A5063590598- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple and Secondary Primary Cancers
- Metastasis and carcinoma case studies
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Myasthenia Gravis and Thymoma
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal disorders and treatments
- Vascular Tumors and Angiosarcomas
- Abdominal Surgery and Complications
- Cancer Cells and Metastasis
- Esophageal and GI Pathology
- Hernia repair and management
- Cardiac tumors and thrombi
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2017-2024
Ministry of Health of the Russian Federation
2017-2024
Federal State Budgetary Institution "Center for Expertise and Quality Control of Medical Care"
2018
Background: Differences in the embryonic development of colonic mucosa determine physiological embryonic-anatomical asymmetry its structure and can manifest themselves via different molecular phenotypes (expression profiles) colon segments. These characteristics are hypothesized to differences carcinogenesis mechanisms influence prognosis right- or left-sided colorectal cancer (CRC). Studies tumors depending on their localization may be interest for assessment choice treatment CRC.
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To summarize the results of pancreaticoduodenectomy (PD) for pancreatic tumors and complications chronic pancreatitis regarding prediction prevention postoperative complications.There were 336 PD procedures between 2016 mid-2022 in two centers. We assessed factors influencing specific (postoperative pancreatitis, fistula, gastric stasis, arrosive bleeding). Several risk distinguished: baseline disease tumor size, CT-signs a «soft» gland, intraoperative assessment pancreas, number functioning...
To evaluate the immediate results of enucleation pancreatic neuroendocrine tumors (pNETs).The (pNETs) were analyzed in 95 patients between 2016 and 2021. Functioning (mean size 16.8 mm) found 70 patients, non-functioning 25 - patients. Intraparenchymal 48 people, extraorganic lesion 47 patients.There 262 with pNETs who underwent various surgeries Various resections performed 167 (63.8%) cases, enucleations (36.2%) Traditional surgical approach was used 65 Pancreatic fistula occurred 21 (type...
Background: Ras oncogene mutations leading to hyperactivation of the MAPK/ERK signaling pathway occur in 25% all human tumors, and for gastrointestinal frequency amounts 60%. The introduction a Ras-GTPase inhibitor into clinical practice would increase effectiveness treatment socially significant diseases such as stomach intestinal cancer.
 Aim: To select optimal dose with subsequent assessment safety iRAS when administered patients tract including those peritoneal carcinomatosis.
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Aim . To identify the most appropriate surgical treatment method for patients with colorectal cancer metastases to liver by means of a comparative analysis immediate and long-term outcomes anatomical parenchyma-sparing resections. Materials methods A retrospective was conducted on 87 who underwent surgery between 2008 2023. The involved pseudorandomization eliminate influence unaccounted factors improve statistical validity study. Age, sex, body mass index, synchronous nature metastasis,...
Background. The search for molecular markers of colon diseases allowing highly specific and sensitive identification differentiation pathological processes is a clinically important problem. Expression levels genes responsible proliferation can reflect the changes in affected tissues. study objective to perform comparative analysis genetic proliferative activity benign malignant neoplasms colon. Materials methods. Analysis (CCND1, с-MYC, Ki-67, HER2neu, TERT) adenocarcinoma (n = 259),...
Background. Gastric cancer (GS ) is one of the most common and deadly cancers in Russia worldwide. In 40 % cases, GC diagnosed at an advanced stage, thus increasing risk distant metastasis. Peritoneal carcinomatosis from pathways dissemination, with a median survival time less than 6 months. Aim. To study various modern approaches to treatment peritoneal gastric cancer. Material Methods. Literature search was performed Medline, Cochrane Library, Elibrary, Scopus, PubMed systems. Results....
Vascular leiomyosarcoma (LMS) is an extremely rare disease. Venous lesion approximately 5 times more common than arterial. LMS usually found in retroperitoneal veins and inferior vena cava. Lesion of the splenic vein rare. A 52-year-old woman with recurrent abdominal pain reported article. Abdominal contrast-enhanced CT revealed a 6 cm tumor pancreatic tail. The patient underwent laparoscopic distal pancreatectomy splenectomy en bloc. Histological immunohistochemical studies originating from...
The paper describes a rare case of massive chyloperitoneum concurrent with chylothorax in female patient kidney cancer developing 4 years after multimodality treatment (surgery, radiotherapy, and immunotherapy). data available the literature on are analyzed detail. etiology this condition current approaches to its described. A algorithm is given detail treat patients similar clinical situation.
