A5058180908- Inflammatory Bowel Disease
- Clinical Nutrition and Gastroenterology
- Microscopic Colitis
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Burn Injury Management and Outcomes
- Stoma care and complications
- Nutrition and Health in Aging
- Gastroesophageal reflux and treatments
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Dysphagia Assessment and Management
- Gastrointestinal Tumor Research and Treatment
- Intestinal and Peritoneal Adhesions
- Enhanced Recovery After Surgery
- Sepsis Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders
- Minimally Invasive Surgical Techniques
- Pelvic floor disorders treatments
- Hernia repair and management
University of North Carolina at Chapel Hill
2005-2021
Denver Health Medical Center
1994
University of Colorado Denver
1994
Meyer (China)
1991
Rutgers, The State University of New Jersey
1989
University of Pennsylvania
1986-1989
Philadelphia University
1988
Hospital of the University of Pennsylvania
1986
In this multicenter prospective controlled trial, 98 evaluable patients sustaining major torso trauma were randomized to receive early enteral nutrition with a new "immune-enhancing" diet (study: n = 51) or standard stress formula (control: 47). At baseline, both groups had comparable demographics and injury Severity Scores. After 7 days of feeding, the equivalent increases in serum total protein, albumin, transferrin concentrations. Patients receiving diet, however, experienced...
Objective The clinical presentation and course of Crohn's disease (CD) is highly variable. We sought to better understand the cellular molecular mechanisms that guide this heterogeneity, characterise processes associated with phenotypes. Design examined both gene expression regulation (chromatin accessibility) in non-inflamed colon tissue from a cohort adult patients CD control patients. To support generality our findings, we analysed previously published data large treatment-naïve...
The effect of a pectin-supplemented elemental diet on intestinal adaptation to massive small bowel resection in the rat was investigated this study. Sixty adult Sprague-Dawley rats underwent placement feeding gastrostomy and swivel apparatus. Control animals (N = 16) were then returned their cages while remaining an 80% anastomosis (resected, N 44). Postoperatively, randomly assigned receive either fat- fiber-free (no pectin) or same supplemented with 2% pectin (pectin). After 8 days full...
OBJECTIVES: The ileal pouch anal anastomosis is a safe and effective procedure but also associated with pouchitis, small bowel obstruction, incontinence. We prospectively evaluated the health-related quality of life using generic disease-specific measures in cohort patients ulcerative colitis undergoing anastomosis. METHODS: Health-related included Time Trade-off, Rating Form IBD Patient Concerns, Short-Form 36. Assessments occurred preoperatively 1, 6, 12 months postoperatively. RESULTS:...
INTRODUCTION: Postoperative abdominal adhesions are associated with significant morbidity and mortality, placing a substantial burden on healthcare systems worldwide. Development of bioresorbable membrane containing up to 23 percent glycerol chemically modified sodium hyaluronate/carboxymethylcellulose offers ease handling has been shown provide postoperative adhesion prevention in animals. This study was designed assess the safety evaluate its efficacy reducing incidence, extent, severity...
Diarrhea is one of the most common complications in patients who receive tube‐feeding formulas. Since colon final site water and electrolyte absorption ultimately determines fecal composition, diarrhea during tube feeding may result from altered colonic function. The lack dietary fiber, such as pectin, formulas be means by which function affected. purpose this study was to determine effect a standard, liquid, commercially available, isotonic formula (ITFF) effects supplementing ITFF with...
Alterations in intestinal permeability and immune function were investigated a murine femur fracture (FFx) model. We postulated that soft tissue injury associated with closed FFx (crush injury) would result greater immunosuppression open (surgical division). AKR mice randomized to four groups (Normal, Sham, Open FFx, Closed FFx) studied at 24 96 h post-injury. Immune was assessed by splenocyte blastogenic response class-specific immunoglobulin production. Intestinal measurement of whole...
Objective Chronic ethanol (EtOH) intake and injury are both associated with increased susceptibility to infection in the host. This study examined immune gastrointestinal alterations induced by chronic EtOH injury, compared effects of enteral intravenous administration EtOH. Design Rats received 20% daily for 14 days gavage [oral (PO)] or superior vena cava [intravenous (IV)] infusion. Mean blood concentrations at 90 minutes after were 95.3 mg/dL (PO) 94.4 (IV). An additional group animals...
Intestinal macrophages (IMs) are uniquely programmed to tolerate exposure bacteria without mounting potent inflammatory responses. The cytokine IL-10 maintains the macrophage anti-inflammatory response such that loss of results in chronic intestinal inflammation. To investigate how IL-10-deficiency alters IM programming and bacterial tolerance, we studied changes chromatin accessibility from two distinct niches, intestine bone-marrow, both wild-type IL-10-deficient (Il10(-/-) ) mice. We...
Crohn's disease (CD) is highly heterogeneous, due in large part to variability cellular processes that underlie the natural history of CD, thereby confounding effective therapy. There a critical need advance understanding mechanisms drive CD heterogeneity.We performed small RNA sequencing adult colon tissue from and NIBD controls. Colonic epithelial cells immune were isolated colonic tissues, microRNA-31 (miR-31) expression was measured. miR-31 measured colonoid cultures generated controls...
Objective To assess the statistical association of Acute Physiology and Chronic Health Evaluation (APACHE II) score with multiple intervention outcome variables in surgical ICU patients. Design Continuous data collection on every patient admitted to for a 21-month period. Materials Methods For ICU, APACHE II scores were calculated relationship between as an independent predictor was assessed selected study. The tested included: treatment measures such days ventilator; arterial catheter,...