antidepressant and anxiolytic effects via neuroplasticity, neurotransmission neuro-immunomodulatory mechanisms. Whether psychedelics affect the brain endocannabinoid system its extended version, endocannabinoidome (eCBome) or gut microbiome, remains unknown.Adult C57BL/6N male mice were administered lysergic acid diethylamide (LSD) saline for 7 days. Sociability was assessed in direct social interaction three chambers tests. Prefrontal cortex hippocampal...
Abstract To evaluate whether a peculiar plasma profile of fatty acids and endocannabinoidome (eCBome)-related mediators may be associated to longevity, we assessed them in octogenarians (Old; n =42) living the east-central mountain area Sardinia, High-Longevity Zone (HLZ), compared sexagenarian (Young; =21) subjects from same area, Olds ( =22) Northern Sardinia indicated as Lower-Longevity (LLZ). We found significant increases conjugated linoleic acid (CLA) heptadecanoic (17:0) levels...
Abstract Background Dyslipidemias, including familial hypercholesterolemia (FH), are a significant risk factor for cardiovascular diseases. FH is genetic disorder resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased probability early disorders. Heterozygous (HeFH) the most common form, affecting approximately 1 250 individuals worldwide, with higher prevalence among French-Canadian population. Childhood critical period screening factors, but...
We investigated the influence of different dietary formulation n-3 polyunsaturated fatty acids (PUFA) on rat tissue acid (FA) incorporation and consequent modulation their bioactive metabolite N-acylethanolamines (NAE). For 10 weeks, rats were fed diets with 12% fat from milk + 4% soybean oil oils PUFA species: as control, linseed rich in α-linolenic (ALA), Buglossoides arvensis ALA stearidonic (SDA), fish eicosapentaenoic (EPA) docosahexaenoic (DHA), Nannochloropsis microalga EPA or...
Fragile X syndrome (FXS) is the most prevalent monogenic cause of intellectual disability and autism spectrum disorder (ASD). Affected individuals have a high prevalence hypocholesterolemia, however, underlying mechanisms clinical significance remains unknown. We hypothesized that decrease in plasma cholesterol levels associated with an alteration content within lipid rafts (LRs) which ultimately affects profile FXS individuals. The platelets LRs were isolated by ultracentrifugation on...
Contents The objective of this study was to consider endocannabinoid system as inflammatory markers in bovine endometrium better understand the role regulating many functions that are related condition. At day 26 post‐partum, fourteen cows were divided into two groups depending on condition: 1‐ subclinical endometritis ( n = 7, with purulent or mucopurulent uterine discharge detectable vagina) and 2‐ healthy No (muco)) discharge. Blood samples collected at 30 days relative calving determine...
Accurate quantification of 24(S)-hydroxycholesterol and 27-hydroxycholesterol holds substantial biological significance due to their involvement in pivotal cellular processes, encompassing cholesterol homeostasis, inflammatory responses, neuronal signaling, potential as disease biomarkers. The plasma determination these oxysterols is challenging considering low concentrations similarities terms empirical formulae, molecular structure, physicochemical properties across all human endogenous...
2 Abstract: This experiment was conducted to evaluate the effects of withdrawing or reduction mineral premix from diets at 21 42 days age on broiler performance. Two hundred and eighty day old chickens Cobb 500 strain used in a completely randomized design with 7 treatments, 4 replicates each. Chickens were fed common starter diet suggested level (0.5%) for first three weeks age. Seven corn-soybean meal based grower different levels 6 The dietary treatments following: T1) 0.5% 4, 5 T2)...
Fragile X Syndrome (FXS) is the most prevalent monogenic cause of Autism Spectrum Disorders (ASDs). Despite a common genetic etiology, affected individuals display heterogenous metabolic abnormalities including hypocholesterolemia. Although changes in metabolism fatty acids (FAs) have been reported various neuropsychiatric disorders, it has not explored humans with FXS. In this study, we investigated FA profiles two different groups: (1) an Argentinian group, FXS and age- sex-matched...
Vitamin D deficiency is associated with poor mental health and dysmetabolism. Several metabolic abnormalities are psychotic diseases, which can be compounded by atypical antipsychotics that induce weight gain insulin resistance. These side-effects may affected vitamin levels. The gut microbiota endocannabinoidome (eCBome) significant regulators of both metabolism health, but their role in the development antipsychotic drug interaction status unknown. We studied effects different combinations...
Abstract High plasma matrix metalloproteases-9 (MMP-9) levels have been reported in Fragile X Syndrome a limited number of animal and human studies. Since the results obtained are method-dependent not directly comparable, clinical utility MMP-9 measurement FXS remains unclear. This study aimed to compare quantitative gel zymography ELISA determine which method better discriminates abnormal individuals with from healthy controls correlates profile. The active total forms were quantified...
Fragile X Syndrome (FXS) results from the silencing of FMR1 gene and is most prevalent inherited cause intellectual disability frequent monogenic autism spectrum disorder. It well established that individuals are subjected to a wide array comorbidities, ranging cognitive, behavioural, medical origin. Furthermore, recent studies have also described metabolic impairments in FXS individuals. However, molecular mechanisms linking FMRP deficiency improper metabolism still misunderstood. The...
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Probiotics represent a promising tool to improve metabolic health, including lipid profiles and cholesterol levels. Modulation of the gut microbiome endocannabinoidome – two interrelated systems involved in several processes influenced by probiotics has been proposed as potential mechanism action. This study establishes impact on microbiota composition mediators an animal model hypercholesterolaemia. Syrian hamsters were fed either low-fat low-cholesterol or high-fat high-cholesterol (HFHC)...
Many studies have been carried out to reduce dietary mineral premix level with no adverse effect on broiler performance. Controversial results reported in this respect. Deyhim et al (1994) showed that at normal temperature and also under heat stress 28-49 days of age, removing vitamin supplements cause reduction performance, but withdrawal alone, didn’t affect production. Christmas (1995) suggest it is possible from finisher diets chickens last week raring period. The aim trail was study...
Dietary n-3 polyunsaturated fatty acids (n-3PUFA) may influence the brain acid (FA) profile and, thereby, biosynthesis of FA bioactive metabolite, such as N-acylethanolamines (NAE). We investigated different dietary formulation n-3PUFA from vegetable or marine oils on rat incorporation and modulation NAE biosynthesis. Rats were fed for 10 weeks with diets containing 12% fat milk + 4% soybean oil PUFA species: control (MilkFat), linseed α-linolenic (ALA) (LSO), Buglossoides arvensis ALA...