A5028326433- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Lipoproteins and Cardiovascular Health
- Orthopedic Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes and associated disorders
- Infective Endocarditis Diagnosis and Management
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- Tuberculosis Research and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Non-Invasive Vital Sign Monitoring
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- Muscle and Compartmental Disorders
University College Dublin
2015-2025
St. Vincent's University Hospital
2016-2025
Mater Misericordiae University Hospital
2006-2024
Saint Vincent's Catholic Medical Center
2020
National University of Ireland
2020
Office of Infectious Diseases
2020
Massachusetts General Hospital
2014-2018
Harvard University
2014-2018
University Hospital Galway
2017
University Hospital Limerick
2017
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV) infection has led to marked improvement in life-expectancy those infected with HIV. Despite reductions the incidence of AIDS effective treatment, patients continue experience considerable morbidity and mortality from non-AIDS illness such as premature cardiovascular disease, liver failure renal failure. These morbidities, particularly are thought be related a combination effects an ageing...
Fibrosis is a predominant feature of IgG4-related disease (IgG4-RD). B-cell depletion induces prompt clinical and immunological response in patients with IgG4-RD, but the effects this intervention on fibrosis IgG4-RD are unknown. We used enhanced liver (ELF) score to address impact rituximab fibroblast activation. The ELF an algorithm based serum concentrations procollagen-III aminoterminal propeptide, tissue inhibitor matrix metalloproteinase-1 hyaluronic acid.Ten active, untreated were...
Current or recent use of abacavir for treating human immunodeficiency virus type 1 (HIV-1) infection has been associated with increased rates myocardial infarction (MI). Given the role platelet aggregation in thrombus formation MI and reversible nature association, we hypothesized that patients treated would have reactivity.In a prospective study adult HIV-infected patients, determined associations between antiretrovirals (ARVs), particular nucleoside reverse transcriptase inhibitor...
Objectives Monocyte activation, endothelial dysfunction and platelet activation all potentially contribute to the increased risk of cardiovascular disease ( CVD ) reported in those with HIV ‐1 infection. To date, no study has examined how initiation antiretroviral therapy ART affects markers three processes. We aimed compare monocyte, function between untreated ‐positive subjects ‐negative controls examine early effects on these markers. Methods measured monocyte [soluble CD14 sCD14 sCD163...
The immuno-pathogenic mechanisms of chronic hepatitis C virus (HCV) infection remain to be elucidated and pose a major hurdle in treating or preventing HCV-induced advanced liver diseases such as cirrhosis. Macrophages are component the inflammatory milieu disease, generally derived from circulating monocytes; however very little is known about their role diseases. To investigate activation macrophages fibrosis, we utilized recently developed humanized mouse model with autologous human...
Oritavancin is a novel lipoglycopeptide with activity against Gram-positive organisms including streptococci, methicillin-resistant Staphylococcus aureus, vancomycin-resistant S aureus (VRSA), and enterococci (VRE) [1-3]. The US Food Drug Administration approved oritavancin as single intravenous dose of 1200 mg for the treatment acute bacterial skin structure infections on basis 2 clinical trials demonstrating noninferiority compared vancomycin [4, 5]. There are limited options serious VRE...
Background: Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to alafenamide (TAF). We aimed characterize lipids observed after TAF-containing ART a real-world setting. Methods: A prospective study on PLWH enrolled the UCD-ID Cohort who switched ART. Routine laboratory data [including (total cholesterol (TC),...
SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of capacity, but whether these predict sufficient capacity variants concern (VOCs), and this is impacted by or infection history remains unclear. Here we analyse individuals recovered from, vaccinated with hybrid immunity SARS-CoV-2. An NT50 ≥ 100 IU confers in trials, however, VOC induce a reduction NT50, use 1000...
Soluble CD163 (sCD163), a marker of Kupffer cell activation detectable in serum, correlates with inflammation and fibrosis chronic viral hepatitis, but its role nonalcoholic fatty liver disease is unknown. We hypothesized that sCD163 would correlate activity fibrosis.Liver biopsies serum were obtained from 145 obese subjects undergoing gastric bypass surgery. Subjects divided into four groups based on stage score (NAS); Group 1: F0, NAS=0; 2: F<2, 0<NAS<5; 3: NAS≥5, F<3; or 4: F≥3, any NAS....
Coinfection with human immunodeficiency virus (HIV) accelerates hepatitis C (HCV)-related liver fibrosis. Macrophages are triggered during both viral infections and critical in inflammation/fibrogenesis. Liver fibrosis strongly associates serum soluble CD163 (sCD163, a macrophage activation marker); comprehensive evaluation HIV/HCV coinfection is lacking.
Introduction Severe COVID-19 is characterized by hyperimmune host responses contributing to airway damage and acute respiratory distress syndrome. Type III interferons (IFN), including IFN lambda 4 (IFNλ4), expressed in individuals harboring the rs368234815-ΔG allele, are implicated immune viral infections, SARS-CoV-2. Methods We investigated associations between IFNλ4 expression through genotyping disease severity 853 laboratory-confirmed SARS-CoV-2 cases enrolled All-Ireland Infectious...
Human immunodeficiency virus (HIV) infection is associated with increased cardiovascular risk and reduced high-density lipoprotein cholesterol (HDL-c). In vitro, HIV impairs monocyte-macrophage efflux, a major determinant of circulating HDL-c, by increasing ABCA1 degradation, compensatory upregulation messenger RNA (mRNA).We examined expression genes involved in uptake, metabolism, efflux monocytes from 22 HIV-positive subjects on antiretroviral therapy (ART-Treated), 30 untreated...
Background Dysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought underlie the progression of disease 2019 (COVID-19) disease. We sought determine whether early host immune-related gene expression could predict clinical Methods analysed 579 immunological genes in peripheral blood mononuclear cells taken after symptom onset using NanoString nCounter and compared SARS-CoV-2 negative controls with positive subjects mild (SARS+ Mild)...
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine relationship incident SARS-CoV-2 infection. Methods Adults in a prospective cohort provided blood samples at day 0, 14, 10 months after vaccine. Participants self-reported Plasma anti–SARS-CoV-2 receptor-binding domain (RBD) spike-subunit-1 spike-subunit-2 antibodies...
Abstract Background Whole-genome sequencing (WGS) of SARS-CoV-2 laboratory-confirmed cases can provide insights into viral transmission and genetic diversity at a population level. However, less is known about the impact non-pharmaceutical interventions (NPIs), including ‘lockdowns’, on circulating lineages variants concern, relative contribution travel to re-emergence pandemic waves within communities or how different contribute disease severity. Methods We have conducted an analysis...
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...