A5009780207- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hernia repair and management
- Esophageal and GI Pathology
- Hip and Femur Fractures
- Bacterial Identification and Susceptibility Testing
- Dermatology and Skin Diseases
- Male Breast Health Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Central Venous Catheters and Hemodialysis
- Photodynamic Therapy Research Studies
- Surgical Sutures and Adhesives
- Cancer and Skin Lesions
- Reconstructive Surgery and Microvascular Techniques
- Spondyloarthritis Studies and Treatments
- Surgical site infection prevention
- Venous Thromboembolism Diagnosis and Management
- Abdominal vascular conditions and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Diversity and Career in Medicine
- BRCA gene mutations in cancer
- Intestinal and Peritoneal Adhesions
- Psoriasis: Treatment and Pathogenesis
Lyell McEwin Hospital
2022-2024
University Hospital of Geneva
2008-2024
Flinders Medical Centre
2020
Swiss HIV Cohort Study
2009
University of California, Los Angeles
2007
Objectives: Plasma soluble inflammatory molecules are associated with the risk of ischaemic cardiovascular events. We investigated whether HIV replication modified levels these proteins in a combination antiretroviral therapy (cART) interruption trial. Method and results: In 145 HIV-infected Thai patients (62% women, median CD4 cell count 271 cells/μl, plasma HIV-RNA 4.66 log10 copies/ml) included Swiss–Thai–Australia Treatment Interruption Trial (STACCATO) trial, leptin, adiponectin,...
Efavirenz (EFV) causes neuropsychiatric side-effects and an unfavorable blood lipid profile. We investigated the effect of replacing EFV with raltegravir (RAL) on patient preference, daytime sleepiness, sleep quality, anxiety, levels.Switch-ER was a randomized, double-blind, cross-over study. Patients who tolerated EFV, less than 50 copies/ml HIV-RNA, were randomized into two groups: RAL-first group started RAL (400 mg twice daily) placebo, EFV-first (600 once placebo. After 2 weeks, both...
Abstract Background Many patients with locally advanced gastro-oesophageal cancers are unable to complete adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy, raising questions about its therapeutic utility. The aim of this study was examine whether pathological response neoadjuvant FLOT can guide use. Methods Patients non-metastatic adenocarcinoma who received underwent surgery from 1 January 2017 2022 43 hospitals across 12 countries were analysed....
Background and Objectives Combination antiretroviral therapy (cART) is changing, this may affect the type occurrence of side effects. We examined frequency lipodystrophy (LD) weight changes in relation to use specific drugs Swiss HIV Cohort Study (SHCS). Methods In SHCS, patients are followed twice a year scored by treating physician as having ‘fat accumulation’, loss’, or neither. Treatments, reasons for change thereof, recorded. Our study sample included all treated with cART between 2003...
Background: Efavirenz (EFV) causes neuropsychiatric side-effects and an unfavourable blood lipid profile. We investigated the effect of replacing EFV with etravirine (ETR) on patient preference, sleep, anxiety levels. Method: Study participants did not complain side-effects, had tolerated for at least 3 months, less than 50 copies/ml HIV-RNA. After randomization, ETR-first group started ETR (400 mg four times daily) EFV-placebo EFV-first ETR-placebo. 6 weeks, both groups switched to...
Background Nevirapine (NVP) is often prescribed once daily in clinical practice combination with a nucleoside backbone. We investigated the relationship of NVP dosing safety and efficacy. Methods Patients from Dutch AIDS Therapy Evaluation Netherlands (ATHENA) cohort study, Canadian HAART Observational Medical Research (HOMER) Swiss HIV Cohort Study (SHCS) using NVP-based therapy either or twice were included. Risk factors for discontinuing because hypersensitivity reactions (HSRs)...
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