A5112195323- Immunodeficiency and Autoimmune Disorders
- Cystic Fibrosis Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Blood disorders and treatments
- Pediatric health and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Diabetes and associated disorders
- Genomics and Rare Diseases
- Immune responses and vaccinations
- Parvovirus B19 Infection Studies
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Pharmaceutical studies and practices
- T-cell and B-cell Immunology
- Neurogenetic and Muscular Disorders Research
- Mycobacterium research and diagnosis
- Congenital Ear and Nasal Anomalies
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Antifungal resistance and susceptibility
- Ethics and Legal Issues in Pediatric Healthcare
- Chronic Disease Management Strategies
- Adolescent and Pediatric Healthcare
Jeffrey Modell Foundation
2013-2024
New York Hospital Queens
2022
NewYork–Presbyterian Hospital
2022
Primary immunodeficiencies (PI), which include more than 450 single-gene inborn errors of immunity and may affect up to 1% the population, are genetic disorders that impair immune system. If not properly identified treated, individuals with PI subject serious, prolonged, sometimes life-threatening infections or autoimmunity. Despite advancements, awareness remains a critical issue for physicians public alike, as this leads enhanced expedited management these conditions. To address issue,...
Immunodeficiency-associated vaccine-derived polioviruses (iVDPVs) have been isolated from primary immunodeficiency (PID) patients exposed to oral poliovirus vaccine (OPV). Patients may excrete strains for months or years; the excreted viruses are frequently highly divergent parental OPV and shown be as neurovirulent wild virus. Thus, these represent a potential reservoir transmission of in post-eradication era. In support WHO recommendations better estimate prevalence excreters among PIDs...
Background: Early diagnosis of primary immunodeficiency disease leads to reductions in illness and decreased healthcare costs. Analysis electronic health record data may allow for identification persons at risk host-defense impairments from within the general population. Our hypothesis was that coded infection history would inform individual ultimately lead diagnosis. Methods: In this study we assessed by analyzing diagnostic codes pharmacy records members (n = 185,892) a large pediatric...
Genetic disorders that impair the immune system, known as Primary Immunodeficiencies (PI), include over 450 single-gene inborn errors of immunity. Timely and appropriate diagnosis treatment is vital to quality life (QOL) sometimes survival, patients are susceptible frequent, persistent, severe, life-threatening infections or autoimmunity. Suspected PI do not have a genetic often endure prolonged, onerous, inefficient, expensive experience, diagnostic odyssey. The resulting delay prohibits...
Abstract Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic and often life-threatening infections and/or autoimmunity if not diagnosed treated. Patients with a suspected PI, but without diagnosis, commonly undergo diagnostic odyssey is costly, time-consuming, arduous. This delay diagnosis prevents appropriate disease management treatment, contributing to prolonged suffering decreased quality life. Although next generation sequencing (NGS) can...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
Jeffrey Modell Foundation centers' network activities in Central and Eastern Europe (JMF CEE) have contributed to the development of care for patients with primary immunodeficiencies. On data continuously collected from individual centers participating countries since 2011, we demonstrate a steady improvement number aspects concerning complex The presented show an awareness about these rare diseases across whole European region, increase newly diagnosed as well genetically confirmed cases,...