A5013117943- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Pelvic floor disorders treatments
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Pelvic and Acetabular Injuries
- Ovarian cancer diagnosis and treatment
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Enhanced Recovery After Surgery
- Hernia repair and management
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Anatomy and Medical Technology
- Patient Dignity and Privacy
- Medical Malpractice and Liability Issues
- Infant Nutrition and Health
Basingstoke and North Hampshire Hospital
2014-2024
Imperial College London
2018-2022
Hampshire Hospitals NHS Foundation Trust
2014-2022
Hammersmith Hospital
2022
Royal Marsden Hospital
2017-2021
Croydon University Hospital
2011-2021
Royal Marsden NHS Foundation Trust
2019-2021
Royal College of Surgeons of England
2021
Pelican Cancer Foundation
2020
St Andrew’s Hospital
2018
Summary Background Data: MRI assessment of rectal cancer not only assesses tumor depth and surgical resectability but also extramural disease which affects prognosis. We have observed that nonnodal nodules (tumor deposits; mrTDs) a distinct appearance compared to lymph node metastases (mrLNMs). Objective: aimed assess whether mrTDs mrLNMs different prognostic implications compare these other known markers. Methods: This was retrospective cohort study 233 patients undergoing resection for...
Selection of patients for preoperative treatment in rectal cancer is controversial. The new 2020 National Institute Health and Care Excellence (NICE) guidelines, consistent with the Comprehensive Cancer Network recommend radiotherapy all except those radiologically staged T1-T2, N0 tumours. We aimed to assess outcomes non-irradiated stratify results on basis NICE criteria, compared known MRI prognostic factors now omitted by NICE.For this retrospective cohort study, we identified undergoing...
Abstract Background MRI is crucial in staging patients with rectal cancer and planning treatment. The aim was to analyse the prognostic role of MRI-predicted tumour deposits and/or extramural vascular invasion (mrTD/EMVI) a cohort undergoing surgical resection, selective neoadjuvant chemoradiotherapy (nCRT). Method Retrospective analysis single-centre consecutive low anterior resection or abdominoperineal excision between 2008 2020. Unit policy nCRT for threatened involved circumferential...
Tumour deposits (TDs) are an important prognostic marker in colorectal cancer. However, the classification, and inclusion staging, of TDs has changed significantly each tumour-node-metastasis (TNM) edition since their initial description TNM-5, terminology remains controversial. Expert consensus is needed to guide future direction precision staging.A modified Delphi process was used. Statements were formulated sent participants as online survey. Participants asked rate agreement with...
Abstract Background Preoperative immunonutrition has been proposed to reduce the duration of hospital stay and infective complications following major elective surgery in patients with gastrointestinal malignancy. A multicentre 2 × factorial RCT was conducted determine impact preoperative postoperative versus standard nutrition oesophageal cancer. Methods Patients were randomized before oesophagectomy (IMPACT®) isocaloric/isonitrogenous nutrition, then further after operation nutrition....
Preoperative TNM stratification of colon cancer on computed tomography (CT) does not identify patients who are at high risk recurrence that could be selected for preoperative treatment.To evaluate the utility CT findings prognosis sigmoid cancer.This prognostic study used retrospective data from underwent bowel resection between January 1, 2006, and 2015, a tertiary care center receiving international national referrals colorectal cancer. Statistical analysis was performed in April 2019.Cox...
Introduction Tumour deposits (TDs) are a poor prognostic marker when seen on pathology, and worse than lymph node metastases (LNMs). They now being reported MRI as discontinuous nodules of extramural venous invasion but this diagnosis has not been validated it is unclear how correlates with the TDs pathology. Methods analysis This prospective interventional clinical trial which aims to directly map location correlate what pathology findings at each location. All patients rectal cancer...
There is a paucity of data on which to base estimates the energy requirements elderly. In general, ageing appears be associated with reduction in requirement arising from physical activity and loss fat-free mass. The aim present study was measure total expenditure (TEE), basal metabolic rate (BMR), expended (calculated as TEE–BMR) group healthy elderly women living community Southampton. Mean rates TEE (9.21 (SD 1.48) MJd) (4.12 1.19) MJ/d) were higher than those observed some studies...
INTRODUCTION Polypectomy at colonoscopy may be difficult or dangerous. In such instances colonic resection indicated. Novel combined laparoscopic-endoscopic procedures have the potential to allow safe extensive extramucosal resection, thus avoiding resection. Laparoscopic colon mobilisation provides a more favourable orientation for endoscopic mucosal and facilitates identification of possible perforation sites with immediate laparoscopic repair if necessary. This study aimed assess efficacy...
Abstract The focus on lymph node metastases (LNM) as the most important prognostic marker in colorectal cancer (CRC) has been challenged by finding that other types of locoregional spread, including tumor deposits (TDs), extramural venous invasion (EMVI), and perineural (PNI), also have significant impact. However, there are concerns about interobserver variation when differentiating between these features. Therefore, this study analyzed agreement pathologists assessing routine nodules based...
Abstract Aim This study aimed to assess the reliability of measurements and bony landmarks for rectosigmoid junction on MRI . Method The staging scans 100 patients were reviewed. mesorectum mesocolon was used identify rectum sigmoid. performance current metric or then compared against actual anatomical bowel segment. Results mean distance sigmoid take‐off from anal verge 12.6 cm (SD 1.8 cm, range 9.4–19.0 cm). At a cutoff 12 segment found be colon rather than in 35% patients. 15 16 84% 96%...
To review current practice in MRI-based nodal staging rectal cancer and assess the associated evidence. Nodal is less accurate than other MRI-detected prognostic markers such as circumferential resection margin status, extramural venous invasion T stage. Previous research has focused on matching MRI pathology findings but crucially N stage never been shown to have importance MRI. Recent pathological evidence suggests that tumour deposits may be more important status these can clearly...