A5078293496- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advances in Oncology and Radiotherapy
- Effects of Radiation Exposure
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Pleural and Pulmonary Diseases
- Breast Cancer Treatment Studies
- Nonmelanoma Skin Cancer Studies
- Occupational and environmental lung diseases
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Anorectal Disease Treatments and Outcomes
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
Ministry of Health of the Russian Federation
2018-2024
National Medical Research Center of Cardiology
2022
Ministry of Health
2020-2021
Hospital Universitario Ramón y Cajal
2018
Asahi University
2018
Russian Cancer Research Center NN Blokhin
2015-2016
Cancer Research Center
2014-2015
Cell Signaling Technology (United States)
2011
Hydrometeorological Research Centre of Russian Federation
2001
PhosphoSitePlus (http://www.phosphosite.org) is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human mouse proteins. It encompasses 1 30 000 non-redundant modification sites, phosphorylation, ubiquitinylation acetylation. The interface designed clarity ease navigation. From the home page, users can launch simple or complex searches browse high-throughput data sets by disease, tissue cell...
The aim of the study was to improve treatment outcomes for patients with locally advanced recurrent basal cell and squamous skin carcinomas face. Material methods. A total 26 (n=21) (n=5) were treated radiotherapy (2–2.5 Gy daily fractions a dose 60–70 Gy, 5 days week) in combination local freezing tumor. Local cooling tumor temperature tissue performed 10–15 minutes before each session radiation therapy using liquid nitrogen cryo-preservation equipment. Patients cancer who had received...
Hypofractionated radiotherapy in the treatment of breast cancer patients has a signifiant advantage over conventional fractionation due to shorter duration course while maintaining its antitumor effiacy. Usage hypofractionated regimens may be restricted with immediate reconstruction because higher rate complications. The aim this study is evaluate incidence complications reconstructed after radiotherapy. involved 100 implant-based who underwent an adjuvant external beam radiation therapy...
Objective: to analyze treatment outcomes in patients with locally advanced rectal cancer that received various combinations of neoadjuvant chemotherapy and chemoradiotherapy. Materials methods . In this retrospective study, we analyzed a cohort prospectively recruited stage mrT3(CRM+)/ T4N0–2M0 cancer. Participants were divided into three groups. Patients Group 1 preoperative longcourse radiotherapy given concurrently capecitabine, followed by 2–6 cycles consolidation capecitabine...
Background. Hypofractionated radiation therapy is a standard radical approach for treatment of patients with localized prostate cancer low and intermediate risk. Clinical practice applying this in high very risk progression has not been established. Aim: improving the effectiveness hormonal/radiation using an original radiotherapy technique. Materials methods. In 2012, new technique hypofractionated based on simultaneous integrated boost aimed at prostate, seminal vesicles, regional lymph...
Background. Salvage radiation therapy (SRT) is the main treatment option for patients with biochemical and/or locoregional recurrence of prostate cancer without signs distant metastasis after radical prostatectomy (RP). This prospective study demonstrates long-term results SRT in this category using modern technologies and radiotherapy techniques. Aim. To improve effectiveness no RP through improvement techniques identification prognostic factors. Materials methods. A single-center phase II...
Modern radiotherapy is performed with sophisticated equipment that requires highly qualified professionals. In the Russian Federation responsibilities of Radiation Therapy Technologists (RTTs) are carried out by medical nurses who receive on-the-job training. The article discusses problems RTT education and training, describes our own teaching experience suggests further development for national system in Russia.
Introduction: Nowadays the stereotactic radiotherapy (SRT) of clinical stage I-II lung cancer patients is choice treatment modality for functionally inoperable patients. It shows safety and high efficiency in achieving local control. Though there a range unsolved issues connected with prediction frequency complications, an integration new technologies planning process allows widening search predictive factors. Material methods. Since 2014, 39 (17 T1N0M0 patients, 22 T2N0M0 patients) I-IIa...
Purpose/Objective: Optimal radiotherapy utilization (RTU) rate has been studied for developed countries following an evidence-based, criterion-based method or based on assessment of current practice.In Australia, it determined to be 52.3% in 2003 later adjusted 48.3% 2012.For developing countries, estimates the proportion cancer patients who require can estimated from distribution types and stages.The purpose this project was assess optimal RTU rates 9 middle-income evidence method.Materials...
Objectives : to assess the feasibility of a combination intensity-modulated radiation therapy (IMRT) with triplet chemotherapy paclitaxel, capecitabine, and mitomycin C in treatment patients anal cancer, evaluate toxicity proposed regimen. Materials methods . All included study had stage I–IIIB cancer. underwent IMRT radiotherapy 52–58 Gy (the dosage is calculated according T symbol) by 1.8 2.2 fractions daily. The scheme includes 10 mg/m2 on day 1, paclitaxel 45 days 3, 10, 17, 24, 31,...
The aim of the study: to increase frequency achieving pathologic complete response and disease-free survival in investigational group patients with locally advanced rectal cancer T3(MRF+)–4N0–2M0 by developing a new strategy for neoadjuvant therapy. Materials methods. In total, 414 were assigned treatment. Control I included 89 who underwent radiotherapy (RT) 52–56 Gy/26–28 fractions concurrent capecitabine twice daily 5 days per week. II 160 RT week oxaliplatin once week, during course RT....
