A5067435005- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Gastrointestinal motility and disorders
- Stoma care and complications
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Ion Channels and Receptors
- Ear and Head Tumors
- Microscopic Colitis
- Urinary Bladder and Prostate Research
- Hernia repair and management
- Gastrointestinal disorders and treatments
- Caveolin-1 and cellular processes
- Inflammatory Bowel Disease
- Pelvic floor disorders treatments
- Whipple's Disease and Interleukins
- Nutrition and Health in Aging
- Gastrointestinal Tumor Research and Treatment
- Kidney Stones and Urolithiasis Treatments
- Urological Disorders and Treatments
Brown University
2008-2020
SouthCoast Health
2014-2020
Charlton Memorial Hospital
2018-2020
Warren Alpert Foundation
2019
Bedford Research Foundation
2014
Rhode Island Hospital
2000-2014
Providence College
1987-2014
American Society of Clinical Oncology
2014
Colon and Rectal Surgery Associates
2010
University Surgical Associates
2006
Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients colorectal cancer were invited to provide that data in a schematized format for inclusion collaborative database called RASCAL (The in-colorectal-cancer group). Our results from 2721 such have been presented previously first time any common cancer, showed conclusively different gene mutations impacts on outcome, even when occur at same site genome. To explore effect Ki-ras stages...
Abstract Purpose: Through the use of molecular markers, it may be possible to identify aggressive tumor phenotypes and tailor therapies treat them. This approach would particularly useful for stage II colon cancer. The purpose this study was define prognostic value epidermal growth factor receptor (EGFR), c-MET, β-catenin, p53 protein expression in TNM cancer using tissue microarray technology. Experimental Design: In study, we retrospectively analyzed, resected, otherwise untreated...
Objective To assess the utility of gracilis muscle transposition in treatment iatrogenic rectourethral fistula. Summary Background Data Iatrogenic fistula poses a rare but challenging complication for prostate cancer. A variety procedures have been described to treat this condition, none which has gained acceptance as procedure choice. The aim study was review authors' experience with Methods retrospective chart all patients who underwent performed, and follow-up established by telephone...
Following preoperative chemoradiation and surgery, many patients with stage II to III rectal cancer are unable tolerate full-dose adjuvant chemotherapy. BrUOG R-224 was designed assess the impact of COmplete Neoadjuvant Treatment for REctal (CONTRE), primary chemotherapy followed by on treatment delivery, toxicities, pathologic response at surgery. Patients clinical (T3 T4 and/or N1 N2) received 8 cycles modified FOLFOX6 capecitabine 825 mg/m bid concurrent 50.4 Gy intensity-modulated...
Objectives: National Comprehensive Cancer Network (NCCN) guidelines for stage III colon cancer define low-risk versus high-risk patients based on T (1 to 3 vs. 4) and N 2) status, with some variations in treatment. This study analyzes the impact of tumor deposits (TDs), poor differentiation (PD), perineural invasion (PNI), lymphovascular (LVI) survival. Materials Methods: A retrospective analysis (2010-2015) Database treated both surgery chemotherapy was conducted. Data extracted sex, race,...
Interleukin 1 beta (IL-1 beta) levels are elevated in the colonic mucosa of patients with ulcerative colitis (UC). We propose that IL-1 may also be circular muscle layer colon and partially responsible for motility dysfunction observed UC. Cohort analytic study. Research laboratory a tertiary academic medical center. Normal smooth was obtained from disease-free margins human sigmoid specimens resected cancer compared An enzyme-linked immunosorbent assay used to measure IL-l beta. Standard...
To evaluate the impact of p53 gene mutations on long-term survival in patients with intermediate stage carcinoma colon.Retrospective cohort study; median follow-up 87 months.Tertiary care academic medical center.Mutational analysis was conducted a single institution 141 consecutive resected II (n = 71) and III 70) colon carcinoma. Archival pathology specimens were analyzed for point exons from by means amplification direct sequencing polymerase chain reaction.The adverse histopathologic...
Ulcerative colitis (UC) affects colonic motor function, but the mechanism responsible for this dysfunction is not well understood. We have shown that neurokinin A (NKA) may be an endogenous neurotransmitter mediating contraction of human sigmoid circular muscle (HSCCM). To elucidate factors UC dysfunction, we examined role hydrogen peroxide (H(2)O(2)) in decrease NKA-induced response HSCCM. As previously demonstrated, or Ca(2+) increase normal cells mediated by release from intracellular...
Necrotizing fasciitis is a rapid, potentially fatal soft tissue infection. Chickenpox common childhood illness not usually associated with severe complications. We present the case of an 8-year-old girl necrotizing upper back arising from superinfection varicella skin lesions. may have devastating sequelae, including septic shock, which mandate vigorous fluid resuscitation, appropriate antimicrobial therapy, and early aggressive surgical debridement.
Diminished venous return is the primary determinant of reduced cardiac output in hemorrhagic hypoperfusion. In this study hemodynamic response two therapies commonly employed to increase hypoperfusion—pneumatic antishock garment (PASG) application and Trendelenburg (TREND) positioning—were compared normovolemic man. Five patients had PASG pressure 20 mm Hg with 10° Trendelenburg, eight 40 Trendelenburg. at both resulted a significant CVP (11.1 ± 1.9 baseline 16.0 2.7 40; p < 0.01) left...