A5008964119- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Palliative Care and End-of-Life Issues
- Healthcare Decision-Making and Restraints
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Aging, Elder Care, and Social Issues
- Connective tissue disorders research
- Patient-Provider Communication in Healthcare
- Geriatric Care and Nursing Homes
- Sleep and Wakefulness Research
- Ethics in medical practice
- Cannabis and Cannabinoid Research
- TGF-β signaling in diseases
- Inflammatory mediators and NSAID effects
- Pain Management and Opioid Use
- Intensive Care Unit Cognitive Disorders
- Opioid Use Disorder Treatment
- Grief, Bereavement, and Mental Health
- Migration, Aging, and Tourism Studies
- Frailty in Older Adults
- Electroconvulsive Therapy Studies
- Telemedicine and Telehealth Implementation
- Urban Green Space and Health
- Memory and Neural Mechanisms
McLean Hospital
2015-2024
Harvard University
2015-2024
Massachusetts General Hospital
2015-2017
Nuffield Orthopaedic Centre
2007-2009
University of Oxford
2006-2009
Zimmer Biomet (United States)
1968
Cornell University
1968
Stanford University
1968
University of Minnesota
1968
Central State Hospital
1968
A compelling genetic association with osteoarthritis (OA) of a functional SNP (rs143383, T/C) in the 5′-UTR GDF5 gene was recently reported case–control cohorts from Japan and China. is pro-chondrogenic growth factor. The T-allele frequency elevated cases, an odds ratio (OR) 1.79, vitro studies demonstrated that this allele mediated moderate but significant reduction activity promoter several cell lines. Our initial objective to assess whether also associated OA broad European population by...
Abstract Objective Single‐nucleotide polymorphism (SNP) rs143383 (T to C) in the 5′‐untranslated region (5′‐UTR) of GDF5 has recently been reported be associated with osteoarthritis (OA) susceptibility, lower expression risk‐associated T allele observed vitro and vivo. The vivo studies were performed on cartilage tissue from OA patients. present study was undertaken expand analysis effect this SNP allelic more joint types, investigate for cis trans factors that interact SNP, examine novel...
Sexual expression can be an important aspect of well being for older adults with dementia living in nursing homes. There is a tension the home, however, between ensuring autonomy residents sexual and protecting from harm. To alleviate this tension, homes conduct assessment residents' capacity consent. This article argues that although such assessments useful initial evaluation capacity, somewhat flawed approach to decision making finding incapacity should not necessarily preclude expression....
Abstract Background Many patients with locally advanced gastro-oesophageal cancers are unable to complete adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy, raising questions about its therapeutic utility. The aim of this study was examine whether pathological response neoadjuvant FLOT can guide use. Methods Patients non-metastatic adenocarcinoma who received underwent surgery from 1 January 2017 2022 43 hospitals across 12 countries were analysed....
Variability in cis-regulation of gene expression has been implicated the phenotypic manifestation complex traits including common, multifactorial diseases. The differential alleles due to polymorphism cis-regulatory elements is common human genome, but there a paucity information about context specificity these control elements. In this study, we examined allelic (DAE) BMP5 mesenchymal tissues obtained from 16 donors undergoing joint replacement for treatment osteoarthritis. We observed...
In a previous study carried out by our group, the genotyping of 36 microsatellite markers from within narrow interval chromosome 6p12.3-q13 generated evidence for linkage and association to female hip osteoarthritis (OA), with most compelling found marker intron 1 bone morphogenetic protein 5 gene (BMP5). this study, we aimed further categorize variants BMP5 OA through an expanded genetic subsequent functional analysis associated polymorphisms. We genotyped 18 common polymorphisms including...
This study began as a single-blind randomized controlled trial (RCT) to investigate the efficacy and safety of electroconvulsive therapy (ECT) for severe treatment-refractory agitation in advanced dementia. The aims are assess reduction using Cohen-Mansfield Agitation Inventory (CMAI), evaluate tolerability outcomes, explore long-term stability global functioning. Due challenges encountered during implementation, including recruitment obstacles operational difficulties, design was modified...
Importance There are limited data on discontinuation rates of antipsychotic medications (APMs) used to treat delirium due acute hospitalization in the routine care older adults. Objective To investigate and patient characteristics APMs following infection-related among US Design, Setting, Participants This retrospective cohort study was conducted using claims (Optum’s deidentified Clinformatics Data Mart database) for January 1, 2004, May 31, 2022. Patients were aged 65 years or without...
Dementia is a common neurodegenerative process that can significantly impair decision-making capacity as the disease progresses. When person found to lack make decision, surrogate decision-maker generally sought aid in decision-making. Typical bases for include substituted judgment standard and best interest standard. Given heterogeneous progressive course of dementia, however, these standards are often insufficient providing guidance with escalating likelihood conflict decisions. In this...
None declared.
Agitation is a common complication of Alzheimer's dementia (Agit-AD) associated with substantial morbidity, high healthcare service utilization, and adverse emotional physical impact on care partners. There are currently no FDA-approved pharmacological treatments for Agit-AD. We present the study design baseline data an ongoing multisite, three-week, double-blind, placebo-controlled, randomized clinical trial dronabinol (synthetic tetrahydrocannabinol [THC]), titrated to dose 10 mg daily, in...
ABSTRACT Objectives: Among older people with cognitive impairment and mild dementia, relatively little is known about the factors that predict preferences for everyday living activities experiences influence relative importance of those experiences. Design: Cross-sectional study. Setting: Participants were recruited from Massachusetts Alzheimer’s Disease Research Center (MADRC) Clinical Core longitudinal cohort. Participants: The sample included 62 community-dwelling adults (Clinical...
Persons with progressive cognitive impairment (CI) increasingly rely on surrogate decision-makers for everyday activities. Yet, little is known about changes in preferences over time or concordance between persons CI and their care partners regarding longitudinal changes.
Osteoarthritis (OA) is the most common musculoskeletal disease in developed countries, and although OA presents a considerable global health burden, widely prescribed treatments such as analgesics total joint replacements are at best palliative. Epidemiological studies have shown that complex, multifactorial disorder with number of risk factors, including environmental genetic components. Progress has been made understanding pathophysiology disease, but molecular mechanisms underlying...
Abstract Background Adults with Alzheimer's disease and related dementias (ADRD) or frailty are susceptible to fractures. Opioid analgesics frequently prescribed after Documenting post‐fracture opioid discontinuation rates predictors of among adults ADRD can inform clinical practice, identify potential disparities, improve pain management guidelines. The objective this paper was investigate in opioid‐naïve older who used opioids an acute fracture. Methods This retrospective cohort study...
Abstract We aimed to determine if the severity of frailty influences duration opioid use following an emergent pain event. This retrospective cohort study included 21,728 fee-for-service Medicare beneficiaries (2013-2018). opioid-naïve individuals aged ≥65 years who initiated opioids within 30 days a hospitalized fracture. Our index date was prescription fill date. excluded those with prior use, chronic pain, or contraindications in preceding year. Frailty defined using claims-based index....
Abstract Background Agitation in Alzheimer’s Disease (Agit‐AD) is a common and troubling neuropsychiatric syndrome which adds significantly to disability caregiver stress. Behavioral interventions lack consistent efficacy there are no FDA‐approved medications. Neurobiological mechanisms that contribute Agit‐AD include brain atrophy, degradation of neurotransmission, neuroinflammation, disrupted circadian rhythms, comorbidities frailty. major source disease progression, patient disability,...