A5014642878- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis B Virus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Virology and Viral Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Medical and Biological Ozone Research
- Liver Diseases and Immunity
- Mental Health and Patient Involvement
- Bacillus and Francisella bacterial research
University College Dublin
2020-2025
St. Vincent's University Hospital
2020-2025
University College London
2024
Sapienza University of Rome
2015-2022
University of Milan
2019
University of Turin
2019
Istituto Pasteur
2016
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
Background: Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to alafenamide (TAF). We aimed characterize lipids observed after TAF-containing ART a real-world setting. Methods: A prospective study on PLWH enrolled the UCD-ID Cohort who switched ART. Routine laboratory data [including (total cholesterol (TC),...
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine relationship incident SARS-CoV-2 infection. Methods Adults in a prospective cohort provided blood samples at day 0, 14, 10 months after vaccine. Participants self-reported Plasma anti–SARS-CoV-2 receptor-binding domain (RBD) spike-subunit-1 spike-subunit-2 antibodies...
Increased levels of chemokine interferon-gamma (IFN-γ)-inducible protein-10 (CXCL10), soluble CD163 (sCD163) and CD14 (sCD14) have been reported in HCV infection. The aim this study was to compare, sCD163 sCD14 HCV-infected patients undergoing direct acting antiviral (DAA)-containing regimens with or without interferon (IFN).sCD163, CXCL10 were longitudinally measured by ELISA 159 plasma samples from 25 IFN-based treatment plus telaprevir boceprevir 28 infected subjects treated DAA IFN-free...
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...
Despite inflammation being implicated in cardiovascular disease (CVD) people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify phenotypes 2 independent cohorts PWH. We identified 3 distinct clusters present both that were associated altered...
Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) G (IgG) responses beyond first few weeks after symptom onset remain poorly understood.Within a large, well-phenotyped, diverse, prospective cohort of subjects without severe acute respiratory syndrome 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection historical...
Abstract Introduction Cognitive changes are very frequently reported by people with post‐COVID‐19 syndrome (PCS), but there is limited understanding of the underpinning mechanisms leading to these difficulties. It possible that cognitive difficulties related immune status and/or low mood. The aim present study was examine relationship between and functioning in PCS, while considering whether depression symptoms also influence this association. Methods Participants were recruited an online...
Introduction Research suggests that general practice can play an important role in managing long COVID. However, studies investigating the perspectives of practitioners (GPs) and patients are lacking knowledge regarding optimal COVID care is therefore limited. Aim To investigate GPs’ patients’ on topic its management practice. Methods Brief questionnaires (GP n = 11, Patient 7) in-depth semi-structured interviews 10, were conducted with GPs from Irish practices during July 2022-January 2023....
Background and aims Measles is an infectious disease that represents a serious public health problem worldwide, being associated with increased susceptibility to secondary infections, especially in the respiratory gastrointestinal tracts. The aim of this study was evaluate sCD163 sCD14 levels measles virus (MV) infected patients, as markers immune activation, order better understand their role pathogenesis disease. TNF-α plasma were also evaluated. Methods sCD163, measured by ELISA samples...
Objectives The aims of the study were to describe prevalence obesity in Pharmacokinetic and Clinical Observations People over Fifty (POPPY) cohort, identify demographic, clinical HIV‐specific factors associated with obesity, characterize association between sociodemographic, quality life (QoL). Methods A cross‐sectional analysis was carried out baseline data from three groups [“older” people HIV infection (PWH) aged ≥ 50 years, “younger” PWH < years HIV‐negative controls years] within...
In the direct-acting antiviral (DAA) era, it is important to understand immunological changes after HCV eradication in monoinfected (mHCV) and HIV/HCV coinfected (HIV/HCV) patients. this study, we analyzed sub-populations of monocytes, dendritic cells (DCs), T-lymphocytes inflammatory biomarkers following initiation DAA 15 mHCV 16 patients on effective antiretroviral therapy at baseline sustained virological response 12 weeks (SVR12). Fifteen age- sex-matched healthy donors (HD) were...
Introduction: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for papilloma (HPV) 18 on brushing. Biopsies mucosa led to diagnosis Bowen's disease subsequent pelvic magnetic resonance imaging (MRI) scan evidenced reactive lymphoadenopathies large intra-anal condylomas. The patient was treated complete excision lesion 4 months course supplementation high concentration multistrain probiotic formulation...
Coronavirus disease 2019 (COVID-19) infection, an illness caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide resulting in a global pandemic. A subset of individuals with COVID-19 present pneumonia, evolving some cases to distress syndrome (ARDS), coupled clinical and biochemical features hyperinflammatory syndrome, characterized increased levels ferritin, C-reactive protein (CRP), interleukin (IL)-6 d-dimer.1-3 These phase proteins may reflect...
Myeloid dendritic cells (mDCs) play a complex role in HIV infection regardless of viral replication. The aim our study was to analyse mDCs long term antiretroviral therapy (ART)- suppressed HIV-infected patients. We evaluated the numbers and slanDC context different degree CD4+ T cell recovery, persistent activation (as HLA-DR+/CD3+ expression) monocyte-macrophage assessed terms circulating levels both sCD14 sCD163. enrolled 72 aviremic patients under effective ART 34 healthy donors (HD)....
Abstract Background It is the investigator’s responsibility to communicate relevant information about a clinical trial participants before they provide informed consent take part. Systematic reviews indicate that often have poor understanding of concepts which are key ensuring valid consent, such as randomisation and risks/discomforts. Paper-based participant leaflets forms (PIL/ICFs) becoming longer too complex for many participants. Multimedia interventions enhanced PIL/ICFs been trialled...
Objective: This study investigates the effectiveness and tolerability of switching to a darunavir/cobicistat (DRV/c)-based antiretroviral regimen from ritonavir-boosted protease inhibitor (PI/r)-based in virologically suppressed HIV-positive patients. DRV trough values were also investigated. Setting: Prospective, multicenter, single-country, noninterventional cohort study. Methods: included patients on PI/r-based ART for at least 12 months having plasma HIV-1 RNA <50 copies/mL since 6...
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In past, use IFN-based treatment regimens did not permit an adequate evaluation impact clearance on immune cells, because their antiviral and immunomodulatory properties. The recent development direct-acting (DAA) therapy, which is associated with high rates sustained virological response, enables more accurate analysis immunological modifications following eradication. We studied...