A5054986330- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- Radiopharmaceutical Chemistry and Applications
- PARP inhibition in cancer therapy
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Meningioma and schwannoma management
- Chemical Reactions and Isotopes
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
Istituto Oncologico Veneto
2024
University of Genoa
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Ospedale Policlinico San Martino
2021-2024
The treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the advent immune checkpoint inhibitors (ICIs). Despite encouraging results, their efficacy remains limited to a subgroup patients. Circulating checkpoints in soluble (s) form and associated extracellular vesicles (EVs) represent promising markers, especially ICI-based therapeutic settings. We evaluated prognostic role PD-L1 two B7 family members (B7-H3, B7-H4), both EV-associated, cohort advanced NSCLC...
Abstract Purpose: This study aimed to explore metabolic tumor volume (tMTV) as assessed 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT), and understand its biological meaning in patients with NSCLC exposed immune checkpoint blockers(ICBs). Experimental Design: In this study, advanced a positive PET scan within 42 days of first line treatment were enrolled 11 institutions across 4 countries. Total MTV was analyzed, 42% SUVmax threshold. Survival...
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<div>AbstractPurpose:<p>This study aimed to explore metabolic tumor volume (MTV) as assessed by 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG–PET/CT) and understand its biological meaning in patients with non–small cell lung cancer (NSCLC) exposed immune checkpoint blockers (ICB).</p>Experimental Design:<p>In this study, advanced NSCLC a positive PET scan within 42 days of first-line treatment were enrolled 11 institutions across...
Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) clinical motor score, (iii) versus reading by experts.We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted brain DAT SPECT for suspected parkinsonism. Images were post-processed using (Datquant®) (BasGanV2) software. Reading expert the gold standard. A subset of patients pathological or borderline scan evaluated Unified Parkinson's Disease Rating Scale,...
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Data on the use of targeted therapies in glioma are still limited and identification useful targetable mutations is under investigation. Among all relevant alterations identified through next generation sequencing (NGS) tests, ROS1 can rarely be found gliomas, most common them GOPC::ROS1 fusion. Targeted therapies, such as entrectinib, available for alterations. Hereby, case a patient affected by fused glioblastoma treated with entrectinib presented; this achieved complete prolonged response...
Abstract BACKGROUND Patients with rGBM have a dismal prognosis. Nitrosoureas (NS) such as lomustine and fotemustine antiangiogenic drugs regorafenib(Reg) bevacizumab (Bev) are all treatment options for rGBM. No clinical or molecular factors been validated predictors of efficacy to second-line therapy. PTEN mutations common in GBM, but their potential predictive role has understudied. We aim investigate the impact pathogenic alterations on different therapies patients. MATERIAL AND METHODS...
Abstract BACKGROUND NGS panels in oncology offer personalized therapies based on genomic alterations, but data their clinical use and efficacy for non-glioblastoma CNS tumors is limited. MATERIAL AND METHODS This study aimed to explore the molecular landscape of patients (pts) who underwent FoundationOne®CDx testing between 11/2019 04/2023 at Veneto Institute Oncology, Padua (Italy), while also assessing access TT. Analysis was conducted formalin-fixed paraffin-embedded tumor samples,...
Abstract BACKGROUND Nitrosoureas (lomustine/fotemustine) and antiangiogenic drugs (bevacizumab or regorafenib) are second-line treatment options for patients with rGBM, but to date predictors of efficacy lacking. We aimed develop a multi-classification ML algorithm predict the response different second line therapies. MATERIAL AND METHODS conducted retrospective study assess combined predictive value molecular profiles (tested by FoundationOne®CDx on tissue) clinical data...
Abstract BACKGROUND Although less than 5% and 1.5% of glioblastomas (GBM) exhibit the BRAFV600E mutation NRTK fusion, respectively, these cases are significant because some patients (pts) may respond well to BRAF/MEK NTRK inhibitors. Given limited literature, this study aims evaluate efficacy dabrafenib-trametinib larotrectinib in treating adults with recurrent GBM. MATERIAL AND METHODS We retrospectively analyzed a cohort adult pts GBM (WHO 2021) treated 3 italian centers: Veneto Institute...
Abstract Investigating the impact of immune-modulating therapies on mRNA vaccine efficacy transcends immediate context COVID-19 pandemic. This study focuses differential immune responses to third dose among healthy volunteers, cancer patients treated with immune-checkpoint inhibitors (ICIs), and those anti-CD20 antibody rituximab. Utilizing RNA sequencing, serology, interferon-γ release assessment, we charted temporal dynamics response in such cohorts. Our findings indicate that ICIs...