A5043776763- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Prenatal Screening and Diagnostics
- Family Support in Illness
- Genital Health and Disease
- Reproductive Biology and Fertility
- Clinical practice guidelines implementation
- Intraperitoneal and Appendiceal Malignancies
- Resilience and Mental Health
- Menopause: Health Impacts and Treatments
- Urinary and Genital Oncology Studies
- Ethics in medical practice
- Optimism, Hope, and Well-being
- Mental Health and Psychiatry
- Mental Health and Patient Involvement
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- PARP inhibition in cancer therapy
- Hemostasis and retained surgical items
- Male Breast Health Studies
- Melanoma and MAPK Pathways
- Nursing Education, Practice, and Leadership
Cancer Care Ontario
2012-2025
Munster Technological University
2012-2024
Trillium Health Centre
2018-2023
University College Cork
2022
Princess Margaret Cancer Centre
2004-2019
University of Toronto
2001-2018
University Health Network
2002-2016
Gynecologic Oncology Group
2009-2015
Northwick Park Hospital
2014
Ontario Neurotrauma Foundation
2012
The purposes of this study were to estimate the reduction in risk ovarian, fallopian tube, or peritoneal cancer women with a BRCA1 BRCA2 mutation after oophorectomy, by age oophorectomy; impact prophylactic oophorectomy on all-cause mortality; and 5-year survival associated clinically detected occult, cancers diagnosed cohort.Women identified from an international registry; 5,783 completed baseline questionnaire ≥ one follow-up questionnaires. Women observed until either diagnosis cancer,...
PURPOSE: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes regular mammography clinical breast examination, although the effectiveness of these screening techniques in has not been established. The purpose present study was to compare magnetic resonance imaging (MRI) with ultrasound, mammography, physical examination women at high risk hereditary cancer. PATIENTS AND METHODS: A total 196 women, aged 26 59 years, proven or mutations strong family histories ovarian cancer...
Prophylactic oophorectomy (PO) is an option for women at increased risk ovarian carcinoma. In this study the value of intensive pathologic examination PO specimens and accompanying resected tissues in identification occult carcinoma any association with BRCA germline mutation status were ascertained. Specimens from 60 consecutive patients, who not suspected having tumor time surgery, subjected to standardized, complete a prospective over 8-year period. Extra-ovarian examined as well, but...
The prognosis associated with lymph node negative, early stage carcinoma of the cervix is excellent, 5-year survival rates greater than 90%. Radical trachelectomy in combination pelvic dissection (RVT + LPL) has emerged as an alternative to radical hysterectomy (RH) for these patients who desire preservation fertility. However, there are limited data support its efficacy and safety.All patient information was collected prospectively subsequently extracted from cervical cancer surgery...
Abstract Objectives The objective of this study was to measure the impact prophylactic salpingo‐oophorectomy on health‐related quality life and psychological distress in women. Methods Women who underwent between August 20, 2003 June 26, 2008 because a BRCA1 or BRCA2 mutation were invited participate. Participants completed three questionnaires (SF‐12 ® Health Survey, Brief Symptom Inventory Impact Events Scale) before surgery again 1 year after surgery. Measures life, general ovarian cancer...
The aim of this work was to determine molecular characteristics and specifically, the frequency BRAF, C-KIT, NRAS mutations in vulvar vaginal melanomas.A retrospective review all cases melanoma between 2002 2013 performed. We reviewed clinical histological performed genotyping studies on that had tissue available for study, using next-generation sequencing.We identified 33 11 melanomas women with mean ages 58 61 years, respectively. Next-generation sequencing analysis 20 (15 5 vaginal) a...
This study evaluated the psychological side-effects of clomiphene citrate (CC) and hMG in women undergoing fertility treatment.This was a cross-sectional, self-report survey 454 at various stages treatment for infertility. At time study, 139 had not taken drugs 315 one or more cycles CC hMG. All subjects were asked to complete State-Trait Anxiety Inventory (STAI). Women taking also self-administered questionnaire on their medications.In group (n = 162) 153), 77.8% (126 94.8% (145 153)...
The aim of this paper is to assist the novice researcher in research ethics application process. context refers any negotiating a for first time. This may be student or more experienced registered nurse engaged activity. applies ethical principles varied elements form explain theoretical basis criteria. impetus arose following an internal audit decisions made by committee nursing department at Institute Technology Tralee, Ireland. revealed common reasons why full approval was not granted...
WHAT IS KNOWN ON THE SUBJECT?: The delivery of mental health recovery orientated acre is a requirement professionals and an acknowledged desired outcome for individuals presenting with issues. Hope has been recognized as one 5 key processes recovery, critically the catalyst recovery. Mental nurses are required to be competent in cultivating service user hope. PAPER ADDS TO EXISTING KNOWLEDGE?: Novel exploration how people described made sense lived experience hope Participants intrinsic life...
ObjectivesIn Ontario, Canada, the first cohorts who were offered school-based human papillomavirus (HPV) vaccination are now eligible for cervical screening. We determined which screening strategies these populations would result in optimal harms-benefits ratios of screening.MethodsWe used hybrid microsimulation model STDSIM- MISCAN-Cervix to determine harms and cancers prevented 309 different primary HPV strategies, varying by ages triage methods. In addition, we performed an unstratified...
Our objective was a retrospective study reporting on ovarian cancer screening in high-risk female population using both CA-125 and ultrasound over 7-year period. We used risk estimates of carrying BRCA mutation that were based family history. Subjects screened with every 6 months. Each 311 subjects had between 1 17 visits. Overall, 33 1209 (2.7%) results abnormal (>35 U/ml); 226 1342 (17%) ultrasounds abnormal, abnormalities ranging from benign appearing cystic changes to more ominous...
Tamoxifen is a selective estrogen receptor modulator that used to treat and prevent breast cancer; however, its use associated with an increased risk of endometrial cancer. metabolized by various cytochrome P450 (CYP) enzymes, but predominantly CYP3A4. In this study, we examined whether genetic variant the CYP3A4 gene, CYP3A4*1B, influences cancer risk--alone when tamoxifen exposure. We conducted case-control study on 566 cases 964 ethnically matched controls. The allele was present in 6%...