The aim of this study was to investigate the feasibility short-course radiotherapy with oral capecitabine, hyperthermia and delayed surgery for neoadjuvant treatment rectal cancer.Patients clinically staged T2-3N0-2M0 primary cancer were included. All patients received 25 Gy in 5 fractions local metronidazole. Capecitabine 1000 mg/m2 twice a day given on days 1-14. Local hyperthermia, 41-45 °C 60 min, performed 3-5. Metronidazole 10 g/m2 administered per rectum 3 5. time interval not less...

Aim. To evaluate technical features, safety and efficiency of radiofrequency ablation in tumor strictures extrahepatic bile ducts. Materials methods. An ongoing prospective observational study from September 2022 to June 2023 enrolled patients with unresectable duct tumors. Examination involved esophagogastroduodenoscopy, endoscopic ultrasound, retrograde cholangiopancreatography video choledochoscopy biopsy. Ductalradiofrequency polymeric or self-expanding metallic stent placement was...

Objective : to evaluate efficacy and safety of the short-course radiotherapy combined with capecitabine chemotherapy, intracavitary hyperthermia delayed surgical treatment as neoadjuvant therapy rectal cancer Materials methods . Patients T2–3N0–2M0 newly diagnosed were included. All patients received total dose 25 Gy in several fractions 5 each, along metronidazole local hyperthermia. Capecitabine (1000 mg/m2 ) was administrated twice daily on days 1–14. Local (41–45 °С, 60 min) applied 3–5....

рак прямой кишки

Complete mesocolic excision (CME) appears to be a relatively new concept for colon cancer. The purpose is evaluate the results of CME with high vascular ligation (D3 lymph node dissection) right presented study identifies possible risks and advantages proposed method, as well role laparoscopic approach.The article included data from 39 patients cancer, TNM stage I-III, operated on between November 2015 December 2016 in oncoproctology Department Blokhin Cancer Research Center. analysis main...

Background . Malignant colonic obstruction (MCO) it is one of the most common and severe complications colon rectal cancer. The mechanisms underlying MCO development include impairments in motor, secretory resorptive functions intestine, disorders water-electrolyte metabolism, endotoxicosis, compartment syndrome. All these conditions significantly reduce patient survival. Objective: to compare outcomes stenting patients with primary secondary tumors assess efficacy surgical treatment....

A new combined treatment scheme with short-course chemoradiotherapy and 2 selective radiosensitizers (metronidazole in a polymeric composition local hyperthermia) is investigated this article. Material methods. 77 T1–3N0–2M0 rectal cancer patients data was analyzed. All received 5 Ч Gy radiotherapy capecitabine 1300 mg/m2 days 1–5 per os radiosensitization hyperthermia metronidazole. Results. Investigated has acceptable toxicity leads to high control rate (none of the experienced...

Objectives : to assess the feasibility of a combination intensity-modulated radiation therapy (IMRT) with triplet chemotherapy paclitaxel, capecitabine, and mitomycin C in treatment patients anal cancer, evaluate toxicity proposed regimen. Materials methods . All included study had stage I–IIIB cancer. underwent IMRT radiotherapy 52–58 Gy (the dosage is calculated according T symbol) by 1.8 2.2 fractions daily. The scheme includes 10 mg/m2 on day 1, paclitaxel 45 days 3, 10, 17, 24, 31,...

Parametrium is a unique structure. Its definition has undergone significant changes throughout the evolution of concepts on anatomy, embryology, and surgery pelvis. Knowledge parametrium anatomy very important not only for surgeons dealing with female reproductive system, but also involved in treatment rectal cancer. For example, an outdated anatomical term “lateral ligaments rectum” still widely used by gynecologic oncologists considered as part parametrium. Combination surgeries cancer...

Background. The aim of this study was to compare short and long-term outcomes after neoadjuvant short-course chemoradiotherapy with capecitabine ot tegafur for operable rectal cancer. Materials methods. Patients histologycally verified Т3N0M0, Т2–3N1–2M0 cancer, who underwent 5 × Gy radiotherapy local 41–45 °C hyperthermia on days 3–5 metronidazole 10 g/m2 per rectum 3, were randomized receive 1000 mg/m2 bid os 1–14 or 400 1–21. Toxicity, tumor regression, sphincter preservation rate...

Presente d article is a review of domestic and foreign literature on the application radiomodifying drugs with electron-affinic properties (metronidazole its derivatives) aim increasing effectiveness radiation therapy. The mechanism action described. Special attention paid to creation new medicinal form metronidazole hydrogel-based biopolymer inclusion in combined treatment resectable locally advanced rectal cancer.

Background. Сomparative assessment of long-term oncologic outcomes surgical and combined treatment patients with upper rectal cancer. Materials methods. Patients aged > 18 histologycally verified T1–4N0–2M0 cancer were included. In group A received neoadjuvant chemoradiotherapy 25 Gy in 5 fractions capecitabine 850 mg/m2 bid per os on radiation days surgery. B surgery alone. Results. From january 2004 to december 2014, we selected 227 archival cases Group was 103 (45.4 %) – 123 (54.6 %)....

A rare clinical presentation of colorectal cancer bone metastases is discussed in this article. Data on incidence and possible mechanism isolated demonstrated, treatment options based different clinics experience discussed.

Objective: to improve the results of treatment in patients with squamous cell carcinoma anal canal, by creating a new combination option, and increase rate organ-sparing treatment. Subjects methods. A option for canal was created, which involved radiotherapy multiple radio modification program (ultrahigh-frequency (UHF) hyperthermia local metronidazole (MZ) injection systemic polychemotherapy) (RF patent No. 2427399 “A canal” registered on 27 August 2011). To evaluate created latter analyzed...

Preoperative chemoradiotherapy and surgery for low rectal cancer involving anorectal region are discussed in this article. Subjects .and .methods . 42 patients were included study, 18 received neoadjuvant 5 × Gy 24 had chemo-radiotherapy up to 40 4 fractions. Results Treatment acceptable toxicity levels with grade III of 11.1 % 8.3 accordingly. 20.8 pathological complete response following chemoradiotherapy. 22.2 group intershinctering resections comparing 75 group. No local or distant...

Safety and efficacy of intrarectal 5-fluoruracil in combined treatment localized rectal cancer was investigated this article. Our data supports safety, economical simplicity use method. It improves sphincter preservation rate patients with distal cancer, does not increase surgical mortality morbidity, leads to high tumor regression rate, local control decreases distant failure rate.

A large part of basic research including medical area studies transportation and delivery drugs directly to the organs, tissues cells. This interest has been caused by many reasons, above all, huge economic benefits directed transport, reduced side effects significant reduction therapeutic drug doses. LLC «KOLETEX» designs manufactures gels for targeted - «Kolegel» with various drugs, aim improve effectiveness radiotherapy prevent radiation reactions. These are widely used in major oncology...

INTRODUCTION: there is a lack of information chemoradiotherapy (CRT) efficacy in signet ring cell carcinoma the rectum (SRCCR). The aim our research was to investigate preoperative CRT patients with SRCCR. PATIENTS AND METHODS: we conducted retrospective analysis medical records from archive Research Institute FSBI “N.N. Blokhin Cancer Center” Ministry Health Russia and multicenter registry Russian Society Specialists Colorectal (RSSCC) 2000 2020 included study group histologically confirmed...