A5053360345- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Economic Growth and Development
- Fiscal Policy and Economic Growth
- Neurotransmitter Receptor Influence on Behavior
- Human-Animal Interaction Studies
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- ICT Impact and Policies
- Parkinson's Disease Mechanisms and Treatments
- Plant Stress Responses and Tolerance
- Neuroendocrine regulation and behavior
- Sesquiterpenes and Asteraceae Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Behavior and Welfare Studies
- Income, Poverty, and Inequality
- Economic Growth and Productivity
- Genetic Neurodegenerative Diseases
Ceinge Biotecnologie Avanzate (Italy)
2016-2025
University of Naples Federico II
2016-2025
Federico II University Hospital
2017-2023
Université de Yaoundé I
2021
University of Carthage
2021
Université d'Abomey-Calavi
2021
University of Malawi
2021
African Union
2021
Deutsche Gesellschaft für Internationale Zusammenarbeit
2021
Université Paris 1 Panthéon-Sorbonne
2021
Enhanced supraspinal glutamate levels following nerve injury are associated with pathophysiological mechanisms responsible for neuropathic pain. Chronic pain can interfere specific brain areas involved in glutamate-dependent neuropsychological processes, such as cognition, memory, and decision-making. The medial prefrontal cortex (mPFC) is thought to play a critical role pain-related depression anxiety, which frequent co-morbidities of chronic Using an animal model spared (SNI) the sciatic...
Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. Together with trigger stimulus (human, animal, place, scent, auditory stimuli, objects), experience stressful conditions, either multiple settings or unique situations, more often turning into generalized fear. Such a dysfunctional behavior be associated genetic susceptibility, environmental factors, traumatic experiences, medical conditions. The available...
Since their discovery in the mammalian CNS, d -aspartate and -serine have aroused a strong interest with regard to role as putative neuromodulatory molecules. Whereas functional of an endogenous coagonist NMDA receptors (NMDARs) has been elucidated, biological significance brain is still mostly unclear. In present study, we demonstrated that nonphysiological high levels (1) increased vivo NMDAR activity, (2) attenuated prepulse inhibition deficits induced by amphetamine MK-801...
Interleukin-1β (IL-1β) is involved in mood alterations associated with inflammatory illnesses and stress. The synaptic basis of IL-1β-induced emotional disturbances still unknown. To address the possible involvement endocannabinoid system anxiety, we performed behavioral neurophysiological studies mice exposed to stress or intracerebroventricular injections this cytokine its antagonist. We found that a single injection IL-1β caused anxiety mice, abrogated sensitivity cannabinoid CB1...
The purinergic system is highly involved in the regulation of microglial physiological processes. In addition to accepted roles for P2 X4,7 and Y12 receptors activated by adenosine triphosphate (ATP) diphosphate, respectively, recent evidence suggests a role A2A receptor cytoskeletal rearrangements. However, expression function A1 (A1AR) microglia still unclear. Several reports have demonstrated possible A1AR microglia, but new study has refuted such evidence. this study, we investigated...
Autism spectrum disorders (ASD) are neurodevelopmental conditions characterized by pronounced social and communication deficits stereotyped behaviours. Recent psychosocial neuroimaging studies have highlighted reward-processing reduced dopamine (DA) mesolimbic circuit reactivity in ASD patients. However, the neurobiological molecular determinants of these remain undetermined. Mouse models recapitulating ASD-like phenotypes could help generate hypotheses about origin neurophysiological...
It is long acknowledged that the N-methyl d-aspartate receptor co-agonist, d-serine, plays a crucial role in several receptor-mediated physiological and pathological processes, including schizophrenia. Besides another free d-amino acid, d-aspartate, involved activation of receptors acting as an agonist this subclass, abundantly detected developing human brain. Based on hypothesis hypofunction pathophysiology schizophrenia considering ability d-serine to stimulate receptor-dependent...
The D2/AKT1/GSK-3β signaling pathway has been involved in the downstream intracellular effects of dopamine, pathophysiology cognitive deficits and related brain activity schizophrenia, as well response to treatment with antipsychotics. Polymorphisms D2 ( DRD2 rs1076560) AKT1 rs1130233) genes have associated their respective protein expression higher-order cognition function, including attention. Given strong potential for relationship, we investigated interaction these polymorphisms on...
The volatile constituents of the aerial parts two samples Thymus longicaulis C. Presl, collected in Campania and Sicily, pulegioides L. from same regions, were extracted by hydrodistillation analyzed. Considering four oils together, seventy-eight different compounds identified: 57 for Sicily (91.1% total oil), 40 (91.5% 39 (92.5% oil) 29 (90.1% oil). composition is different, although most abundant components are identical T. pulegioides. essential showed antibacterial activity against eight...
Attention deficit/hyperactivity disorder (ADHD) is characterized by inattention, impulsivity, and motor hyperactivity. Several lines of research support a crucial role for the dopamine transporter ( DAT ) gene in this psychiatric disease. Consistently, most commonly prescribed medications ADHD treatment are stimulant drugs, known to preferentially act on DAT. Recently, knock-in mouse [DAT-cocaine insensitive (DAT-CI)] has been generated carrying cocaine-insensitive that functional but with...
The role of brain-derived neurotrophic factor (BDNF) in emotional processes suggests an interaction with the endocannabinoid system. Here, we addressed functional interplay between BDNF and cannabinoid CB<sub>1</sub> receptors (CB<sub>1</sub>Rs) striatum, a brain area which both CB<sub>1</sub>s play consequences stress rewarding experiences. potently inhibited CB<sub>1</sub>R function through mechanism mediated by altered cholesterol metabolism membrane lipid raft function. effect was...
OBJECTIVE Glycogen synthase kinase 3β (GSK-3β) is an enzyme implicated in neurodevelopmental processes with a broad range of substrates mediating several canonical signaling pathways the brain. The authors investigated association variation GSK-3β gene series progressively more complex phenotypes relevance to schizophrenia, disorder strong genetic risk. METHOD Based on computer predictions, humans functional 1) mRNA expression from postmortem prefrontal cortex, 2) and β-catenin protein...
Increasing evidence points to a role for dysfunctional glutamate N-methyl-D-aspartate receptor (NMDAR) neurotransmission in schizophrenia. D-aspartate is an atypical amino acid that activates NMDARs through binding the site on GluN2 subunits. present high amounts embryonic brain of mammals and rapidly decreases after birth, due activity enzyme oxidase (DDO). The agonistic exerted by its neurodevelopmental occurrence make this D-amino potential mediator some NMDAR-related alterations observed...
N-methyl-d-aspartate receptor (NMDAR) subunit composition strictly commands function and pharmacological responses. Changes in NMDAR have been documented brain disorders such as Parkinson's disease (PD) levodopa (L-DOPA)-induced dyskinesias (LIDs), where an increase of GluN2A/GluN2B ratio at striatal synapses has observed. A therapeutic approach aimed rebalancing synaptic represents a valuable strategy for PD LIDs. To this, the comprehension molecular mechanisms regulating localization...