A5049395883- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Lipid Membrane Structure and Behavior
- ATP Synthase and ATPases Research
- Axon Guidance and Neuronal Signaling
- Long-Term Effects of COVID-19
- Neurogenesis and neuroplasticity mechanisms
- Migraine and Headache Studies
- SARS-CoV-2 detection and testing
- Nuclear Receptors and Signaling
- Metabolism and Genetic Disorders
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Pancreatic function and diabetes
- HIV-related health complications and treatments
- Phagocytosis and Immune Regulation
- Neuropeptides and Animal Physiology
- Retinal Development and Disorders
- Trigeminal Neuralgia and Treatments
- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Apelin-related biomedical research
University College Dublin
2020-2025
St. Vincent's University Hospital
2023
Fidia Farmaceutici (Italy)
1984-2015
A.P.E. Research (Italy)
2010
University of Parma
2004
Université d'Angers
2001
University of Brescia
1996
Ospedaliero di Castelfranco Veneto
1994-1995
Australian National University
1992
Guy's Hospital
1992
Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions tissue inflammation. In many peripheral tissues, mast interact with the innervating fibers. Changes behaviors of these elements occur after injury/inflammation. As such conditions are typically associated rapid cell activation NGF accumulation inflammatory exudates, we hypothesized that may capable producing NGF. Here report (i) mRNA is expressed adult rat peritoneal cells; (ii)...
Mast cells are multifunctional bone marrow-derived found in mucosal and connective tissues the nervous system, where they play important roles tissue inflammation neuroimmune interactions. Very little is known about endogenous molecules mechanisms capable of modulating mast cell activation. Palmitoylethanolamide, peripheral tissues, has been proposed to behave as a local autacoid downregulating activation inflammation. A cognate N-acylamide, anandamide, ethanolamide arachidonic acid, occurs...
The amino acid L-glutamate is a neurotransmitter that mediates fast neuronal excitation in majority of synapses the central nervous system. Glutamate stimulates both N-methyl-D-aspartate (NMDA) and non-NMDA receptors. While activation NMDA receptors has been implicated variety neurophysiologic processes, excessive receptor stimulation (excitotoxicity) thought to be primarily responsible for injury wide acute neurological disorders including hypoxia-ischemia, seizures, trauma. Very little...
We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant reported by seven European countries. COVID-19 with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0–2.9; B.1.351: 3.6, CI: 2.1–6.2; P.1: 2.6, 1.4–4.8) B.1.1.7/SGTF also intensive care admission 2.3, 1.4–3.5; 2.2, 1.7–2.8).
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
The binding of GM1 ganglioside to crude preparations rat brain neuronal membranes was studied, the following results being obtained: (a) process followed a biphasic kinetics, which displayed break at 0.07-0.08 x 10(-6) M concentration; (b) features concentrations below and, over break, above appeared be different. Below proceeded slowly and brought stable irreversible association molecules membranes. Over much more rapid caused interact in such way that they were releasable by washing could...
The role of gangliosides in neuronal differentiation was studied by addition a mixture bovine brain to cultured neuroblastoma N2A cells. In ganglioside-treated cells the rate and degree neurite formation enhanced. Biochemical correlates indicate that ganglioside-induced morphological is accompanied significant elongation G1phase, decrease 3H-thymidine incorporation into cellular DNA an increase intracellular cAMP content.
The existence and mechanisms of inactivation voltage-gated Ca2+ channels are important, but still debatable, physiological problems.By using the indicators quina fura-2, we demonstrate that in PC12 cells Ca" undergo dependent on both voltage [Caz+Ii.Inactivation, however, is never complete a small number remains open during prolonged depolarization, explaining steady state elevation [Ca2+]i observed depolarized with high KCl.A close parallel exists between channel transient nature...
In order to study the ligand-mediated regulation of NGF receptors in vivo, we assessed receptor mRNA septal area both neonatal and adult rats following intraventricular administration. treatment, comparison with cytochrome c, elicited a pronounced augmentation level mRNA. A similar effect was also observed continuous infusion young rats. addition, this latter case, increase associated an receptor-related immunoreactivity, most likely cholinergic neurons, area. These results show that itself...
This paper analyzes the effects of exogenously supplied GM1 on development, i.e., specific neurotransmitter uptake capability and survival, dopaminergic neurons present in fetal mouse- dissociated mesencephalic cells. Exogenous GM1, but not asialo-GM1, sialic acid, or oligosaccharide chain enhances a time- concentration-dependent manner 3H-dopamine (increase apparent Vmax decrease Km value) long-term survival neurons. The behavior require presence cell-derived neuronotrophic influences...
N ‐acylethanolamines, which include the endocannabinoid anandamide and cannabinoid receptor‐inactive saturated compounds ‐palmitoyl ethanolamine ‐stearoyl ethanolamine, are ethanolamines of long‐chain fatty acids degraded by acid amide hydrolase (FAAH) known to accumulate in degenerating tissues cells. Whilst much evidence supports a protective anti‐inflammatory role both very little information is available with regard bioactivity ethanolamine. Employing murine model passive IgE‐induced...
Abstract The experimental strategy of adding monosialoganglioside GM 1 to a culture medium fetal chick dorsal root ganglia (DRG) was utilized as model system in which examine the potential role modulation neuronal cell responsiveness nerve growth factor (NGF). Data indicate that addition DRG explants or dissociated cells enhances NGF‐induced neurite outgrowth, complexity, and survival following NGF withdrawal. molecule apparently facilitates acquisition maintenance specific properties....
SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of capacity, but whether these predict sufficient capacity variants concern (VOCs), and this is impacted by or infection history remains unclear. Here we analyse individuals recovered from, vaccinated with hybrid immunity SARS-CoV-2. An NT50 ≥ 100 IU confers in trials, however, VOC induce a reduction NT50, use 1000...
Abstract Background Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations linked to systemic inflammation, the relationships between microbiome, inflammation remain unclear. Methods The UPBEAT-CAD sub-study, examining cardiovascular disease (CVD) risk in HIV, enrolled participants matched on status traditional CVD factors. Subclinical was assessed using coronary computed tomography angiography...
Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was measured in slices from hippocampus, cerebral cortex, and corpus striatum at various intervals after transient global ischemia rats. Ischemia induced through the four-vessel occlusion model. [3H]inositol monophosphate formation excitatory amino acids greatly enhanced hippocampal prepared ischemic rats 24 h or 7 days reperfusion. This potentiation more evident using ibotenic acid also observed but not...
<b><i>Background:</i></b> Trace amines, including tyramine, octopamine, and synephrine, are closely related to classic biogenic amines. They have been hypothesized promote migraines other types of primary headaches, but there is no direct evidence supporting this hypothesis. <b><i>Methods:</i></b> Using a multichannel electrochemical high-performance liquid chromatography system, the authors evaluated whether changes in circulating trace amines occur subjects with migraine (with or without...