Cecilia B. Korol
A5053511865- Immunodeficiency and Autoimmune Disorders
- Hepatitis Viruses Studies and Epidemiology
- Immune responses and vaccinations
- Tuberculosis Research and Epidemiology
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Immune Cell Function and Interaction
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Blood disorders and treatments
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
Inserm
2019-2022
National Institutes of Health Clinical Center
2020
Institut des Maladies Génétiques Imagine
2019
Université Paris Cité
2019
Garrahan Hospital
2015
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Fulminant viral hepatitis (FVH) is a devastating and unexplained condition that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. We report child who died of FVH upon A virus (HAV) at age 11 yr was homozygous for private 40-nucleotide deletion in IL18BP, which encodes the IL-18 binding protein (IL-18BP). This mutation loss-of-function, unlike variants found state public databases. show human IL-18BP are both secreted mostly by hepatocytes...
Abstract Fulminant viral hepatitis (FVH) caused by A virus (HAV) is a life-threatening disease that typically strikes otherwise healthy individuals. The only known genetic etiology of FVH inherited IL-18BP deficiency, which unleashes IL-18-dependent lymphocyte cytotoxicity and IFN-γ production. We studied two siblings who died from combination early-onset inflammatory bowel (EOIBD) due to HAV. sibling tested was homozygous for the W100G variant IL10RB previously described in an unrelated...
Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The collected displayed distinct genomic phenotypic features consistent host adaptation associated changes antibiotic susceptibility virulence traits.Background: report case of partial recessive deficiency who developed disseminated infection after neonatal vaccination (BCG-vaccine). Distinct M. BCG-vaccine derived clinical strains were...