A5042001769- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Advances in Oncology and Radiotherapy
- Blood transfusion and management
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Minimally Invasive Surgical Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Chemokine receptors and signaling
University of Bergen
2011-2025
Haraldsplass Diakonale Sykehus
2013-2023
Deaconess Hospital
2010-2016
Deaconess Hospital
2014
<b><i>Background:</i></b> Complete mesocolic excision (CME) and a high (apical) vascular tie may improve oncologic outcome after surgery for colon cancer. Our primary aim was to emulate previous national result of 73.8% overall survival (OS) with both the open laparoscopic techniques. <b><i>Methods:</i></b> A prospective study radical cancer initiated in Norwegian community teaching hospital 2007 comprised consecutive group 251 patients TNM...
Despite advances in colon cancer research and novel therapies, high risk of recurrence remains a major challenge. This study reports miRNA expression profiling as biomarker for the prognosis TNM stage II III cancer. Fresh frozen biopsies from cohort (N=111) were analyzed by RT-qPCR LASSO regression analysis was used to build classifier miRNAs. The prognostic accuracy tested validated an independent (TCGA-COAD, N=209). identified 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p,...
Abstract Aim Complete mesocolic excision (CME) for colon cancer has been associated with improved oncological outcomes but requires a detailed understanding of complex mesenteric vasculature. Three‐dimensional (3D) reconstructed models derived from patient imaging could enhance preoperative anatomical comprehension, enabling safer, precision CME. Methods In this two‐phase, blinded, crossover study, four expert CME surgeons evaluated vascular anatomy on CT scans and 3D models. phase 1,...
About 20 percent of TNM-stage II colon cancer patients who are treated by surgical resection develop recurrence, and adjuvant chemotherapy in this group is still debated among researchers clinicians. Currently, adverse histopathological clinical factors used to select for following surgery. However, additional biomarkers classify at risk recurrence needed. We have conducted a study using fresh frozen tumor tissue from 54 performed microRNA profiling next-generation sequencing. For the...
A national surveillance program of colon cancer treatment was introduced in 2007. We examined prognostic factors for operated 2000 with an aim improving survival the new and a special focus on merit lymph node yield. cohort 269 patients, 152 women (56.5%), mean age 71 years, at three teaching hospitals followed up 7 years. Overall 5-year 58.0%, overall hospital mortality 5.2%, 4.5% elective cases 12.5% after urgent surgery. In only 41.1% specimens were 12 or more nodes retrieved, but this...
The CXCL12-CXCR4 axis is proposed to mediate metastasis formation. In this study, we examined CXCL12, CXCR4 and the relative expression as prognostic factors in two cohorts of colon cancer patients. Immunohistochemistry (IHC) situ hybridization (ISH) were used study CXCR4, CXCL12 tissue microarrays. Our included totally 596 patients, 290 cohort 1 306 2. For tumour, node, (TNM) stage III, low nuclear was a positive factor for 5-year disease-free survival (DFS) (P = 0.007) 2 0.023)....
<b><i>Background/Aim:</i></b> Laparoscopic complete mesocolic excision (CME) used in the treatment of transverse colon cancer has been questioned on basis technical challenges. The aim this study was to evaluate medium- and long-term clinical survival outcomes after laparoscopic open CME for compare 2 approaches. <b><i>Methods:</i></b> This a retrospective non-randomized patients with prospectively registered data tumour-node-metastasis stages...
Minimally invasive right hemicolectomy (MIRH) is the cornerstone of treatment for patients with right-sided colon cancer. This operation has evolved during recent decades, many innovations and improvements but this also resulted in high variability uptake subsequent substantial variableness. The aim ongoing study to identify current surgical variations, determine most optimal standardised MIRH nationally train implement that technique improve short-term clinical long-term oncological...
Storli K, Lindboe CF, Kristoffersen C, Kleiven Søndenaa K. Lymph node harvest in colon cancer specimens depends on tumour factors, patients and doctors, but foremost specimen handling, APMIS 2010; 119: 127–34. There are good indications that the number of lymph nodes found after resections for somehow has a bearing prognosis. Many factors have been reported literature to influence retrieval. We wanted assess these closer with special focus pathology handling process our own practice. A range...
Background. Pre-operative anaemia has been related to adverse outcomes after surgical management of colorectal cancer. How various factors may contribute and also its post-operative recovery not extensively investigated. Methods. Two hundred thirty five colon cancer patients treated surgically in a community teaching hospital Norway between 2007 2009 were prospectively examined. Results. Anaemia was detected 53.8%, which dependent on tumour location, albumin level female gender. More than...
To (1) develop an assessment tool for laparoscopic complete mesocolic excision (LCME) and (2) report evidence of its content validity.Assessment statements were revealed through semi-structured expert interviews consensus by the Delphi method, both involving panel five LCME surgeons. All experts interviewed then asked to rate describing from 1 (strongly disagree) 5 agree). Responses returned anonymously until was reached. Statements directly included as in if ≥60% responded "agree" or...
Rectal cancer surgery is standardized, resulting in improved survival. Colon has fallen behind and therefore more radical surgical techniques have been introduced. One technique complete mesocolic excision. The aim of this article was to study the complications after introduction standardized excision a single center.Complete introduced 2007, data were collected from 286 patients prior (2007-2010). surgeon decided on open or laparoscopic surgery. Follow-up information recorded until 31...
The number of lymph nodes retrieved from the specimen may be a surrogate measure adequacy extensive colon cancer surgery, but many variables influence total node yield any specimen. We examined which would influential both for negative and positive sampling.The combined results 428 patients three hospitals A to C treated in 2007–2009 with single cancers having R0 segmental resections were analysed. surgical technique pathology staining methods slightly different between hospitals.The mean...
A central lymphadenectomy in right-sided colon cancer involves dissection along the superior mesenteric axis, but extent is debated due to a lack of consensus and fear major complications. This randomized controlled trial compared rate postoperative morbidity patients undergoing laparoscopic versus open colectomy with lymphadenectomy.This open, prospective, operated on (cStages I-III) at two Norwegian institutions between October 2016 December 2021. Dissections were conducted vein group,...
To analyse clinical and long-term oncologic results after laparoscopic complete mesocolic excision (CME) for colonic cancer over a 10-year period.Consecutive patients who received CME at our hospital from 2007 to 2017 were prospectively registered retrospectively analysed. In total, 341 included with tumour-nodal-metastasis (TNM) stages 0-III.The mean age of the was 71.9 years. The median length stay 5 d. lymph node harvest 17.8. mortality rate 1.2%. Fifteen reoperated on anastomotic leaks....
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The complete mesocolic excision competency assessment tool (CMECAT) is a novel designed to assess technical skills in minimally invasive (CME) surgery. aim of this study was construct validity and reliability CMECAT clinical context.Colorectal surgeons were asked submit video recorded laparoscopic CME resections for independent their abilities. videos grouped by surgeons' training level, four established experts recruited as assessors. Extended analysis (G-theory) applied describe assessor...