Fahd Al‐Mulla
A5045720408- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- BRCA gene mutations in cancer
- Immune cells in cancer
- Immune Response and Inflammation
- Genetic factors in colorectal cancer
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Rare Diseases
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
Dasman Diabetes Institute
2017-2025
Kuwait University
2014-2024
Qatif Central Hospital
2024
Ministry of Health
2023-2024
Diabetes Foundation
2023
Kuwait Petroleum Corporation (Kuwait)
2021
Kuwait Foundation for the Advancement of Sciences
2020
Genomics (United Kingdom)
2018
Maastricht University
2018
Clovis Oncology (United Kingdom)
2018
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients colorectal cancer were invited to provide that data in a schematized format for inclusion collaborative database called RASCAL (The in-colorectal-cancer group). Our results from 2721 such have been presented previously first time any common cancer, showed conclusively different gene mutations impacts on outcome, even when occur at same site genome. To explore effect Ki-ras stages...
Highlights•871 predisposition variants/CNVs discovered in 8% of 10,389 cases 33 cancers•Pan-cancer approach identified shared variants and genes across cancers•33 affecting activating domains oncogenes showed high expression•47 VUSs prioritized using cancer enrichment, LOH, expression other evidenceSummaryWe conducted the largest investigation to date, discovering 853 pathogenic or likely from types. Twenty-one single cross-cancer associations, including novel associations SDHA melanoma...
Epigenetic modifications such as histone methylation play an important role in human cancer metastasis. Enhancer of zeste homolog 2 (EZH2), which encodes the methyltransferase component polycomb repressive complex (PRC2), is overexpressed widely breast and prostate cancers epigenetically silences tumor suppressor genes. Expression levels novel metastasis Raf-1 kinase inhibitor protein (RKIP) have been shown to correlate negatively with those EZH2 cell lines well clinical tissues. Here, we...
The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared others. Nevertheless, it is also plausible that SARS-CoV-2 mutations giving rise different phylogenetic clades are responsible for apparent death rate disparities around world. Current research literature linking genetic make-up with fatalities lacking. Here, we suggest this...
Efficient sleep duration and its quality are increasingly recognized as important contributors for maintaining normal body weight. However, lifestyle social structure within the Arab-gulf region differ compared to those in western world. This study was specifically conducted Kuwait's population investigate link between (SQ) obesity absence of apnea (SA) onset.SQ measured by Pittsburgh Sleep Quality Index (PQSI) 984 participants, then verified 60 individuals including 20 lean (Body mass...
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk children, which is much lower than adults, remains unexplained. In an international cohort 112 children (<16 yr old) hospitalized for pneumonia, we report 12 (10.7%) aged 1.5–13 with (7 children), severe (3), and moderate (2) 4 the 15 known clinically recessive biochemically complete IFN immunity: X-linked TLR7 deficiency children) autosomal...
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies IFN-α2 alone (five patients) or with IFN-ω (eight from a cohort of 279 (4.7%) aged 6–73 yr influenza pneumonia. Nine four had antibodies high low concentrations, respectively, IFN-α2, six two IFN-ω. The patients’ increased A virus replication in both A549 cells reconstituted human airway epithelia. prevalence...
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize I interferons (IFNs)1,2, conferring a predisposition to life-threatening COVID-19 pneumonia3. Here we report patients NIK or RELB deficiency, specific of autosomal-dominant NF-κB2 also have neutralizing against IFNs and are at higher risk getting pneumonia. In these found only in individuals who heterozygous for variants associated both...
Obesity has become a global epidemic in the modern world, significantly impacting healthcare economy. Lifestyle interventions remain primary approach to managing obesity, with medical therapy considered secondary option, often used conjunction lifestyle modifications. In recent years, there been proliferation of newer therapeutic agents, revolutionizing treatment landscape for obesity. Notably, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide, liraglutide, and...
The mammalian target of rapamycin (mTOR) is a pivotal regulator, integrating diverse environmental signals to control fundamental cellular functions, such as protein synthesis, cell growth, survival, and apoptosis. Embedded in complex network signaling pathways, mTOR dysregulation implicated the onset progression range human diseases, including metabolic disorders diabetes cardiovascular well various cancers. also has notable role aging. Given its extensive biological impact, prime...
Abstract Purpose: Raf-1 kinase inhibitor protein (RKIP) was originally identified as the first physiologic of Raf/mitogen-activated kinase/extracellular signal-regulated (ERK) pathway. This pathway regulates fundamental cellular functions, including those that are subverted in cancer cells, such proliferation, transformation, survival, and metastasis. Recently, RKIP has been recognized a strong candidate for metastasis suppressor gene cell animal model systems. Therefore, we investigated...
Raf kinase inhibitor protein (RKIP) inhibits the and nuclear factor kappa B signaling pathways, suppresses metastasis in animal models. We examined whether RKIP expression primary colorectal cancers (CRCs) correlates with risk of overall survival.RKIP was immunohistochemically three separate cohorts: a tissue microarray containing 276 samples from human tumors normal tissues, retrospective studies 268 CRC patients 65 early-stage CRCs. Overall metastasis-free survival rates were measured.RKIP...
We propose the hypothesis that loss of estrogen receptor function which leads to endocrine resistance in breast cancer, also results trans-differentiation from an epithelial a mesenchymal phenotype is responsible for increased aggressiveness and metastatic propensity. siRNA mediated silencing MCF7 cancer cells resulted estrogen/tamoxifen resistant (pII) with altered morphology, motility rearrangement switch keratin/actin vimentin based cytoskeleton, ability invade simulated components...