Marco Perna

ORCID: 0000-0003-4427-273X
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About
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Research Areas
  • Lung Cancer Diagnosis and Treatment
  • Lung Cancer Treatments and Mutations
  • Brain Metastases and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Advanced Radiotherapy Techniques
  • Head and Neck Cancer Studies
  • Lung Cancer Research Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Glioma Diagnosis and Treatment
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cancer Treatment and Pharmacology
  • Colorectal Cancer Treatments and Studies
  • Medical Imaging Techniques and Applications
  • Breast Cancer Treatment Studies
  • COVID-19 and healthcare impacts
  • SARS-CoV-2 and COVID-19 Research
  • Chemotherapy-related skin toxicity
  • Neutropenia and Cancer Infections
  • Myasthenia Gravis and Thymoma
  • Radiopharmaceutical Chemistry and Applications
  • Pituitary Gland Disorders and Treatments
  • Multiple and Secondary Primary Cancers
  • Infection Control and Ventilation
  • Cancer Diagnosis and Treatment
  • Sarcoma Diagnosis and Treatment

Azienda Usl Toscana Centro
2021-2024

Technoport (Luxembourg)
2023

Azienda Ospedaliero-Universitaria Careggi
2017-2022

University of Florence
2017-2022

Ospedale Santa Maria Annunziata
2022

Université de Lorraine
2020

Centre National de la Recherche Scientifique
2020

Institut de Cancérologie de Lorraine
2020

München Klinik
2019

University of Verona
2017

Thymoma is a rare mediastinal neoplasia. Surgery the backbone of treatment, but role postoperative radiotherapy (PORT) remains controversial. We aimed to obtain data on survival and safety in patients treated with PORT three different Italian institutions.We retrospectively analyzed 183 consecutive who underwent surgery from 1981 2015. According Masaoka-Koga staging system, 39.3%, 32.7%, 18.6% 9.8% were stage I, II, III IV disease, respectively. was indicated 114 (62.3%), while 69 subjects...

10.21037/jtd-2019-thym-09 article EN Journal of Thoracic Disease 2020-12-01

Purpose To determine dose constraints that correlate with alopecia in patients treated photon-based Volumetric Modulated Arc Therapy (VMAT) for primary brain tumors. Methods During the treatment planning process, scalp was drawn as a region of interest. Dose received by 0.1 cc (D0.1cc), mean (Dmeanscalp), volumes receiving different doses (V16Gy, V20Gy, V25Gy, V30Gy, V35Gy, V40Gy, and V43Gy) were registered scalp. Alopecia assessed according to Common Terminology Criteria Adverse Events...

10.3389/fonc.2020.00467 article EN cc-by Frontiers in Oncology 2020-04-08

Limited evidence is available concerning the selection criteria and outcomes of platinum unfit newly diagnosed advanced NSCLC patients receiving single-agent chemotherapy. We retrospectively collected data on consecutive, stage IIIB-IV, EGFR/ALK negative PD-L1 < 50% treated with first-line single agent Baseline characteristics, outcome measures toxicities were recorded, as well according to which treatment was made what percentage did not receive a platinum-based Two-hundred twenty-one...

10.3390/cancers14246074 article EN Cancers 2022-12-09

Although the published data about safety of vaccines in patients with cancer are scarce,1Waissengrin B Agbarya A Safadi E Padova H Wolf I Short-term BNT162b2 mRNA COVID-19 vaccine treated immune checkpoint inhibitors.Lancet Oncol. 2021; 22: 581-583Summary Full Text PDF PubMed Scopus (150) Google Scholar National Comprehensive Cancer Network recommends that should be prioritised for vaccination2Recommendations NCCN Vaccination Advisory Committee, version...

10.1016/s1470-2045(21)00427-7 article EN other-oa The Lancet Oncology 2021-08-10

Abstract Background Oral mucositis is a side effect of treatment regimens containing 5‐fluorouracil (5‐FU). The purpose this study was to present our evaluation see if rosiglitazone (RGZ) protected normal tissues from chemotherapy‐induced oral mucositis. Methods C57BL/6J mice were treated with 5‐FU for 5 days, or without RGZ. Mice euthanized after 5, 8, 11, 15 and mucosal segments collected. Results RGZ did not affect the 5‐FU‐induced decrease in mouse body weight. caused loss epithelial...

10.1002/hed.25017 article EN Head & Neck 2017-11-20

Introduction: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment soft tissue sarcoma (STS). Methods: A total 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed high-risk patients. Acute radiotherapy toxicity chemotherapy-related assessed according to Common Terminology Criteria for Adverse Events 4.0; late recorded Radiation Therapy Oncology Group/European...

10.1177/0300891618765565 article EN Tumori Journal 2018-04-11

Afatinib, a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is effective as first-line treatment in patients with EGFR-mutated non-small cell lung cancer (NSCLC). We report 2 cases of locally advanced NSCLC treated neoadjuvant setting EGFR inhibitor at University Florence/Careggi Hospital. In both cases, afatinib was used for up to 3 months, until 1 week before surgery. Both achieved significant reduction (downstaging) the pulmonary mass and...

10.1177/0300891618775204 article EN Tumori Journal 2018-06-13

Concurrent chemotherapy and radiotherapy (cCRT) is considered the standard treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Unfortunately, management still heterogeneous across different specialists. A multidisciplinary approach needed in this setting due to recent, promising results obtained by consolidative immunotherapy. The aim survey assess current LA-NSCLC Italy. From January April 2018, a 15-question focusing on diagnostic/therapeutic was sent 1,478 e-mail...

10.1371/journal.pone.0224027 article EN cc-by PLoS ONE 2019-11-13

In this study, we focused mainly on the metastatic process related to surgery in squamous cell carcinoma of upper aerodigestive tract.We attempted detect isolated cells (CTCs) head and neck (SCCHN) blood stream before, during after surgery.With aim, realized a prospective study analyzing impact CTC level period 9 days.Two widely used techniques were : PCR real time Cell Search.

10.15761/jts.1000335 article EN Journal of Translational Science 2020-01-01
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