A5000262619- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Anatomy and Medical Technology
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Anorectal Disease Treatments and Outcomes
- Autopsy Techniques and Outcomes
- Surgical Simulation and Training
- Forensic Entomology and Diptera Studies
- Advances in Oncology and Radiotherapy
- Diverticular Disease and Complications
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Paleopathology and ancient diseases
- Bladder and Urothelial Cancer Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Nutrition, Genetics, and Disease
- Forensic Anthropology and Bioarchaeology Studies
- Pelvic and Acetabular Injuries
Kingston Hospital
2023
Royal Marsden NHS Foundation Trust
2016-2022
Royal Marsden Hospital
2014-2021
Imperial College London
2016-2020
Institute of Oncology NN Petrov
2018
State Scientific Center of Coloproctology
2017
Russian Cancer Research Center NN Blokhin
2012-2017
Ministry of Health of the Russian Federation
2017
Croydon University Hospital
2016
Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. mrTRG pTRG were compared cancer patients from two phase II trials (EXPERT EXPERT-C). The agreement radiologist pathologist was assessed with weighted κ test while Kaplan–Meier method used to estimate survival outcomes. One hundred ninety-one included. Median time completion of neoadjuvant treatment pre-operative surgery 4.1 weeks (interquartile range (IQR):...
Pathological complete response after chemoradiotherapy for rectal cancer occurs in 10% to 30% of patients. The best method identify such patients remains unclear. Clinical assessment residual mucosal abnormality is considered the most accurate method. In our institution, magnetic resonance tumor regression grade performed as routine assess response.The purpose this study was compare sensitivity against detecting with a pathological response.Magnetic scores from reported posttreatment MRI...
Preoperative TNM stratification of colon cancer on computed tomography (CT) does not identify patients who are at high risk recurrence that could be selected for preoperative treatment.To evaluate the utility CT findings prognosis sigmoid cancer.This prognostic study used retrospective data from underwent bowel resection between January 1, 2006, and 2015, a tertiary care center receiving international national referrals colorectal cancer. Statistical analysis was performed in April 2019.Cox...
Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility organ preservation.MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 muscularis) versus >T2 tumours was compared gold standard pT stage T1sm1/2 ≤pT2 >pT2. N also compared. The MRI protocol employed a surface phased array coil high resolution (0.6×0.6×3 mm resolution). staging data were analysed from...
Abstract Aim The study aimed to establish the oncological outcome of patients who opted for close surveillance with or without adjuvant chemoradiotherapy rather than radical surgery after local excision ( LE ) early rectal cancer. Method Royal Marsden Hospital Rectal Cancer database was used identify cancer treated by primary from 2006 2015. All were entered in an intensive programme. Results Twenty‐eight 34 analysed had a high very risk residual disease predicted adverse histopathological...
Abstract Aim This study aimed to assess the reliability of measurements and bony landmarks for rectosigmoid junction on MRI . Method The staging scans 100 patients were reviewed. mesorectum mesocolon was used identify rectum sigmoid. performance current metric or then compared against actual anatomical bowel segment. Results mean distance sigmoid take‐off from anal verge 12.6 cm (SD 1.8 cm, range 9.4–19.0 cm). At a cutoff 12 segment found be colon rather than in 35% patients. 15 16 84% 96%...
The aim of this study was to investigate the feasibility short-course radiotherapy with oral capecitabine, hyperthermia and delayed surgery for neoadjuvant treatment rectal cancer.Patients clinically staged T2-3N0-2M0 primary cancer were included. All patients received 25 Gy in 5 fractions local metronidazole. Capecitabine 1000 mg/m2 twice a day given on days 1-14. Local hyperthermia, 41-45 °C 60 min, performed 3-5. Metronidazole 10 g/m2 administered per rectum 3 5. time interval not less...
The development of high-resolution magnetic resonance imaging (MRI) has resulted in the ability to clearly depict finer details rectal wall anatomy. Careful specialist assessment images obtained patients with significant polyps and early cancer lesions enables identification that are confined bowel amenable organ preserving local excision. Currently, one-third screen detected cancers limited without nodal spread yet more than 90% undergo major excision surgery resulting loss function,...
Abstract Aim Continuity of the mesentery has recently been established and may provide an anatomical basis for optimal colorectal resectional surgery. Preliminary data from operative specimen measurements suggest there is a tapering in distal sigmoid. A mesenteric waist this area be risk factor local recurrence cancer. This study aimed to investigate characteristics at junction. Method In cross‐sectional study, 20 patients were recruited. After planned resection, surgical specimens scanned...
It is widely believed that small rectal tumors are more likely to have a good response neoadjuvant treatment, which may influence the selection of patients for 'watch and wait' strategy.The aim this study was investigate whether there relationship between baseline tumor length on magnetic resonance imaging (MRI) chemoradiotherapy.The 96 with locally advanced cancer randomised (2:1-intervention:control) in TRIGGER feasibility where eligible. Baseline defined as maximal cranio-caudal MRI (mm)...
Objective : to evaluate the results of “watch and wait” approach for rectal cancer patients with complete clinical response after neoadjuvant chemoradiotherapy (CRT) followed by consolidation chemotherapy. Materials methods . Between 2013 2016, 130 who were diagnosed stage T2N0–1M0–T3(CRM+)–4N0–2M0 middle low treated CRT (single dose 2 Gy a total 50–54 concominant capecitabine 850 mg/m2 /day radiotherapy) chemotherapy (CapOx) (capecitabine 2000 14 days oxaliplatin intravenous once in 3...
Our study evaluated whether an MRI reporting system highlighting areas of contiguous and discontinuous extramural venous invasion (EMVI) can improve the accuracy gross tumour volume (GTV) delineation. Initially, 27 consecutive patients with locally advanced rectal cancer treated between 2012 2014 were evaluated. We used proforma that documented position primary tumour, lymph nodes EMVI. The new GTVs delineated compared historical radiotherapy treatment volumes to identify frequency GTV...