A5081028480- COVID-19 Clinical Research Studies
- Poisoning and overdose treatments
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Global Cancer Incidence and Screening
- Heavy Metal Exposure and Toxicity
- Colorectal Cancer Screening and Detection
- Intensive Care Unit Cognitive Disorders
- Plant-based Medicinal Research
- Restraint-Related Deaths
- Carcinogens and Genotoxicity Assessment
- Medical and Biological Sciences
- Sepsis Diagnosis and Treatment
- Health, Medicine and Society
- COVID-19 and Mental Health
- Immunotoxicology and immune responses
- Cutaneous Melanoma Detection and Management
- Medical Malpractice and Liability Issues
- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Sedative Agents
- Cancer Diagnosis and Treatment
- Pesticide Exposure and Toxicity
- Economic and Financial Impacts of Cancer
- Drug-Induced Hepatotoxicity and Protection
- interferon and immune responses
London School of Hygiene & Tropical Medicine
2024
Cwm Taf University Health Board
2023-2024
University of London
2024
Royal Glamorgan Hospital
2021-2023
Prince Charles Hospital
2023
NIHR Leicester Biomedical Research Centre
2023
University of Leicester
2023
Glenfield Hospital
2023
South Infirmary Victoria University Hospital
2014-2023
University of Oxford
2023
Abstract BACKGROUND Description of the epidemiology noncutaneous melanoma has been hampered by its rarity. The current report was largest in‐depth descriptive analysis incidence in United States, using data from North American Association Central Cancer Registries. METHODS Pooled 27 states and one metropolitan area were used to examine anatomic subsite, gender, age, race, geography (northern/southern coastal/noncoastal) for cases diagnosed between 1996 2000. Percent distribution stage...
Previous studies found that uninsured and Medicaid insured cancer patients have poorer outcomes than with private insurance. We examined the association between health insurance status survival of New Jersey 18-64 diagnosed seven common cancers during 1999-2004. Hazard ratios (HRs) 95% confidence intervals for 5-year cause-specific were calculated from Cox proportional hazards regression models; was primary predictor adjustment other significant factors in univariate chi-square or...
In vivo transfection of established tumors with immunostimulatory genes can elicit antitumor immunity. Therefore, we evaluated the safety and efficacy intratumoral injections a bacterial superantigen cytokine gene in dogs malignant melanoma, spontaneous highly canine tumor. 26 melanoma were treated lipid-complexed plasmid DNA encoding staphylococcal enterotoxin B either GM-CSF or IL-2. Dogs for treatment-associated toxicity, tumor responses, immunologic survival times. The overall response...
We investigated racial/ethnic and socioeconomic disparities in cancer survival assessed if racial can be explained by status (SES) using New Jersey State Cancer Registry data. included cases diagnosed during 1986–1999 (n=471,939). Hazard ratios were calculated for all cancers combined female breast, colorectal, lung, prostate race/ethnicity SES 1993–1999. Survival rates compared diagnosis years 1986–1992 observed worse Black patients a gradient the risk of death after adjusting age stage at...
Abstract Millennials (ages 18‐35) are now the largest living generation in US, making it important to understand and characterize rising trend of colorectal cancer incidence this population, as well other younger generations Americans. Data from New Jersey State Cancer Registry (n = 181 909) Surveillance, Epidemiology, End Results program 448 714) were used analyze invasive CRC trends 1979 2014. Age, sex, race, ethnicity, subsite, stage differences between adults (20‐49) screening age (≥50)...
A spatial scan statistic was used to search for geographic areas with significantly elevated proportions of women diagnosed distant stage breast cancer in New Jersey 1995-1997. The identified then were mapped and characterized using data from the 1990 U.S. Census locations mammography facilities. These areas' population characteristics included relatively high black or Hispanic linguistically isolated households. Targeted education screening programs this information may increase diagnosis...
Biologics have revolutionized the treatment of moderate-to-severe psoriasis, but serious infection is a risk with these immunosuppressive agents.1 An increased tuberculosis (TB) reactivation in patients latent TB well recognized anti–tumor necrosis factor (TNF)-α agents, as TNF has central role immunity, and anti–TNF-α agents interfere innate cell-mediated immune responses.2 Testing for treating before starting therapy reduces on biologic agents.
The study's purpose was to investigate thyroid cancer incidence time trends, birth cohort effects, and association with socioeconomic status (SES) in New Jersey (NJ), a high state, using NJ State Cancer Registry data. Thyroid rates each sex, nearly all age groups, two major histologies stages significantly increased between 1979 2006. For age-specific began greatly increasing the 1924 and, generally, highest rate for five-year group occurred latest diagnosis period. were higher Census tracts...
Despite improvements in early detection of breast cancer, disparities persist stage at diagnosis, which is an important prognostic factor.We used the space-time scan statistic SaTScan to identify geographic areas and time periods with significantly elevated proportions female cancer diagnosed situ or distant New Jersey. The analyses were conducted census tracts as unit analysis, elliptical spatial windows, 3-year temporal Poisson models. Statistical significance was determined by 999 Monte...
Although invasive cervical cancer incidence has declined, disparities persist. We identified spatial clusters of census tracts with elevated rates using New Jersey State Cancer Registry cases 20 years or older diagnosed in 2005–2009. Each cluster’s population was compared the rest Jersey’s on demographic and socioeconomic characteristics. Odds ratios that assessed associations between statistically significant characteristics (from a univariate comparison versus Jersey) being case cluster...
Management of pyoderma gangrenosum in established malignancy is challenging. When vital structures are at risk from ulceration, aggressive management required; however, immunosuppressive therapy may compromise the prognosis for an underlying malignancy. The optimal this setting unclear. We report on a 64-year-old woman with follicular lymphoma partial remission, who had severe genital gangrenosum. After multidisciplinary evaluation, she was treated corticosteroids and cyclosporine healed...
As the sequencing of human genome proceeds, need for a new screen in vivo function is becoming apparent. Many investigators are turning to various transgenic models as means studying function. However, these approaches very time consuming, with transgene-expressing mouse model often taking months establish. We have developed an efficient system delivering genes vivo, which allows gene product be studied early 24 h after introduction into model. The delivery employs novel cationic lipid,...