A5091759118- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
- Colorectal Cancer Treatments and Studies
- Carcinogens and Genotoxicity Assessment
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Cervical Cancer and HPV Research
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2009-2023
Ministry of Health of the Russian Federation
2019-2020
Background: Differences in the embryonic development of colonic mucosa determine physiological embryonic-anatomical asymmetry its structure and can manifest themselves via different molecular phenotypes (expression profiles) colon segments. These characteristics are hypothesized to differences carcinogenesis mechanisms influence prognosis right- or left-sided colorectal cancer (CRC). Studies tumors depending on their localization may be interest for assessment choice treatment CRC.
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Matrix metalloproteinases (MMPs) responsible for the extracellular matrix remodeling, activation of various growth factors, and angiogenesis play an important role in colorectal cancer (CRC) development. In present work comparative analysis MMP-7, -8, -9, -11 mRNA as well Ki-67 proliferation marker tissue samples obtained from CRC patients healthy individuals. Employing real time PCR method expression levels several MMPs (MMP-7, -11) cell marker, Ki-67, were simultaneously measured 256 112...
Background. The search for molecular markers of colon diseases allowing highly specific and sensitive identification differentiation pathological processes is a clinically important problem. Expression levels genes responsible proliferation can reflect the changes in affected tissues. study objective to perform comparative analysis genetic proliferative activity benign malignant neoplasms colon. Materials methods. Analysis (CCND1, с-MYC, Ki-67, HER2neu, TERT) adenocarcinoma (n = 259),...
Introduction. Adjuvant systemic therapy remains one of the main options for treating breast cancer. Results standard immunohistochemical studies are not always a criterion selecting therapy. Nowadays, multigene expression analysis is actively used to predict response chemotherapy in patients with earlystage We studied 24-gene multi-gene panel typing Material and Methods. A prospective 199 cancer (T1–3N0–3M0) was carried out. Surgical specimens were using immunohistochemistry (IHC) RT-PCR...
A comparative analysis of molecular genetic phenotypes mucous membrane cells in five anatomical regions the colon a group healthy donors was conducted by comparing mRNA expression profiles 62 genes involved regulation vital cellular function. We used 181 biopsy samples morphologically unchanged colonic mucosa, obtained from (ascending, transverse-colon, descending, sigmoid) and rectum sections during prophylactic colonoscopy 58 with no pathology. The levels for apoptosis, proliferation,...
Background: during natural aging, cellular and molecular changes in the colonic mucosa contribute to chronic damage development of various neoplasia, including colorectal cancer (CRC). Aim: assess age peculiarities mRNA expression samples normal from parts colon. Patients Methods: study included 95 patients. Normal biopsies were derived videocolonoscopy different colon, i.e., right colon (n=91), left (n=95), rectum (n=87). In total, 273 examined. The relative level 63 genes potentially...
Introduction . The absence of specific clinical symptoms in the early stages colorectal cancer development leads to fact that a quarter patients who seek help for first time have metastatic stage disease. For timely detection pre-tumor disorders or hidden foci malignancy, possibilities modern molecular biological technologies are being actively studied today. Aim To develop method diagnosing tumor diseases colon based on genetic analysis morphologically unchanged intestinal epithelium...
Ocenka progressirovaniya pozvolyaet realizovat' mery tretichnoj profilaktiki kolorektal'nogo raka (KRR), napravlennye na rannee vyyavlenie i svoevremennoe lechenie metastaticheskoj bolezni. Cel'yu issledovaniya bylo razrabotat' model' KRR s ispol'zovaniem patomorfologicheskih molekulyarno-geneticheskih harakteristik opuholi. U 223 pacientov v stadiyah T1-4N0-2M0 obrazcah iz opuholi byli opredeleny otnositel'nye urovni ekspressii mRNK 63 genov raznyh funkcional'nyh grupp. Mediana nablyudeniya...
СОПОСТАВИТЕЛЬНЫЙ АНАЛИЗ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИХ ХАРАКТЕРИСТИК ПЕРВИЧНОГО ОПУХОЛЕВОГО ОЧАГА И МЕТАСТАТИЧЕСКИХ ЛИМФАТИЧЕСКИХ УЗЛОВ ПРИ РАКЕ МОЛОЧНОЙ ЖЕЛЕЗЫ Владимир Константинович