A5034410852- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune responses and vaccinations
- Tuberculosis Research and Epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Urinary Tract Infections Management
- Biosimilars and Bioanalytical Methods
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Cutaneous lymphoproliferative disorders research
- Cytokine Signaling Pathways and Interactions
- Antibiotic Resistance in Bacteria
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Cystic Fibrosis Research Advances
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Pharmaceutical studies and practices
- Pelvic floor disorders treatments
- Drug-Induced Adverse Reactions
- Urinary Bladder and Prostate Research
National Institutes of Health Clinical Center
2009-2020
United States Food and Drug Administration
2015-2016
University of California San Francisco Medical Center
2002
The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free (Mg(2+)) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels Epstein-Barr virus (EBV) and predisposition to lymphoma. We show that decreased Mg(2+) causes defective expression the natural killer activating receptor NKG2D (NK) CD8(+) T cells impairs cytolytic responses against EBV. Notably, supplementation MAGT1-deficient patients restores while concurrently reducing...
Uncomplicated urinary tract infections are among the most frequently occurring in United States, resulting an estimated 8 million office visits and 1 hospital admissions each year.1,2,3 Between 40% 50% of women have reported having at least one infection their lives.4 Urinary can be classified by anatomic site involvement into lower upper infections. Infections include cystitis, urethritis, prostatitis, epididymitis, those pyelonephritis. Urinary may further as complicated or...
Despite the known significant drug-drug interaction between isavuconazole and tacrolimus, there are no recommendations on dose adjustment when these drugs given concomitantly. We report a patient with mediastinal Aspergillus fumigatus infection resistant to posaconazole describe how she was successfully managed tacrolimus therapeutic drug-level monitoring.Our presented mediastial infection, 2 years after lung transplantation. A. posaconazole, had intolerance voriconazole shown by elevated...
What is known and objective Posaconazole an extended-spectrum triazole antifungal with activity against a variety of clinically significant yeasts moulds. not currently approved by the U.S. Food Drug Administration for use in children younger than 13 years age. Our primary was to describe dosing observed trough concentrations posaconazole oral suspension paediatric patients at National Institutes Health Clinical Center (Bethesda, MD). Methods This retrospective single-centre study reviewed...
Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The collected displayed distinct genomic phenotypic features consistent host adaptation associated changes antibiotic susceptibility virulence traits.Background: report case of partial recessive deficiency who developed disseminated infection after neonatal vaccination (BCG-vaccine). Distinct M. BCG-vaccine derived clinical strains were...