A5028611475- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- HIV-related health complications and treatments
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- interferon and immune responses
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- COVID-19 and healthcare impacts
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Syphilis Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Tuberculosis Research and Epidemiology
- Dermatological and COVID-19 studies
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Animal Virus Infections Studies
- Reproductive tract infections research
- Parvovirus B19 Infection Studies
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2018-2023
Sağlık Bilimleri Üniversitesi
2019-2022
Rockefeller University
2022
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2020
İstanbul Eğitim ve Araştırma Hastanesi
2019-2020
Becton Dickinson (United States)
2019
Bezmiâlem Vakıf Üniversitesi
2017
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I III IFNs, except IFN-β. Having discovered four new patients, we describe the genetic, immunological, clinical features of seven IRF7-deficient from six families five ancestries. Five were homozygous two compound heterozygous for variants. Patients typically had one...
The novel coronavirus disease (COVID-19) pandemic has had a profound global impact economically, socially, and in many other areas. As vaccines are developed introduced, their effect on the both, individual scale is subject of intense curiosity. This study aimed to evaluate relationship between risk factors for hospitalization, severity, vaccination status COVID-19 inpatients hospital.Patients hospitalized June September 2021 were retrospectively analyzed three groups: unvaccinated,...
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a decreased number of platelets and mucocutaneous bleeding. Many viruses have been identified as triggers the process, including human immunodeficiency virus (HIV), hepatitis C (HCV), Epstein-Barr (EBV), cytomegalovirus (CMV), parvovirus, rubella, measles. Association with new severe acute respiratory syndrome coronavirus, SARS-CoV-2 infection (Covid-19 infection) has rarely reported. Here, we report oldest case ITP...
Amaç: HIV/AIDS hastalarında toksoplazmoz sık görülebilen fırsatçı infeksiyonlardandır ve yaşamı tehdit eden ensefalit, pnömoni gibi tablolara neden olabilir.Yöntemler: Anti-HIV pozitifliği ile Ocak 2006-Ağustos 2017 yılları arasında polikliniğimize başvuran, Western Blot testi HIV enfeksiyonu doğrulanan hastalar çalışma kapsamına alınmıştır.Hastaların demografik verileri, CD4+ T lenfosit sayıları, T. gondii IgG IgM değerleri retrospektif olarak hasta dosyalarından elde edilmiştir
Introduction: Syphilis co-infection is common in patients living with human immunodeficiency virus (HIV)/AIDS due to the route of transmission.In Turkey, both syphilis and HIV seroprevalences have been increasing recent years.In our study, it was aimed evaluate risk factors related HIV/AIDS who were followed up outpatient clinic.Materials Methods: Newly diagnosed 1057 clinic between January 2015 June 2019 included study.Demographic features patients, physical examination findings, CD4+ T...
In COVID-19 patients, the determination of relationship between elevated D-dimer level and prognosis thrombosis formation in early stages disease are very important. The aim this study was to investigate prognostic role levels based on presentation patients hospitalized with diagnosis COVID-19.The conducted laboratory-confirmed March 11 April 20, 2020. Patients diseases that could have caused an increase were excluded from study.The evaluation made across a total 1,669 comprising 782 (46.9...
We aimed to compare vaccinated and unvaccinated patients hospitalized with COVID-19 in terms of disease severity, need for intensive care unit (ICU) admission, death. In addition, we determined the factors affecting severity patients. Patients aged 18-65 years who were between September December 2021 retrospectively analyzed three groups: unvaccinated, partially vaccinated, fully vaccinated.A total 854 included. Mean age was 47.9 ± 10.6 years, 474 (55.5%) male. Of these, 230 (26.9%) 97...
Introduction: We aimed to evaluate the prevalence and clinical outcomes of COVID-19 in healthcare workers (HCWs) pre-vaccination post-vaccination periods. In addition, we determined factors associated with development after vaccination. Methodology: this analytical cross-sectional epidemiological study, HCWs who were vaccinated between January 14, 2021, March 21, included. followed up for 105 days 2 doses CoronaVac. Pre-vaccination periods compared. Results: A total 1,000 included, 576...
Altmış Bir Ekstrapulmoner Örnekte Anti-tüberküloz İlaç Duyarlılık Sonuçlarının MGIT Yöntemi İle Araştırılması Investigation of Anti-tuberculous Drug Sensitivity Results in Sixty-one Extrapulmonary Samples Using the Method Öz Amaç: Bu çalışmanın amacı, akciğer-dışı tüberküloz (TB) örneklerinde üremiş olan Mycobacterium tuberculosis kompleks (MTBC) izolatlarının majör TB ilaçları izoniazid (INH), rifampin (RIF), streptomisin (SM) ve etambutole (EMB) duyarlılıklarını ''Mikobakteri Üreme...
Group A beta-haemolytic streptococci (GAS), which are responsible for most cases of acute bacterial tonsillopharyngitis, transmitted from person to and may rarely cause foodborne outbreaks. This study aims report the epidemic caused by GAS in our hospital draw attention explosive outbreaks bacteria.Acute tonsillopharyngitis was seen 201 450 employees who ate cafeteria on 4-5 June 2015.GAS detected 106 (68%) 157 40 (63.5%) 62 throat culture samples. The attack rate 44.7%. suspected source...