Objective: to analyze the outcomes of sphincter-sparing surgeries in patients with advanced distal rectal cancer depending on therapy they receive. Materials and methods. This study included 289 (stage T3N0–2M0) who have undergone surgeries. Patients were divided into three groups according their treatment scheme. In group 1, we used combination that a short course neoadjuvant radiotherapy supplemented by 3 multidirectional radiomodifiers (local microwave hyperthermia, administration...
The paper describes a clinical case of pancreaticoduodenectomy for pancreatic ductal adenocarcinoma with superior mesenteric vein resection without its reconstruction. This is the first study kind found in Russian-language literature. In total, 16 such observations have been described relevant world literature to date. A 74-year-old female patient was diagnosed head 1.1 × cm size adjacent vein. After four courses ineffective neoadjuvant therapy, tumor completely obliterated control...
A comparative analysis of molecular genetic phenotypes mucous membrane cells in five anatomical regions the colon a group healthy donors was conducted by comparing mRNA expression profiles 62 genes involved regulation vital cellular function. We used 181 biopsy samples morphologically unchanged colonic mucosa, obtained from (ascending, transverse-colon, descending, sigmoid) and rectum sections during prophylactic colonoscopy 58 with no pathology. The levels for apoptosis, proliferation,...
The paper describes a clinical case of successful combined modality treatment patient with pancreatic ductal adenocarcinoma extension to the superior mesenteric artery and vein. examination revealed an unresectable tumor. Twelve courses FOLFIRINOX therapy showed good results, upon which plan was changed typical pancreaticoduodenal resection performed. Pathological urT1N0M0R0, TRG 2. postoperative period uneventful. efficacy drug for has increased markedly in recent years. Neoadjuvant...
Background: during natural aging, cellular and molecular changes in the colonic mucosa contribute to chronic damage development of various neoplasia, including colorectal cancer (CRC). Aim: assess age peculiarities mRNA expression samples normal from parts colon. Patients Methods: study included 95 patients. Normal biopsies were derived videocolonoscopy different colon, i.e., right colon (n=91), left (n=95), rectum (n=87). In total, 273 examined. The relative level 63 genes potentially...
Introduction . The absence of specific clinical symptoms in the early stages colorectal cancer development leads to fact that a quarter patients who seek help for first time have metastatic stage disease. For timely detection pre-tumor disorders or hidden foci malignancy, possibilities modern molecular biological technologies are being actively studied today. Aim To develop method diagnosing tumor diseases colon based on genetic analysis morphologically unchanged intestinal epithelium...
We present a clinical case of pancreatoduodenal resection with en bloc superior mesenteric vein (SMV) without reconstruction. This represents an infrequent situation. Only 16 such cases are reported in world literature and no similar Russian-language literature. A 74-year female patient was diagnosed pancreatic ductal adenocarcinoma. After detailed examination via computer tomography (CT) tumor-caused compression SMV found. 4 courses neoadjuvant chemotherapy, tumor has totally obliterated...
Purpose. To assess the possibilities of methods radiation diagnosis in recognition and staging gastric cancer. Material methods. The results inspection 307 patients with cancer a stomach at which endoscopic, radiological computer tomography researches on purpose, both primary cancer, establishment process have been executed analyzed from 2014 to 2017. Results. At research proximal is revealed 63 (20,5%) patients, body – 202 (65.8%) distally 42 (13.7%) patients. In all cases we managed...
To choose optimal technique of esophagojejunostomy in stomach cancer regarding reliability, functionality and simplicity.145 patients with grade I-IV were enrolled. They divided into 2 groups depending on the type anastomosis (manual or hardware).There no significant differences between incidence failure, anastomotic stricture reflux-esophagitis long-term postoperative period. At same time, duration reconstructive stage hardware was 26±11.3 min, whereas for manual - 72±21.9 min (p<0.0001)...
Background: About 15 to 25% of colorectal cancer patients have synchronous liver metastasis at diagnosis. In the recent years, strategy simultaneous removal and metastases has been preferred. Development minimally invasive technologies in abdominal hepatopancreatobiliary surgery allows for active advance fully laparoscopic approach these types interventions. Aim: Comparative analysis isolated resections performed Department Surgery, Russian Research Center Roentgenoradiology (Moscow)....