Material and methods: Since 2014, 33 patients with lung cancer of clinical stage I-IIa (cT1N0M0 - 12 patients, T2N0M0 21 patients) have undergone SRT. Verification tumor process was obtained in 30 patients. A third (n = 10) had a history metachronic primary-multiple tumors 31 peripheral cancer. The used variants SRT fractionation were as followed: 10Gr x 5 fractions 22) 7Gr 8 11) BED 100Gy. Results: With median follow-up months (range 3-37 months), 4 (12 %) within the first year...
Objective: to evaluate the effectiveness of salvage radiotherapy in patients with recurrent prostate cancer after radical prostatectomy. Materials and methods. In period from March 2009 January 2015, 92 biochemical recurrences prostatectomy underwent classic fractionation hypofractionation radiation dose. Results conclusion. Median follow-up duration was 40 months (12–78 months). Overall survival 100 %. Local control One (1), 2, 3-year disease-free whole patient group 96, 91, 86 %; it 98,...
Objective: to evaluate therapeutic pathomorphosis and Tand N-downstaging in response various polyradiomodification regimens used the combination therapy for rectal cancer. Materials methods. A total of 241 patients received cancer using 4 different regimens. We assessed tumor downstaging these patients. Eighty-two participants (34 %) underwent with a 14-day course capecitabine (Cap) given dose (2 g/m2body surface) (Cap14 + metronidazole (MZ) Cap14 MZ microwave hyperthermia (MW-HT)), whereas...
Purpose. Control of pain syndrome in patients with locally advanced and recurrent pancreatic cancer using stereotactic radiation therapy (SBRT).
 Materials methods. Our clinical observations relate to 103 (LAPC)and who received the radiological unit NIITs NMI. NN Blokhin "in periods: 2000-2010. 2010-2015. The first group consisted 77 non-resectable cancer, which (1a subgroup), 30 radiotherapy a classical fractionation regimen 54-60 Gy/5 fraction, 40 (1b subgroup) mode hypofractionation....
The purpose of study is to evaluate the role dynamic contrast intensification as a constituent multi-parametric MR-therapy in diagnostic clinical recurrence prostate cancer and optimization salutary X-ray therapy. Materials method. sampling consisted 89 patients with marker (prostate specific antigen) after radical ectomy. preliminary examination established no distant metastases. MR-imaging pelvis minor was applied both before therapy 6 months later treatment control. In 44 patients’...
The study objective is to determine advisability of radiation therapy in patients with recurrent prostate cancer after radical prostatectomy. Materials and methods. In our research 92 were treated by salvage median follow up 48 months. Results. rates 1, 2 3 years disease-free survival 96, 91 86 %. We received that specific antigen doubling time <6 months >0.5 ng/ml before statistical significance associated biochemical failure. results indicate two main negative factors the prognosis...
Objective : to improve the outcomes of combination treatment patients with rectal cancer using polyradiomodification and short courses neoadjuvant radiotheragy. Materials methods . A total 905patients were included into this retrospective study based on data retrieved from a prospective database. Of them, 241 underwent (CT + PRM); 271 preoperative radiotherapy alone (CT); 393patients surgical only (ST). Combination course dose 25 Gy delivered in 5 fractions (5 each), administration...
The main method of treating rare mesenchymal tumors PEComas is surgical removal the tumor and external-beam radiation therapy has historically been considered ineffective. However, individual cases in foreign literature as well this article authors’ experience form clinical case provided it shows possibility achieving some anti-tumor effect due to use aggressive variants therapy. variations stereotactic radiotherapy with high dose per fraction sum an neoadjuvant definitive treatment looks promising.
Objective: to analyze the outcomes of sphincter-sparing surgeries in patients with advanced distal rectal cancer depending on therapy they receive. Materials and methods. This study included 289 (stage T3N0–2M0) who have undergone surgeries. Patients were divided into three groups according their treatment scheme. In group 1, we used combination that a short course neoadjuvant radiotherapy supplemented by 3 multidirectional radiomodifiers (local microwave hyperthermia, administration...
Objective: comparison of the effectiveness results neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer using classical and hypofractionated schedule radiation therapy. Materials methods. This study is based on a retrospective analysis database (T3C–D, positive circumferential resection margin or T4) who underwent prolonged course followed by surgery. The were divided into two groups: first (main) group, 71 received hypofractionation as part treatment (4 Gy × 40 Gy,...
To increase the effectiveness of combined treatment in patients with rectal cancer and moderate risk progression based on concept polyradiomodification (PRM).The study included 337 tumor progression. A short course radiotherapy (cRT) (5x5 Gy) several radiomodifiers (cRT+PRM) was performed 147 (43.6%) patients. Other 190 (56.4%) underwent cRT. The following radio modifiers were used: three-time application local microwave hyperthermia (Yacht-3 or Yacht-4 devices), two-time intrarectal...