A5003684009- Antifungal resistance and susceptibility
- Syphilis Diagnosis and Treatment
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive tract infections research
- Infectious Diseases and Mycology
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Central Venous Catheters and Hemodialysis
- HIV Research and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical Analysis and Sensing Techniques
- HIV-related health complications and treatments
- Orthopedic Infections and Treatments
- Streptococcal Infections and Treatments
- Neutropenia and Cancer Infections
- Biochemical effects in animals
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Cystic Fibrosis Research Advances
Mater Misericordiae University Hospital
2006-2024
University College Dublin
2006-2024
Health Service Executive
2020-2024
University of Manchester
2014-2020
Wythenshawe Hospital
2014-2020
Manchester University NHS Foundation Trust
2018-2020
Manchester Academic Health Science Centre
2014-2018
Tufts Medical Center
2013-2014
Trinity College Dublin
2014
St. James's Hospital
2009-2013
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
Factors associated with readmission for patients prescribed outpatient parenteral antibiotic therapy (OPAT) at hospital discharge have not been definitively identified. The study aim was to develop a model of 30-day readmissions OPAT patients.A database comprising 782 treated between 2009 and 2011 single academic center created. Variables collected included patient demographics, comorbidities, infections, classes. Final discrimination assessed using the c-statistic, calibration examined...
Aspartame [SC‐18862; 3‐amino‐H‐(α‐carboxyphenethyl)succinamic acid, methyl ester, the ester of aspartylphenylalanine] is a sweetening agent that organoleptically has about 180 times sweetness sugar. The metabolism aspartame been studied in mice, rats, rabbits, dogs, monkeys, and humans. compound was digested all species same way as are natural constituents diet. Hydrolysis group by intestinal esterases yielded methanol, which oxidized one‐carbon metabolic pool to CO2. resultant dipeptide...
There are a number of different manifestations pulmonary aspergillosis. This study aims to review the radiology, presentation, and histological features lung nodules caused by Aspergillus spp.Patients were identified from cohort attending our specialist Chronic Pulmonary Aspergillosis clinic. Patients with cavitating lesions, or without fibrosis those aspergillomas diagnosis invasive aspergillosis excluded. Demographic, laboratory, clinical data radiologic findings recorded.Thirty-three...
This is, to the best of our knowledge, first case report describe apparent transmission Streptococcus equi subsp. zooepidemicus from an infected dog a handler who subsequently developed severe systemic infection. Characterization haemolytic streptococci isolated both patient and dog, by phenotypic molecular analysis, confirmed canine human isolates were identical.
Healthcare "bundles" have been developed to help providers improve the reliability and delivery of essential healthcare processes. Bundles shown be effective in reducing healthcare-associated infection rates are increasingly used ensure quality patient care. Outpatient parenteral antimicrobial therapy (OPAT) is now standard medical practice treatment a wide variety infections. We review 6 components that we believe comprise an OPAT bundle evidence supporting each: selection, infectious...
A concise invasive candidosis guideline (based on the ESCMID candidaemia guideline) utilizing an informative biomarker [serum β-1-3-d-glucan (BDG)] was developed in 2013 by antifungal stewardship (AFS) team and implemented with help of AFS champion 2014. The main aims programme were to reduce inappropriate use antifungals improve patient outcomes. aim this project evaluate compliance ICU teams impact mortality consumption ICUs (total 71 beds).All patients who prescribed micafungin for...
Background: Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to alafenamide (TAF). We aimed characterize lipids observed after TAF-containing ART a real-world setting. Methods: A prospective study on PLWH enrolled the UCD-ID Cohort who switched ART. Routine laboratory data [including (total cholesterol (TC),...
Background: The use of outpatient parenteral antimicrobial therapy (OPAT) is standard medical practice; however, significant heterogeneity in practice exists. We hypothesized that formal OPAT programs are associated with increased physician participation patient safety activities. Methods: United States Infectious Disease (ID) physicians were contacted and asked to participate an electronic survey from April through June 2012. Data analyzed using SPSS version 20. Results: In all, 3718 316...
To identify the incidence, risk factors and impact on long-term survival of invasive pulmonary aspergillosis (IPA) Aspergillus colonisation in patients receiving vv-extracorporeal membrane oxygenation (ECMO). A retrospective evaluation was performed vv-ECMO at a tertiary hospital Manchester (UK) between January 2012 December 2016. Data collected included epidemiological data, microbiological cultures, radiographic findings outcomes. Cases were classified as proven IPA, putative IPA or...
In February 2025, the first confirmed case of monkeypox virus (MPXV) clade Ia infection outside Africa was identified in a traveller returning to Ireland from Democratic Republic Congo (DRC). We report clinical, laboratory, and epidemiologic features this case, including stable disease course absence secondary transmission. also present phylogenetic analysis APOBEC3-associated mutation profiling that placed obtained patient an evolving cluster MPXV infections Kinshasa, DRC, likely driven by...
In Brief This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples analyzed A2058G mutation, 29 sequenced. 27 (93.1%) had mutation. Azithromycin cannot be recommended treatment Dublin continues have a very high proportion resistant isolates. those who acquired their Ireland.
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...
A large outbreak of syphilis was reported in Dublin, Ireland, 2001. The mean age patients 2001 35 years and 22.5% were HIV-positive. number new cases decreased from 2003 on, however, diagnoses have again increased. All positive serology results 2007-09 identified. Patients included if they had a newly or, the case with previously treated syphilis, four-fold rise rapid plasma reagin titre. Four hundred thirty-nine made. at diagnosis 35.7 (range 17-73 years). twelve (93.8%) occurred men. Three...
Despite inflammation being implicated in cardiovascular disease (CVD) people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify phenotypes 2 independent cohorts PWH. We identified 3 distinct clusters present both that were associated altered...
Background: Chronic pulmonary aspergillosis (CPA) has substantial impact on quality of life. A subset patients develops significant fibrosis, identified either biopsy or radiologically. The term chronic fibrosing (CFPA) been suggested.Methods: We describe 11 with CFPA referred to our centre.Results: Mean age was 58.5 years and five were male. In nine, fibrosis already evident presentation, while in two it developed 3 6 later. predominant radiological feature extensive complete involvement...