A5070195306- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Gestational Diabetes Research and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Issues in Pregnancy
- HIV-related health complications and treatments
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Pulmonary Hypertension Research and Treatments
- HIV, Drug Use, Sexual Risk
- Birth, Development, and Health
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Gestational Trophoblastic Disease Studies
- Virology and Viral Diseases
- MRI in cancer diagnosis
- Hematological disorders and diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Cutaneous lymphoproliferative disorders research
- Pregnancy-related medical research
- Gynecological conditions and treatments
- Neurogenetic and Muscular Disorders Research
Maastricht University Medical Centre
2016-2025
Maastricht University
2018-2025
Frauenklinik Heidelberg
2024
German Center for Lung Research
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
University Hospital of Geneva
2000-2017
Bicêtre Hospital
2004
Hôpital Beau-Séjour
2004
Federal Office of Public Health
2000-2001
To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort aviremic HIV-positive patients. evaluate relevance HIV dementia scale to detect HANDs.Assessment HANDs with neuropsychological tests.Two hundred HIV-infected patients undetectable HIV-1 RNA concentrations plasma, no history major opportunistic infection central nervous system past 3 years, current use intravenous drugs, depression answered questionnaire designed elicit...
This study aimed to assess the long-term course of pulmonary arterial hypertension related infection with human immunodeficiency virus (PAHRH) and influence antiretroviral therapy (ART) on its characteristics. We retrospectively analyzed all 47 patients in Swiss HIV Cohort Study whom PAHRH was diagnosed. Among 35 who underwent follow-up Doppler echocardiography, right ventricular systolic pressure over atrial gradient increased by a median 25 mm Hg 9 had not received ART, decreased 3 12...
Objectives: To limit exposure to anti-HIV drugs and minimize risk of long-term side effects, studies have looked at the possibility simplified maintenance strategies. Ritonavir-boosted protease-inhibitor (PI)-monotherapies are an attractive alternative, but limited compartmental penetration PI remains a concern. Design: Non-comparative 24-week pilot study. Method: atazanavir (ATV/r) monotherapy administered fully suppressed patients (>3 month HIV RNA < 50 copies/ml). Plasma was obtained...
Gestational diabetes mellitus (GDM) is a pregnancy complication characterized by second trimester hyperglycemia. Untreated, GDM related to an increased risk for adverse outcomes. Both beta cell dysfunction and insulin resistance underlie impaired glucose tolerance. Understanding the dominant mechanism predisposing may be important provide effective treatment in order improve perinatal We hypothesize that rather predisposes GDM.A 75g oral tolerance test (OGTT) was performed on 2112...
Background and Objectives Combination antiretroviral therapy (cART) is changing, this may affect the type occurrence of side effects. We examined frequency lipodystrophy (LD) weight changes in relation to use specific drugs Swiss HIV Cohort Study (SHCS). Methods In SHCS, patients are followed twice a year scored by treating physician as having ‘fat accumulation’, loss’, or neither. Treatments, reasons for change thereof, recorded. Our study sample included all treated with cART between 2003...
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Despite increased cardiovascular (CV) disease risks after pre-eclampsia, guidelines remain indefinite on the necessity, timing, and frequency of CV risk assessment in these women. We aimed to provide prevalence-based recommendations systematic follow-up pre-eclampsia by evaluating age-related prevalence factors former pre-eclamptic women compared with a history normotensive gestation. A retrospective cohort study was performed amongst parous women, up 30 years postpartum. Prevalence...
Pre-eclampsia is a hypertensive complication of pregnancy that associated with an increased risk long-term cardiovascular and cerebrovascular disorders. Although the underlying mechanism persistent susceptibility to cerebral complications after pre-eclampsia remains largely unclear, impaired blood-brain barrier (BBB) integrity has been suggested precede several diseases. In this study, we aimed investigate BBB years pre-eclampsia.This was observational study premenopausal formerly...
In human immunodeficiency virus (HIV)–infected individuals, the immune response over time to yellow fever vaccination (YFV) and necessity for booster are not well understood. We studied 247 participants of Swiss HIV Cohort Study (SHCS) with a first YFV after diagnosis determined their responses at 1 year, 5 years, 10 years postvaccination by plaque reduction neutralization titers (PRNTs) in stored blood samples. A PRNT 1:≥10 was regarded as reactive protective. Predictors were analyzed...
