A5059001354- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Congenital Diaphragmatic Hernia Studies
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Hernia repair and management
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Tracheal and airway disorders
- Classical Philosophy and Thought
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Potassium and Related Disorders
Flinders University
2015-2025
Flinders Medical Centre
2016-2025
Queen Elizabeth Hospital Birmingham
2022
University of Birmingham
2022
SUNY Upstate Medical University
2021
A.T. Still University
2020
University of King's College
2020
University of Cambridge
2020
Diversitech (United States)
2020
Royal Adelaide Hospital
2006-2016
Abstract Background Many patients with locally advanced gastro-oesophageal cancers are unable to complete adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy, raising questions about its therapeutic utility. The aim of this study was examine whether pathological response neoadjuvant FLOT can guide use. Methods Patients non-metastatic adenocarcinoma who received underwent surgery from 1 January 2017 2022 43 hospitals across 12 countries were analysed....
Abstract Background Preoperative immunonutrition has been proposed to reduce the duration of hospital stay and infective complications following major elective surgery in patients with gastrointestinal malignancy. A multicentre 2 × factorial RCT was conducted determine impact preoperative postoperative versus standard nutrition oesophageal cancer. Methods Patients were randomized before oesophagectomy (IMPACT®) isocaloric/isonitrogenous nutrition, then further after operation nutrition....
In Brief Objective: To determine the efficacy of endoscopic argon plasma coagulation (APC) for ablation Barrett esophagus. Summary Background Data: APC has been used to ablate However, long-term outcome this treatment is unknown. This study reports 5-year results from a randomized trial versus surveillance esophagus in patients who had undergone fundoplication gastroesophageal reflux. Methods: Fifty-eight with were undergo either using or ongoing surveillance. At mean 68 months after...
<b>Background and study aim:</b> Argon plasma coagulation (APC) has been used to ablate dysplastic nondysplastic Barrett's esophagus. We determined the longer-term efficacy of APC ablation within two randomized controlled trials versus surveillance for esophagus in patients whom gastroesophageal reflux was by either surgery or proton pump inhibitors. <b>Patients methods:</b> 129 (surgical trial 70, medical 59) with (nondysplastic low grade dysplasia) were randomly allocated using continuing...
Objective: To evaluate late outcomes from a randomized trial of division versus no short gastric vessels during laparoscopic Nissen fundoplication at up to 20 years follow-up. Background: is an established procedure for the treatment gastroesophageal reflux disease. Controversy about whether side effects such as dysphagia could be reduced by led establishment in 1994. Early results showed equivalent control and dysphagia, but more bloating after vessel division. Methods: A total 102 patients...
BACKGROUNDCirculating microRNAs (miRNAs) are potential biomarkers for many diseases.However, they can originate from non-disease specific sources, such as blood cells, and compromise the investigations miRNA biomarkers.While small extracellular vesicles (sEVs) have been suggested to provide a purer source of circulating miRNAs discovery, most suitable sample sEV biomarker studies has not defined. AIMTo compare profiles between matched serum plasma preparations determine their suitability...
This Delphi exercise aimed to gather consensus surrounding risk factors, diagnosis, and management of chyle leaks after esophagectomy develop recommendations for clinical practice.Chyle following malignancy are uncommon. Although they associated with increased morbidity mortality, diagnosis these patients remain controversial a challenge globally.This was modified delivered clinicians across the oesophagogastric anastomosis collaborative. A 5-staged iterative process used on practice,...
Abstract Aim This study assessed the responsiveness and convergent validity of two preference-based measures; newly developed cancer-specific EORTC Quality Life Utility Measure-Core 10 dimensions (QLU-C10D) relative to generic three-level version EuroQol 5 (EQ-5D-3L) in evaluating short-term health related quality life (HRQoL) outcomes after esophagectomy. Methods Participants were enrolled a multicentre randomised controlled trial determine impact preoperative postoperative immunonutrition...
Abstract Background To standardize management of upper gastrointestinal ( GI ) cancer in S outh A ustralia, a statewide video linked multidisciplinary team MDT meeting was established late 2009. Although s are recognized as standard care, it is important to audit their impact. Methods retrospective outcomes and recommendations for patients reviewed by the between 1 J anuary 2010 31 D ecember 2011 undertaken. The proportion with new malignancies within 2 weeks diagnosis were determined....
At a national level, understanding preventable mortality after oesophago-gastric cancer surgery can direct quality-improvement efforts. Accordingly, utilizing the Australian and New Zealand Audit of Surgical Mortality (ANZASM), we aimed to: (1) determine causes death following resections in Australia, (2) quantify proportion potentially deaths, (3) identify clinical management issues contributing to mortality.All in-hospital mortalities from 1 January 2010 31 December 2020 were analysed...
Background Volume–outcome relationships for mortality following oesophagectomy have been demonstrated in Europe and the USA, but not Australia or New Zealand. We determined whether higher volume hospitals achieve better outcomes Methods Administrative data contributing to Health Roundtable were analysed. Hospitals performing cancer from July 2008 June 2015 grouped according mean annual caseload: low (1–5), medium (6–11) high (12+) volume. Univariate multivariable analyses impact of on 30‐day...
Abstract Background With proton pump inhibitors and current sophisticated endoscopic techniques, the number of patients requiring surgical intervention for upper gastrointestinal bleeding has decreased considerably while trans‐arterial embolization is being used more often. There are few direct comparisons between effectiveness surgery embolization. Methods A retrospective study from two ustralian teaching hospitals who had or ( n = 103) severe haemorrhage 2004 2012 was carried out. Patient...