A5001474297- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Acute Kidney Injury Research
- Inflammatory Bowel Disease
- Urinary Tract Infections Management
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Urinary Bladder and Prostate Research
- Streptococcal Infections and Treatments
- Complement system in diseases
- Advanced Breast Cancer Therapies
- Pneumonia and Respiratory Infections
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Pediatric Urology and Nephrology Studies
- Drug Transport and Resistance Mechanisms
- Neurological Complications and Syndromes
- Cardiovascular Function and Risk Factors
- Peripheral Neuropathies and Disorders
- Nutrition, Genetics, and Disease
- Transplantation: Methods and Outcomes
Odense University Hospital
2013-2024
University of Southern Denmark
2004-2015
Great Ormond Street Hospital for Children NHS Foundation Trust
2013-2014
In-Q-Tel
2013
Hvidovre Hospital
2007-2011
University of Copenhagen
2007
The development of donor-specific HLA antibodies (DSA) is associated with worse renal allograft survival in adult patients. This study assessed the natural history de novo DSA, and its impact on function pediatric transplant recipients (RTR). were measured prospectively using single-antigen-bead assays at 1, 3, 6 12 months posttransplant followed by 12-monthly intervals during episodes dysfunction. Of 215 patients antibody monitoring, 75 (35%) developed DSA median 0.25 years a high...
Abstract Increased focus on the potential negative side effects of steroid usage in pediatric transplantation has led to minimization or steroid‐free transplantation. In this study, we report results after complete avoidance renal period 1994–2009. We evaluate allograft function, BMI , and linear growth. The majority transplanted children were induced with antithymocyte globulin immunosuppressed a calcineurin inhibitor mycophenolate mofetil. Steroids given only when rejection occurred due...
In this prospective study we investigated the role of plasma levels soluble urokinase plasminogen activator receptor (suPAR) in children with urinary tract infection.We measured suPAR during admission 42 suspected acute pyelonephritis and compared results to DMSA scintigraphy.The mean level at was significantly elevated renal involvement (7.3 ng/ml) assessed by scintigraphy without (4.4 ng/ml, P = 0.010). The positive predictive value seems high, since all patients had low values. During...
To study the relationship between CC chemokine receptor CCR5 expression and disease activity in multiple sclerosis (MS) patients treated with beta-interferon (IFN-beta).The Delta32 allele a promoter polymorphism associated cell surface of were analyzed 109 relapsing-remitting MS IFN-beta who followed clinically for 1 year. Cellular was measured by flow cytometry.Patients had higher percentage CCR5-positive monocytes than healthy controls. Increased monocyte correlated weakly an increased...
ABSTRACT Background Kidney transplantation is the best treatment for end‐stage kidney disease but requires immunosuppressive medications, which have significant side effects. Many pediatric recipients experience these effects, leading to dosage reductions, potentially increase risk of alloimmunity. We aimed describe alteration in medication, explore reasons and assess potential impact on Method Data from 49 transplant receiving an allograft 2009 2020 were retrospectively studied. The...
Kidney disease has been reported in adults with inflammatory bowel (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment.In this cross-sectional study we describe extent kidney pathology cohort 56 children IBD. Blood urine samples were analyzed for markers ultrasonography was performed to evaluate pole-to-pole length.We found that 25% patients had either previously ultrasonographic signs chronic disease. The median size compared normal...
ABSTRACT Objectives: The noninvasive Enhanced Liver Fibrosis (ELF) score is used in adults with liver fibrosis as a diagnostic aid. ELF combines 3 serum markers of extracellular matrix remodeling and fibrogenesis: hyaluronic acid (HA), the N‐terminal pro‐peptide collagen type III (PIIINP), tissue inhibitor metalloproteinase‐1 (TIMP‐1). We aimed to evaluate clinical use children. Methods Results: A reference interval for was established using 343 liver‐healthy children ages 6 17 years. median...