A5024871638- COVID-19 Clinical Research Studies
- Innovations in Medical Education
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Diversity and Career in Medicine
- Reproductive tract infections research
- HIV-related health complications and treatments
- Medical Education and Admissions
- COVID-19 and healthcare impacts
- COVID-19 epidemiological studies
- Clinical Reasoning and Diagnostic Skills
- Liver Disease Diagnosis and Treatment
- Immune responses and vaccinations
- COVID-19 and Mental Health
- Tracheal and airway disorders
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- Viral Infections and Outbreaks Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health and Medical Research Impacts
- Tuberculosis Research and Epidemiology
- HIV/AIDS Impact and Responses
Mater Misericordiae University Hospital
2024-2025
University College Dublin
2022-2025
St. Vincent's University Hospital
2022-2025
Children's Health Ireland at Crumlin
2025
Cork University Hospital
2014-2024
University College Cork
2013-2023
Royal College of Physicians of Ireland
2014-2023
National University of Ireland
2021-2022
APC Microbiome Institute
2021
South Infirmary Victoria University Hospital
2009-2021
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded in which many residents work present a significant challenge learning. purpose of this study was develop national expert group consensus amongst stakeholders PGME to; (i) identify important barriers facilitators CLEs (ii) indicate priority areas for improvement. Our objective provide information focus efforts high CLEs. Group Concept Mapping (GCM) is an...
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated clinical sequelae requires well-coordinated metabolic immune responses that limit viral spread promote recovery of damaged systems. However, the role gut microbiota in regulating these has not been thoroughly investigated. In order to identify mechanisms underpinning interactions with host systems influence disease 2019 (COVID-19) outcomes, we performed a multi-omics analysis on...
Background: The aim of this study was to measure the impact post-acute sequelae COVID-19 (PASC) on quality life, mental health, ability work and return baseline health in an Irish cohort. Methods: We invited individuals with symptoms lasting more than 14 days participate anonymous online questionnaire. Basic demographic data self-reported were recorded. Internationally validated instruments including patient questionnaire somatic, anxiety depressive symptom scales (PHQ-SADS), Patient Health...
<ns3:p>Background The Rapid Evidence Support System Assessment (RESSA) was developed by the Global Commission to evaluate evidence support systems that inform policy decisions. These are designed contextualize existing evidence, guide decision-making, and generate new insights action. As evidence-informed policymaking gains traction globally, it is essential these systems’ effectiveness. In Ireland, Health Research Board, Department of Health, Synthesis Cochrane collaborating conduct a RESSA...
SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of capacity, but whether these predict sufficient capacity variants concern (VOCs), and this is impacted by or infection history remains unclear. Here we analyse individuals recovered from, vaccinated with hybrid immunity SARS-CoV-2. An NT50 ≥ 100 IU confers in trials, however, VOC induce a reduction NT50, use 1000...
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine relationship incident SARS-CoV-2 infection. Methods Adults in a prospective cohort provided blood samples at day 0, 14, 10 months after vaccine. Participants self-reported Plasma anti–SARS-CoV-2 receptor-binding domain (RBD) spike-subunit-1 spike-subunit-2 antibodies...
Context Figured Worlds is a socio-cultural theory drawing on Vygotskian and Bakhtinian traditions, which has been applied in research into the development of identities both learners teachers wider education literature. It now being adopted medical education. Objective The objective this paper to show what can offer Having explained some its central tenets, we apply it an important tension our field. Methods assumption that there uniform 'good doctor' identity, must be inculcated students,...
An improved understanding of the relationship between anatomy learning performance and approaches to can lead development a more tailored approach delivering teaching medical students. This study investigated style preferences, as measured by Visual, Aural, Read/write, Kinesthetic (VARK) inventory questionnaire Honey Mumford's (LSQ), clinical skills assessment at an Irish school. Additionally, mode entry school [undergraduate/direct-entry (DEM) vs. graduate-entry (GEM)], was examined in...
Severe COVID-19 is characterized by hyperimmune host responses contributing to airway damage and acute respiratory distress syndrome. Type III interferons (IFN), including IFN lambda 4 (IFNλ4), expressed in individuals harboring the rs368234815-ΔG allele, are implicated immune viral infections, SARS-CoV-2. We investigated associations between IFNλ4 expression through genotyping disease severity 853 laboratory-confirmed SARS-CoV-2 cases enrolled All-Ireland Infectious Diseases Cohort....
Abstract Higher circulating SARS-CoV-2 IgG titers correlate with ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 negative, confirmed close contacts. Receptor-binding domain (RBD) and full-spike memory B-cell frequencies were measured at exposure, participants serially tested for incident infection over 14 days. Those who developed had significantly lower RBD titers, not...
Muscle protein wasting occurs in human immunodeficiency virus (HIV)-infected individuals and is often the initial indication of acquired syndrome (AIDS). Little known about alterations muscle metabolism that occur with HIV infection. Nine subjects AIDS (CD4 < 200/mm 3 ), chronic stable opportunistic infections (OI), ≥10% weight loss, fourteen HIV-infected men one woman > ) without or OI (asymptomatic), six HIV-seronegative lean (control) received a constant intravenous infusion [1- 13...
Biologics have revolutionized the treatment of moderate-to-severe psoriasis, but serious infection is a risk with these immunosuppressive agents.1 An increased tuberculosis (TB) reactivation in patients latent TB well recognized anti–tumor necrosis factor (TNF)-α agents, as TNF has central role immunity, and anti–TNF-α agents interfere innate cell-mediated immune responses.2 Testing for treating before starting therapy reduces on biologic agents.
ABSTRACT Purpose Workplace-based assessments (WBAs) were originally intended to inform learning and development by structuring effective observation-based feedback. The success of this innovation has not yet been established due in part the widely varied tools, implementation strategies research approaches. Using a conceptual framework experience, trajectories reifications workplace learning, we aimed explore trainer trainee experiences perceptions value WBAs. Study design Trainers trainees...
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...