Kristina Mironska
A5052167424- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Respiratory viral infections research
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- interferon and immune responses
- Global Maternal and Child Health
- Streptococcal Infections and Treatments
- Cystic Fibrosis Research Advances
- Parvovirus B19 Infection Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune responses and vaccinations
- Kawasaki Disease and Coronary Complications
- Growth Hormone and Insulin-like Growth Factors
- Child Nutrition and Water Access
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Obesity, Physical Activity, Diet
- Viral Infections and Outbreaks Research
- Tuberculosis Research and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
Saints Cyril and Methodius University of Skopje
2018-2022
Rockefeller University
2022
PHI University Psychiatric Clinic - Skopje
2022
Boston Children's Hospital
2009
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk children, which is much lower than adults, remains unexplained. In an international cohort 112 children (<16 yr old) hospitalized for pneumonia, we report 12 (10.7%) aged 1.5–13 with (7 children), severe (3), and moderate (2) 4 the 15 known clinically recessive biochemically complete IFN immunity: X-linked TLR7 deficiency children) autosomal...
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies IFN-α2 alone (five patients) or with IFN-ω (eight from a cohort of 279 (4.7%) aged 6–73 yr influenza pneumonia. Nine four had antibodies high low concentrations, respectively, IFN-α2, six two IFN-ω. The patients’ increased A virus replication in both A549 cells reconstituted human airway epithelia. prevalence...
Autosomal recessive IRF7 deficiency was previously reported in three patients with single critical influenza or COVID-19 pneumonia episodes. The patients' fibroblasts and plasmacytoid dendritic cells produced no detectable type I III IFNs, except IFN-β. Having discovered four new patients, we describe the genetic, immunological, clinical features of seven IRF7-deficient from six families five ancestries. Five were homozygous two compound heterozygous for variants. Patients typically had one...
BACKGROUND: In the past several decades, increasing frequency of overweight and obese children adolescents in world has become a public health problem. It contributed significantly to already high tide diabetes, cardiovascular cerebrovascular diseases.AIM: To investigate insulin resistance evaluate metabolic profile resistant non-insulin adolescents.SUBJECTS AND METHODS: The study included 96 (45 boys, 51 girls) aged 4-17 years old (10.50 ± 2.87 years). Only participants with Body Mass Index...
BACKGROUND: Adverse reactions to intravenous immunoglobulins (IVIG) are divided by organ system involved, or timing of onset–immediate which occur during infusion usually rate-related, true IgE-mediated anaphylaxis and delayed reaction hours days after the infusion.
 AIM: To describe adverse events patients given IVIG infusions.
 METHODS: Total number receiving was 41 with 25 males (60.97%) 16 females (39.02%), age 2 months-35 years. A total infusions 1350.
 RESULTS: 15, 14...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
BACKGROUND: Small for gestational age (SGA)-born children are a heterogeneous group with few genetic causes reported. Genetic alterations in the IGF1 receptor (IGF1R) found some SGA children.
 AIM: To investigate whether IGF1R gene present born PATIENTS AND METHODS: We analysed 64 who stayed short (mean -3.25 ± 0.9 SDS) within first 4 years of age, and 36 caught up growth (0.20 1.1 SDS). PCR products all coding exons were screened by dHPLC followed direct sequencing conspicuous...
Abstract Multisystem Inflammatory Syndrome in Children (MIS-C) is characterized by an inflammation with fever, elevated inflammatory markers, conjunctivitis, rash, impaired coagulation, gastrointestinal symptoms and cardiac abnormalities that may progress to multiorgan failure. The presence of a positive COVID-19 antigen via PCR test, serological testing for antibodies or close contact person diagnosed helps differentiate MIS-C from other diseases. Gastrointestinal are recognized be...
Patients with X-linked agammaglobulinemia (XLA) are prone to recurrent bacterial infections due low levels of immunoglobulins.Clinical symptoms include otitis media, bronchitis, pneumonia, meningitis, skin infection and arthritis.In the majority cases arthritis can be shown caused by infection, but also aseptic autoimmune diseases may present.Monoarthritis oligoarthritis is usual pattern, although polyarthritis occur.We present diagnostic therapeutic problems in two arthritis.
Cryopyrin-associated periodic syndromes (CAPSs) are a growing family of autoinflammatory diseases, also known as fever syndromes. There three forms CAPS: (1) Familial Cold syndrome or familial cold urticaria, (2) Muckle-wells syndrome, and (3) neonatal-onset multisystem inflammatory disease chronic infantile neurological cutaneous articular syndrome. Genetic mutations in the NLRP3 gene were found to be present most patients. The foremost common findings between all CAPS disorders rash, which...
BACKGROUND: Small for gestational age children (SGA) is born on term with BW and or BL of -2.0 standard deviation score (SDS). SGA have an increased risk being short, developing DM, cardiovascular cerebrovascular disease. Often defects IGF1R are the cause SGA. Most frequently affected part gene exon 2.AIM: To investigate whether 2 in children.PATIENTS AND METHODS: A cohort 100 was evaluated alterations IG1R gene. Their anthropometric parameters, IGF1 serum concentrations SDS values were...
Abstract Neutrophil functional disorders thought to be uncommon, yet important as a cause of morbidity and mortality in infants children. During the first years life, when immune system is still not completely mature, viral infections are frequent antibiotic overuse can damage alter response, inadequate nutrition followed with iron deficient anemia malnutrition lead child`s organism state immunodeficiency. Sometimes difficult distinguish at beginning weather patient suffering from existing...
Abstract Malnutrition in childhood continues to be one of the most important risk factor for secondary immunodeficiency world; therefore should think existence malnutrition a child suffering frequent infections, not only developing country, rarely but still possible developed country also. Undernourishment early is trigger starting vicious cycle impaired immunity, recurrent and worsening malnutrition. Taking out from that an urgent complex process, which parallel infection controlled...