Amaç: Çalışmamızda
Objective: Tuberculous meningitis (TBM) is the most severe form of extra pulmonary tuberculosis.Bacteriological confirmative tests based on mycobacterial cultures or polymerase chain reaction are time-consuming process may not help diagnose every TBM patient.Therefore, practical and easily applicable scoring systems be helpful in early diagnosis should applied clinical follow-up process.Methods: The features 20 patients with were retrospectively evaluated according to Thwaites' diagnostic...
Objective: It is difficult to distinguish cytomegalovirus (CMV) infection and disease since CMV a latent virus can cause recurrent infections. Positive tests may not necessarily be indicative of active disease. There no clear threshold value for plasma CMV-DNA polymerase chain reaction (PCR) levels from viral reactivation. In this study, we aimed determine numerical identify CMV-related clinical syndromes differentiate between in HIV/AIDS patients.
We aimed to determine the risk factors for hospitalization in treatment-naïve people living with HIV (PLHIV) and also frequency of HIV-related comorbidities hospitalized patients. Sociodemographic, clinical, laboratory findings PLHIV followed up our department between January 2015 July 2018 were retrospectively evaluated at initial presentation analyzed. A total 629 patients included. In all, 558 (88.7%) male 326 (51.8%) men who have sex (MSM), 8.6% all presentation. When comparing...
Amaç: Hepatit A virusu (HAV) infeksiyonu genellikle kontamine yiyecek veya su alımıyla fekal oral yoldan bulaşır.Ancak erkeklerle seks yapan erkek (men who have sex with men; MSM) popülasyonu arasında oral-anal seksle de geçiş ve salgınlar söz konusudur.Çalışmamızda takibimiz altında olan "human immunodeficiency virus" (HIV) ile infekte bireyler HAV seroprevalansı ilişkili risk faktörlerinin irdelenmesi amaçlamıştır.Yöntemler: İnfeksiyon Hastalıkları Polikliniği'nde Ocak 2015-Temmuz 2019...
Long life expectancy in people living with human immunodeficiency virus (PLWH) caused an increase comorbidities and co-medications. We aimed to analyse comedications drug-drug interactions (DDIs) antiretroviral therapy (ART)-naive PLWH the era of integrase inhibitors.A retrospective observational study was conducted between January 2016-August 2019. Patients' characteristics chronic co-medications were recorded. The University Liverpool HIV drug interaction database used for DDIs.Among 745...
Background: Syphilis is a global health issue, which continues to occur at high rates worldwide, particularly in HIV-infected men, who have sex with men (MSM). Hepatitis can present as an uncommon manifestation of syphilis, and the diagnosis may be overlooked favor more common causes liver injury this group. Objectives: This study aimed determine prevalence risk factors syphilitic hepatitis among individuals diagnosed acute syphilis. Methods: cross-sectional was conducted on regularly...
Objective: Taking precations to prevent contamination and developing prevention programs play a key role in the outbreak.For this purpose, use of personal protective equipment (PPE) healthcare workers (HCWs) their compliance with hand hygiene were investigated current Coronavirus disease-19 (COVID-19) outbreak. Methods:In study, 117 HCW, who diagnosed COVID-19 between 11 March 18 May 2020, did not meet case definition, 234 HCW included A survey consisting 28 questions was applied obtain...
Objectives: This study was undertaken to assess the prevalence of HBV/HCV co-infection demographic characteristics HIV/HBV and HIV/HCV co-infected patients its risk factors in a group HIV infected followed-up an infectious diseases clinical microbiology clinic. Methods: Treatment-naïve attending clinic between January 2015 June 2018 were included. Sociodemographic participants, infection factors, laboratory findings retrospectively evaluated using medical records. Results: Out 717 patients,...
Objective: Human Immundeficiency virus (HIV) infection is a risk factor for low bone mineral density (BMD).International HIV/AIDS guidelines do not recommend BMD screening every patient.In this study, we aimed to compare the factors development of osteoporosis/osteopenia between patients with treatment naive HIV infection, whom routine recommended and like men over 50 years age, postmenopausal women recommended.Materials Methods: A database was created in which demographic, clinical...
Background/Aim: Candidemia is a common cause of bloodstream infections in critically ill patients, resulting high mortality and morbidity. This retrospective case-control study was designed to identify epidemiological characteristics risk factors for candidemia an intensive care unit. Methods: A total 166 patients hospitalized the unit between January 2013 December 2017 were included this study. defined as at least one positive blood culture Candida spp. with fever or other clinical findings...
Objective: Klebsiella pneumoniae infections have been a problem in intensive care units (ICU) recent years due to multi-drug resistance. In this study, it was aimed analyze K. ICU, determine distribution of carbapenem resistance rates and risk factors. Methods: Nosocomial (NI) with between January 2017-January 2020 were evaluated retrospectively. cases recurrent infection, only the first episode included. Results: developed total 78 patients. Bloodstream (BSI) most common (51.3%), followed...