A5080700624- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Neurotransmitter Receptor Influence on Behavior
- Cholinesterase and Neurodegenerative Diseases
- Cannabis and Cannabinoid Research
- Plant biochemistry and biosynthesis
- Traditional Chinese Medicine Studies
- Nerve injury and regeneration
- Reproductive System and Pregnancy
- Gene Regulatory Network Analysis
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Diet and metabolism studies
- Bioinformatics and Genomic Networks
- Schizophrenia research and treatment
- Nutrition, Genetics, and Disease
- Neuropeptides and Animal Physiology
- Single-cell and spatial transcriptomics
- Bipolar Disorder and Treatment
- Planarian Biology and Electrostimulation
- PARP inhibition in cancer therapy
- Telomeres, Telomerase, and Senescence
- Shoulder Injury and Treatment
University of Maryland, Baltimore
2022
University of Padua
1997-2020
Synlab Czech (Czechia)
2019
DataMED (Italy)
2012
King's College London
2012
Medica (Italy)
2012
Ospedaliero di Castelfranco Veneto
1994-1999
University of Bologna
1998
University of Brescia
1996
Columbia University
1990
Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions tissue inflammation. In many peripheral tissues, mast interact with the innervating fibers. Changes behaviors of these elements occur after injury/inflammation. As such conditions are typically associated rapid cell activation NGF accumulation inflammatory exudates, we hypothesized that may capable producing NGF. Here report (i) mRNA is expressed adult rat peritoneal cells; (ii)...
Mast cells are multifunctional bone marrow-derived found in mucosal and connective tissues the nervous system, where they play important roles tissue inflammation neuroimmune interactions. Very little is known about endogenous molecules mechanisms capable of modulating mast cell activation. Palmitoylethanolamide, peripheral tissues, has been proposed to behave as a local autacoid downregulating activation inflammation. A cognate N-acylamide, anandamide, ethanolamide arachidonic acid, occurs...
The amino acid L-glutamate is a neurotransmitter that mediates fast neuronal excitation in majority of synapses the central nervous system. Glutamate stimulates both N-methyl-D-aspartate (NMDA) and non-NMDA receptors. While activation NMDA receptors has been implicated variety neurophysiologic processes, excessive receptor stimulation (excitotoxicity) thought to be primarily responsible for injury wide acute neurological disorders including hypoxia-ischemia, seizures, trauma. Very little...
Acetylcholinesterase (AChE) inhibitors are one of the most actively investigated classes compounds in search for an effective treatment Alzheimer's disease. This work describes synthesis, AChE inhibitory activity, and structure−activity relationships some related to a recently discovered series inhibitors: ω-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyxanthen-9-ones. The influence structural variations on potency was carefully by modifying different parts parent molecule,...
Nerve growth factor (NGF) is well characterized for its neurotrophic actions on peripheral sensory and sympathetic neurons central cholinergic of the basal forebrain. Recent evidence, however, has shown high levels NGF to be present in a variety biological fluids after inflammatory autoimmune responses, suggesting that mediator immune interactions. Increased serum have been reported both humans experimental animal models psychological physical stress, thus implicating neuroendocrine...
Principal component analysis (PCA) multivariate was applied to study the cytotoxic activity of essential oils from various species Pistacia genus on human tumor cell lines. In particular, obtained P. lentiscus, lentiscus var. chia (mastic gum), terebinthus, vera, and integerrima, screened three adenocarcinoma lines: MCF-7 (breast), 2008 (ovarian), LoVo (colon). The results indicate that all phytocomplexes, with exception mastic gum oil, induce effects one or more PCA highlighted presence...
Tramadol hydrochloride is a centrally acting opioid analgesic, the efficacy and potency of which only five to ten times lower than that morphine. Opioid, as well non‐opioid mechanisms, may participate in analgesic activity tramadol. [ 3 H]‐5‐hydroxytryptamine (5‐HT) uptake rat isolated cortical synaptosomes was studied presence tramadol, desipramine, fluoxetine, methadone Methadone tramadol inhibited synaptosomal H]‐5‐HT with apparent K i s 0.27±0.04 0.76±0.04 μ M , respectively. Morphine...
Background: Dimethyl fumarate (DMF) is a disease-modifying drug for relapsing-remitting multiple sclerosis. Among others, DMF impedes immune activation by shifting the balance between inflammatory and regulatory cell types inducing apoptosis-triggered lymphopenia. Although decrease in lymphocyte count an early effect of several patients, long-term impact on subsets largely unknown. Methods: We performed 2-years observational study total thereof flow cytometry peripheral blood 38 sclerosis...
Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte are usually assayed as diagnostic panels, rather than single biomarkers for specialist clinical use. This retrospective analysis on subpopulations, analyzed over the last few years in an outpatient laboratory Northeast Italy, contributes to establishment of reference values several lymphocytes currently lacking such ranges general...
Vitamin D is a pleiotropic hormone that plays vital role in regulating bone growth, maintaining calcium and phosphate homeostasis, modulating immune function, wide range of other pleiotrophic actions humans, which have increased the attention for its clinical applications. Despite importance, vitamin deficiency prevalent worldwide related to pathophysiological conditions, including an risk osteoporosis chronic autoimmune diseases. The recommended daily doses vary depending on genetics, age,...
Kinesiologic elastic tape is widely used for both clinical and sport applications although its efficacy in enhancing agonistic performance still controversial. Aim of the study was to verify a group healthy basketball players whether neuromuscular taping application (NMT) on ankle knee joints could affect kinematic kinetic parameters jump, either by or inhibiting functional performance. Fourteen male without any ongoing pathologies at upper limbs, lower limbs trunk volunteered study. They...
Changes in protein synthesis are thought to be important the response of neuron axotomy. Certain axonally transported proteins whose increases probably play roles regeneration axon. Although little is known about regulation these changes, cell often controls its production at nuclear level, where transactivating modulate transcription specific genes. Thus, changes might expected among early events following axotomy, but such have not yet been described. We addressed this issue by dissecting...