Background Highly active antiretroviral therapy (HAART) may fail, especially in pre-treated patients. Objective To examine retrospectively whether heavily patients not responding to HAART at least once respond a salvage with abacavir, nucleoside reverse transcriptase inhibitor (NRTI) plus non-nucleoside analogue (NNRTI) and one or two protease inhibitors (PI). Patients We identified analysed followed the Swiss HIV Cohort Study > 1000 RNA copies/ml on HAART, naive abacavir who were switched...
Background: It is not known whether the risk of active tuberculosis disease varies with length time that individuals are infected HIV. Objective: To study how, independently CD4 T cell count, duration HIV infection. Methods: Using Poisson regression analysis, incidence and factors for were studied in 683 injecting drug users (IDU) a documented date seroconversion followed seven cohorts six European countries until 1998. Results: Overall was 11.5/1000 person-years. Adjusted count geographic...
Placental vascular disease, characterized by Maternal Vascular Malperfusion (MVM) lesions, is considered to be the underlying cause of pregnancy complications. Aim evaluate relationship between cumulative number MVM lesion types, and adverse pregnancy- neonatal outcomes.This retrospective cohort study included 272 women with singleton gestations who gave birth at a Dutch tertiary hospital 2017 2018 available placental histopathology reports. Analyzed according Amsterdam Workshop Group...
Objective To reconstruct the epidemiological relationships of HIV epidemics among injecting drug users (IDU) in western Europe. Methods env V3 sequences and data were obtained from 145 IDU who seroconverted three sequential periods: 1984–1988, 1989–1992 1993–1997. The phylogenetically analysed examined for signature patterns characteristic northern European IDU, including conserved GGC codon loop. Results Subpopulations genetically related strains observed Italy, France, Scotland Spain,...
Objectives To assess the safety of discontinuation primary prophylaxis in HIV-infected patients on antiretroviral combination therapy at high risk developing Pneumocystis carinii pneumonia. Design Prospective multicentre study. Patients and methods The incidence P. pneumonia after was studied 396 who experienced an increase their CD4 cell count to least 200 × 106/l 14% total lymphocytes; study population included 191 with a history counts below 100 (245 person-years) 144 plasma HIV RNA above...
Laurence Toutous-Trellu, MD; Shahnaz Abraham, Marc Pechere, Pierre Chavaz, Jan Lubbe, Veronique Schiffer, Bernard Hirschel, Jean-Hilaire Saurat, Vincent Piguet, MD, PhD; Departments of Dermatology and Venereology (Drs Piguet) Internal Medicine, Division Infectious Disease Hirschel), University Hospital Geneva, Switzerland.
A majority of recurrent pregnancy loss cases (RPL) remains unexplained. We hypothesized that complications in vascular and metabolic status may guide towards underlying problems also predispose to RPL the number losses is related.A retrospective study 123 women with either a history low-order (2-3 losses) or high-order (≥ 4 20 uncomplicated (controls) was performed. Vascular assessed by measuring hemodynamic parameters, determining abnormal parameters analyzing their contribution circulatory...
Objectives To describe the management of primary HIV infection (PHI), focusing on changes in design therapies and time to initiation antiretroviral treatment, clinical outcome, immuno‐virological response over highly active therapy (HAART) its tolerance. Design methods In French PRIMO multicentre cohort, 291 patients presenting with PHI were enrolled between 1996 2001. Data analysed treatment prescription habits a period 5 years, tolerance treatment. Results The proportion who initiated...
Abnormal levels of first trimester placental biomarkers are associated with the development syndrome (PS). However, prediction performance is moderate, possibly explained by clinical heterogeneity PS. Aim this study to investigate association between and presence maternal vascular malperfusion (MVM), as a marker for insufficiency.This retrospective included 195 women available blood sample placenta histological sections examination at Maastricht University Medical Centre. Women were divided...
Dynamic contrast-enhanced MRI (DCE-MRI) can be employed to assess the blood-brain barrier (BBB) integrity. Detection of BBB leakage at lower field strengths (≤3T) is cumbersome as signal noisy, while subtle. Utilizing increased signal-to-noise ratio higher strengths, we explored application 7T DCE-MRI for assessing leakage.A dual-time resolution method was implemented and a slow injection rate (0.3 ml/s) low dose (3 mmol) served obtain changes linearly related gadolinium concentration, that...
Background: Gestational diabetes mellitus (GDM) increases the risk of type 2 and cardiovascular disease (CVD) in women later life. In general population, metabolic syndrome (MetS) shows identical associations. The aim this study was to evaluate association between GDM, constituents MetS pregnancy outcomes. Methods: Of 2041 pregnant undergoing an oral glucose tolerance test (OGTT) 22 30 weeks gestation, data were collected MetS. Odds ratios (ORs) calculated determine associations Results: GDM...