A5083642298- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Soft tissue tumor case studies
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Digestive system and related health
- Immunodeficiency and Autoimmune Disorders
- Neurofibromatosis and Schwannoma Cases
- Neuroendocrine Tumor Research Advances
- Microscopic Colitis
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Soft tissue tumors and treatment
- Pediatric Hepatobiliary Diseases and Treatments
Southmead Hospital
2011-2025
North Bristol NHS Trust
2017-2023
University Hospitals Bristol NHS Foundation Trust
2011-2022
University of Bristol
1994-2021
American Museum of Natural History
2019
St. Michael's Hospital
2016
Bristol Royal Infirmary
2006-2015
Kowloon Hospital
2012
Centro Universitário Newton Paiva
2011
John Radcliffe Hospital
2003-2009
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues. Gastrointestinal stromal tumour (GIST) is the commonest STS and arises within wall of gastrointestinal (GI) tract. While most GISTs occur stomach they do all parts GI As with other STS, it important that managed by expert teams, to ensure consistent optimal treatment, as well recruitment clinical trials, ongoing accumulation further knowledge disease. The development appropriate guidance, an experienced panel...
Whether immunohistochemical markers increase accuracy in predicting prognosis for gastrointestinal stromal tumours (GISTs) remains uncertain. However, past studies have used only small, heterogeneous patient groups. Our aim was to test previously studied and more novel morphological features as well four prognostic indicators amongst a large cohort of surgically resected, gastric GISTs.Tissues from 127 mesenchymal were collected retrospectively subjected repeat histological assessment...
CDX1 is a transcription factor that plays key role in intestinal development and differentiation. However, the downstream targets of are less well defined than those its close homologue, CDX2. We report here identification using microarray gene-expression analysis other approaches. Keratin 20 (KRT20), member intermediate filament well-known marker differentiation, was initially identified as one genes likely to be directly regulated by CDX1. KRT20 mRNA expression were significantly...
Aims: To assess observer agreement in the diagnosis of colorectal serrated polyps, particular, adenomas and admixed polyps (i.e. ‘polyps with hyperplastic adenomatous glands’). Methods results: Sixty cases large bowel were assessed by four specialist gastrointestinal histopathologists allocated into one five categories: adenoma, polyp, conventional other serration. Complete amongst all assessors was seen only two‐fifths cases. The overall κ value for distinguishing between categories 0.49....
Analysis of colorectal carcinoma (CRC) tissue for KRAS codon 12 or 13 mutations to guide use anti-epidermal growth factor receptor (EGFR) therapy is now considered mandatory in the UK. The scope this practice has been recently extended because data indicating that NRAS and additional also predict poor response anti-EGFR therapy. following document provides guidance on RAS (i.e., ) testing CRC setting personalised medicine within UK particularly NHS. This covers issues related case selection,...
Aims : To assess whether Ki67 and p53 immunostaining may assist the diagnosis grading of ulcerative colitis‐related dysplasia. Methods results Location staining location intensity were assessed in colitis (UC) cases showing features high‐grade dysplasia (HGD, n = 14), low‐grade (LGD, 22), ‘indefinite for dysplasia’ ( 12), or regenerative atypia (RA, 22). Good intra‐ inter‐observer reproducibilities demonstrated performance these assessments. All showed extension above basal third crypt....
The molecular pathogenesis of Barrett's metaplasia (BM) the esophagus is poorly understood. change to an intestinal phenotype occurs on a background esophagitis due refluxing acid and bile. CDX1, important regulator normal development, was studied as potential key molecule in BM. CDX1 mRNA protein were universally expressed all samples BM tested but not esophageal squamous or gastric body epithelia. This tissue-specific expression attributable methylation status promoter. Conjugated bile...
Tumour deposits (TDs) are an important prognostic marker in colorectal cancer. However, the classification, and inclusion staging, of TDs has changed significantly each tumour-node-metastasis (TNM) edition since their initial description TNM-5, terminology remains controversial. Expert consensus is needed to guide future direction precision staging.A modified Delphi process was used. Statements were formulated sent participants as online survey. Participants asked rate agreement with...
Perianal abscess is common. Traditionally, postoperative perianal cavities are managed with internal wound packing, a practice not supported by evidence. The aim of this randomized clinical trial (RCT) was to assess if non-packing less painful and it associated adverse outcomes.The Postoperative Packing Abscess Cavities (PPAC2) multicentre, RCT (two-group parallel design) adult participants admitted an NHS hospital for incision drainage primary abscess. Participants were 1:1 (via online...
