Introduction . Gastric cancer is a high burden on the healthcare system due to 1 million new cases every year. Most of these are diagnosed at late stage. Aim. The aim this research perform epidemiological analysis about gastric signet ring cell carcinoma in Tyumen region. Materials and methods Used data was taken from regional – registers medical center “Medical City”, Tyumen, Russia, which includes 2012 2021. histological tumor develops accordance with international classification stomach...

В статье представлена характеристика генетически обусловленных аденоматозно- и гамартомно-полипозных наследственных синдромов (семейного аденоматозного полипоза, Гарднера, Туркота, Пейтца–Егерса) широкий спектр их проявлений у детей. Современные данные молекулярно-го патогенеза указывают на то, что каждый из них имеет свою генетическую основу. Приведены сведения о фенотип-генотип корреляции, которая может служить ориентиром не только варианта проявления заболевания, но возможной его тяжести;...

A rationale for cytoreductive surgery in colorectal cancer patients with multiple liver metastases is discussed the article. Not only does it improve their quality of life and prevent life-threatening complications, but also facilitates further systemic treatment. Symptomatic (colostomies bypass surgery) not treatment outcome independent from additional Our results demonstrate that chemotherapy 2 or more active drugs after significantly improves results. Rationale use chemoradiotherapy...

Purpose: To study the capabilities of new radiopharmaceutical 99mTc-sentiscan in visualization sentinel lymph nodes patients with breast cancer. Material and methods: A survey 178 people diagnosed Patients were divided into two groups depending on route administration radiopharmaceutical. The day before surgical treatment, all subjects injected a using syringe an activity no more than 120 MBq, volume 0.3‒0.4 ml. visualized marked skin patented device – «Device for external marking during...

Anaplastic thyroid cancer is the rarest and most aggressive form of cancer. It comprises 1-2 % all cases characterized by rapid growth. median survival patients with this pathology about 5 months. Clinical manifestations disease are deformation in neck area, progressive respiratory distress, dysphagia. The article describes a clinical case response unresectable, BRAF -negative, PD-L1-positive (programmed death-ligand 1) anaplastic to immunotherapy pembrolizumab.

Sarcoma is a group of rare malignant tumors characterized by aggressive growth, active metastasis, and rapid recurrence the disease. Localized in any part body, mainly limbs. Ewing's sarcoma head neck area challenge for multidisciplinary team specialists. The tumor has little sensitivity to conservative methods special treatment it necessary apply large surgical treatment. To preserve quality life patient during operations on organs neck, reconstructive are required. article presents...

Introduction . Cervical cancer (CC) remains the most common in women worldwide. However, effective and specific biomarkers for diagnosis prognosis of cervical are yet to be found. In recent years, potential circular RNAs (circRNAs) as new diagnostic, prognostic therapeutic tools has received much attention. The current study involved an in-depth bioinformatics research explore circRNA-microRNA (miRNA)-messenger RNA (mRNA) regulatory network order identify important molecular processes...

INTRODUCTION: Intracranial meningiomas are the most common considered benign tumors of central nervous system with clinically aggressive behavior. Meningiomas account for up to 36% all brain tumors. Metastases, highly malignant lesions an undetermined incidence World Health Organization. It is believed that 30% adult patients cancer one localization or another suffer from secondary brain. The vast majority originate coverings brain, and more than 90% solitary. meningeal metastases occur in...

Background. Splenosis, or heterotopic autotransplantation of spleen tissue, is a benign disease, occurring in patient after splenectomy. This formation demands correct differential diagnosis because it often diagnosed as tumor. Main methods splenosis are ultrasound inspection, CT, MRI, but detailed anamnesis also important to set the diagnosis. The clinical case this report aimed show importance timely and which will allow avoid unnecessary invasive diagnostic procedures, late decreasing...

Objective : to analyze short-term and long-term outcomes of surgical, combination, comprehensive treatment in patients with metastatic rectal cancer. Materials methods . We performed a retrospective analysis prospectively collected data on the cancer receiving combination (surgery + chemotherapy), or (chemoradiotherapy surgery chemotherapy) Department Proctology at N.N. Blokhin National Medical Research Center Oncology, Ministry Health Russia, between 1999 2015. assessed overall survival,...

A new combined treatment scheme with short-course chemoradiotherapy and 2 selective radiosensitizers (metronidazole in a polymeric composition local hyperthermia) is investigated this article. Material methods. 77 T1–3N0–2M0 rectal cancer patients data was analyzed. All received 5 Ч Gy radiotherapy capecitabine 1300 mg/m2 days 1–5 per os radiosensitization hyperthermia metronidazole. Results. Investigated has acceptable toxicity leads to high control rate (none of the experienced...

In last two decades, transanal endoscopic microsurgery (TEM) in treatment of both benign and malignant tumor rectum is actively developing. The aim this review was to describe the current status interventions. Due low level recurrens (mean about 6 %) TEM has become method choice for removal rectal adenomas. Several studies have demonstrated benefits cases early T1 cancer compared conventional resection. However, more invasive adenocarcinomas performing remains controversial, but it’s very...

More than 200 years of laparoscopic surgery history from Avicenna to modern days is presented in this article. Based on a large literature review feasibility and significance minimally invasive techniques different fields was demonstrated. The rationale using laporoscopic oncoproctology demonstrated several clinical trials along with possibility follow key rules oncologic (high vascular ligation, lymph node dissection, no touch technique) laparoscopically. This results allow us view the...

The problem of wound closure after abdominoperineal resection to treat oncological diseases remains unsolved. Formation a primary suture in the perineal can lead multiple postoperative complications: seroma, abscess, disruption with subsequent hernia. Chemoradiation therapy as standard for locally advanced rectal or anal cancer doesn't improve results treatment wounds and increases duration their healing. Currently, surgeons have several reconstructive plastic techniques both direct...

Background . Comparative assessment of the long-term oncological results extended, combined and standard surgical interventions. Materials methods The study included women with histologically verified ovarian cancer T3—4N0—1M0—1. Group A (experimental) patients underwent advanced interventions; group B (control) In postoperative period, all received 6 courses polychemotherapy a combination platinum taxanes. authors compared frequency achieving optimal conditionally radical operations after...

Diseases desperate grown; By appliances are relieved. William Shakespeare «Hamlet» (1601) The article describes the main stages of development sphincter-saving surgery for rectal cancer. An historical look at this issue from standpoint research past years in our country and abroad, as well analysis current sphincter-preserving future directions area.

Diagnostic and treatment of rectal cancer local recurrences, risk factors tactics are discussed in this article. Chemoradio-therapy is a method choice as the first stage for patient group, however its application limited by pelvic radiotherapy anamnesis. Surgery only potentially curative treatment, but it should be applied patients with high probability R0-resection.

The article considers the possibility of sphincter sparing surgery in patients with negative risk factors, such as localization low third and lesion lateral lymph nodes. Combined treatment improved surgical approach allowed to achieve positive oncological functional results. discussion provides an analysis publications devoted various approaches rectal cancer extended pelvic node dissection neoadjuvant chemoradiotherapy.