A5076149459- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Reproductive Biology and Fertility
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Birth, Development, and Health
- Musculoskeletal Disorders and Rehabilitation
- Hip and Femur Fractures
- Metabolism and Genetic Disorders
- Cardiac Valve Diseases and Treatments
- Hip disorders and treatments
- Infant Nutrition and Health
- Venous Thromboembolism Diagnosis and Management
- Fatty Acid Research and Health
- Knee injuries and reconstruction techniques
- Atrial Fibrillation Management and Outcomes
- Diabetes Management and Research
- Peripheral Artery Disease Management
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Renal and related cancers
- Metabolomics and Mass Spectrometry Studies
- Ovarian function and disorders
South Australian Health and Medical Research Institute
2017-2025
Australian Orthopaedic Association
2014-2022
University of South Australia
2017-2021
Health Net
2020
University of Notre Dame
2020
Mater Mothers' Hospital
2020
Flinders Medical Centre
2020
The University of Adelaide
2005-2018
Data Management (Italy)
2012
Queen Elizabeth Hospital
2005
Oocyte and embryo metabolism are closely linked with their subsequent developmental capacity. Lipids a potent source of cellular energy, yet little is known about lipid during oocyte maturation early development. Generation ATP from lipids occurs within mitochondria via beta-oxidation fatty acids, the rate-limiting step catalyzed by carnitine palmitoyl transferase I (CPT1B), process also requiring carnitine. We sought to investigate regulation role preimplantation Expression Cpt1b mRNA,...
Importance There remains a lack of randomized trials investigating aspirin monotherapy for symptomatic venous thromboembolism (VTE) prophylaxis following total hip arthroplasty (THA) or knee (TKA). Objective To determine whether was noninferior to enoxaparin in preventing VTE after THA TKA. Design, Setting, and Participants Cluster-randomized, crossover, registry-nested trial across 31 hospitals Australia. Clusters were performing greater than 250 TKA procedures annually. Patients (aged ≥18...
Previous studies have suggested that maternal supplementation with n−3 long-chain polyunsaturated fatty acids may reduce the incidence of preterm delivery but also prolong gestation beyond term; however, more data are needed regarding role in pregnancy.
New joint replacement prostheses are being continually introduced into the market. The underlying purpose of introduction new devices is to improve patient outcomes. This study was undertaken determine how many were associated with improved outcomes.Data obtained from a comprehensive national database. Outcome analysis performed on all hip and knee market between January 1, 2003, December 31, 2007, used at least 100 occasions. findings compared combined results three best performing...
This study aims to describe the pre- and postoperative self-reported health quality of life from a national cohort patients undergoing elective total conventional hip arthroplasty (THA) knee (TKA) in Australia. For context, these data will be compared with patient-reported outcome measures (PROMs) other international nation-wide registries.
The nutrient requirements and metabolic pathways used by the developing embryo transition from predominantly pyruvate during early cleavage stages to glucose at blastocyst; however, complexities involved in regulation of metabolism different developmental are not clear. aims this study were examine role malate-aspartate shuttle (MAS) mouse blastocyst consequences impaired on viability fetal placental growth. Eight-cell-stage embryos cultured presence MAS inhibitor amino-oxyacetate, with or...
For patient-reported outcome measures (PROMs) to provide meaningful information support clinical care, we need understand the magnitude of change that matters patients. The aim this study was estimate minimal clinically important changes (MCICs) for 12-item Hip disability and Osteoarthritis Outcome Score (HOOS-12) Knee injury (KOOS-12) among people undergoing joint replacement osteoarthritis.Individual-level data from Australian Orthopaedic Association National Joint Replacement Registry's...
Aims There is uncertainty over whether robotic-assisted surgery (RAS) or kinematic alignment (KA) improves outcomes in total knee arthroplasty (TKA). The Robotic-Assisted Surgery and Kinematic ALignment TKA trial (RASKAL) a registry-nested, multicentre, randomized, blinded, 2 × factorial involving approximately 300 patients. RASKAL will assess the effectiveness of RAS, KA, both to improve clinical, operative, functional, radiological, survivorship when compared computer-assisted (CAS)...
A limiting factor in every embryology laboratory is its capacity to grow 'normal' embryos. In human vitro fertilisation (IVF), there considerable awareness that the environment of itself can alter quality embryos produced and industry as a whole has moved towards implementation auditable management systems. Furthermore, some countries, such Australia, an established system mandatory for clinical IVF practice, but systems are less frequently found other laboratories. Although same challenges...
Abstract Background Preoperative immunonutrition has been proposed to reduce the duration of hospital stay and infective complications following major elective surgery in patients with gastrointestinal malignancy. A multicentre 2 × factorial RCT was conducted determine impact preoperative postoperative versus standard nutrition oesophageal cancer. Methods Patients were randomized before oesophagectomy (IMPACT®) isocaloric/isonitrogenous nutrition, then further after operation nutrition....
Femoral stems with exchangeable (modular) necks were introduced to offer surgeons an increased choice when determining the version, offset and length of femoral neck during total hip arthroplasty (THA). It was hoped that this would improve outcomes reduce complications, particularly dislocation. In 2010, Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) first reported rate revision after primary THA using neck. The aim study provide a more comprehensive...
Background Patient-reported outcome measures (PROMs) are commonly used to evaluate surgical in patients undergoing joint replacement surgery, however routine collection from the target population is often incomplete. Representative samples required allow inference sample population. Although higher capture rates desired, extent which this improves representativeness of not known. We aimed measure data collected using an electronic PROMs system with or without telephone call follow up, and...
Relatively little is known about the social distribution of total knee joint replacement (TKR) uptake in Australia. We examine associations between socioeconomic status (SES) and TKR performed for diagnosed osteoarthritis 2003–10 all Australian males females aged ≥30 yr. Data primary (n = 213,018, 57.4% female) were ascertained from a comprehensive national registry. Residential addresses matched to Census data identify area-level disadvantage, categorised into deciles. Estimated rates...
The collection of patient-reported outcome measures (PROMs) following arthroplasty is common. PROMs data programs seek to maximise completeness in order minimise selection bias and optimise representativeness the sample attained. We aimed determine if patient factors influence variation program between-hospitals.Using from a national registry program, we tested for associations between characteristics (age, sex, body mass index [BMI] American Society Anaesthesiologists [ASA] class) both...
The objective is to determine whether body mass index associated with patient-reported expectations and well-being before primary total hip or knee arthroplasty, outcomes 6 months after surgery.Data were obtained from the Australian Orthopaedic Association National Joint Replacement Registry. Outcome measures included pre-operative for post-operative mobility, joint pain health, pre- EQ-5D-5L, EQ-VAS, Oxford Hip/Knee Scores scales, perceived change satisfaction. Associations BMI assessed...
Abstract Aim This study assessed the responsiveness and convergent validity of two preference-based measures; newly developed cancer-specific EORTC Quality Life Utility Measure-Core 10 dimensions (QLU-C10D) relative to generic three-level version EuroQol 5 (EQ-5D-3L) in evaluating short-term health related quality life (HRQoL) outcomes after esophagectomy. Methods Participants were enrolled a multicentre randomised controlled trial determine impact preoperative postoperative immunonutrition...