Aims ‘Vascular intrusion’ is a proposed but poorly recognised phenomenon of colorectal adenomas whereby dysplastic epithelium forced into blood vessels. This study aimed to validate its existence and characterise histological features that distinguish it from true vascular invasion. Methods results Three gastrointestinal pathologists independently assessed 38 polyps showing possible intrusion as two cohorts. After the cohort A (15 cases) assessment, met decide upon diagnostic criteria...
To determine the spectrum and outcome of colorectal diseases occurring in adult liver allograft recipients.A retrospective cohort analysis clinical, microbiological histopathological data regarding disease.Forty three out 302 primary recipients were transplanted followed up (at median 42 months) at a tertiary referral centre/teaching hospital.Out patients, 43 (14%) investigated (by endoscopy and/or laparotomy) for symptoms disease after orthotopic transplantation. The were: diarrhoea (n =...
Abstract Colorectal carcinoma shows several sex‐related differences with regard to incidence, response chemotherapy and microsatellite instability. These may relate differential expression of ERβ1 (wild‐type) as well the truncated ERβ2 ERβ5 splice variant isoforms, which have recently been detected in normal malignant colorectal epithelium. This hypothesis was tested through study ERβ isoform protein and/or mRNA amongst 91 primary cases 20 cell lines. Study latter showed an absolute...
Recent data suggest that the incidence of malignant appendiceal tumours is increasing. This study aimed to determine temporal trends in within England and a possible influence by demographic factors.All incident cases patients aged 20 years above were identified from National Cancer Registration Analysis Service database between 1995 2016 using ICD-9/10 codes. Cancers categorized according histology. Joinpoint regression analysis was used investigate changes age-standardized rates age, sex,...
Expression of the homeobox protein CDX1 is lost or reduced in a significant proportion colorectal carcinomas (CRCs) but underlying mechanism for this unclear. We have demonstrated absence mRNA expression 7 37 CRC cell lines and shown that all methylated promoter. Twenty-five showed both an unmethylated The five remaining had partially promoter expressed mRNA; when treated with demethylating agent, 5-aza-2'-deoxycytidine, these increased expression. No mutations were found coding regions...
Epstein-Barr virus (EBV) is associated with several lymphoid and epithelial human malignancies. The latter include gastric adenocarcinomas, while sporadic colorectal adenocarcinomas (CRCs) have been reported to be EBV-negative. Recently, increased numbers of EBV-infected B lymphocytes detected in intestinal mucosal samples affected by ulcerative colitis (UC) and, a lesser extent, Crohn's disease (CD). Both CRC non-Hodgkin's lymphoma (NHL) are recognized complications inflammatory bowel...
Schimke immunoosseous dysplasia (SIOD), which is characterized by prominent spondyloepiphyseal dysplasia, T-cell deficiency, and focal segmental glomerulosclerosis, a panethnic autosomal recessive multisystem disorder with variable expressivity. Biallelic mutations in switch/sucrose nonfermenting (swi/snf) &!ndash;related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) are the only identified cause SIOD. However, among 72 patients from different...
Introduction Surgery (oesophagectomy), with neoadjuvant chemo(radio)therapy, is the main curative treatment for patients oesophageal cancer. Several surgical approaches can be used to remove an tumour. The Ivor Lewis (two-phase procedure) usually in UK. This performed as open oesophagectomy (OO), a laparoscopically assisted (LAO) or totally minimally invasive (TMIO). All three are National Health Service, LAO and OO most common. However, there limited evidence about which approach best terms...
Introduction In the past 5 years, there have been several advances in management of inflammatory bowel disease (IBD). We aim for a new guideline to update most recent published 2019. present prospective operating procedure and technical summary protocol manuscript. Methods ‘Grading Recommendations Assessment, Development Evaluation’ (GRADE) will be followed development guideline, approach as laid out GRADE handbook, supported by WHO. The group is formed variety disciplines, across both...
A 58-year-old man presented with a 4-month history of rapidly enlarging asymptomatic tumour on the scalp vertex. Six years earlier, patient had undergone subtotal gastrectomy for presumed gastrointestinal stromal (GIST). The extended to peritoneal surfaces, and foci vascular invasion were also seen. No adjuvant treatment was given. Owing diagnostic difficulties tumour, comparison made previous gastric neoplasm. Both features consistent glomus which suggested revised diagnosis primary...
Wong N A C S & Shelley‐Fraser G (2010) Histopathology 57 , 250–258 Specificity of DOG1 (K9 clone) and protein kinase theta (clone 27) as immunohistochemical markers gastrointestinal stromal tumour Aims: (PKC) are both sensitive (GIST). However, there conflicting data regarding the specificity most commonly used PKC antibody 27), no existing only known commercially available at time writing. This study’s aim was to characterize immunoreactivity patterns monoclonal antibodies amongst a...