A5027230201- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Kawasaki Disease and Coronary Complications
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Viral gastroenteritis research and epidemiology
- Neonatal and Maternal Infections
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- HIV-related health complications and treatments
- Cardiovascular Issues in Pregnancy
- Influenza Virus Research Studies
- HIV Research and Treatment
- Inflammasome and immune disorders
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Vector-borne infectious diseases
- Antibiotic Resistance in Bacteria
- Virology and Viral Diseases
St. Vincent's University Hospital
2023-2024
University College Dublin
2016-2024
Children's Health Ireland at Crumlin
2008-2023
AstraZeneca (United States)
2023
Rotunda Hospital
2021
Temple Street Children's University Hospital
2010-2019
Our Lady's Hospital
2008-2019
Royal College of Surgeons in Ireland
2017
National Children’s Research Centre
2015
Wexford General Hospital
2015
BackgroundActivated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding catalytic subunit of (PI3Kδ).ObjectiveWe sought to review clinical, immunologic, histopathologic, and radiologic features APDS large genetically defined international cohort.MethodsWe applied clinical questionnaire performed medical notes, radiology, histopathology, laboratory investigations 53 patients with...
Human IFNAR2 deficiency causes fatal susceptibility to live viral vaccines.
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
Objective. In 2002, the Chicago Department of Public Health (CDPH; Chicago, Illinois) convened Chicago-Area Neonatal MRSA Working Group (CANMWG) to discuss and compare approaches aimed at control methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units (NICUs). To better understand these issues on a regional level, CDPH Evanston Human Services (EDHHS; Evanston, began an investigation. Design. Survey collect demographic, clinical, microbiologic, epidemiologic data...
Objective— Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD when compared with nonaneurysmal arteries from control children. Methods Results— MMP-2, MMP-9, tissue inhibitor metalloproteinase (TIMP)-1, TIMP-2 were immunolocalized coronary children fatal controls. In aneurysms, MMP-2 was prominent thickened...
Attention has focused on the possibility of cure for HIV infected infants if treated promptly after delivery. The "Mississippi baby," who had very prolonged remission antiretroviral discontinuation, may represent a unique situation. We report an infant from birth, seroreverted, remained virologically suppressed, and undetectable HIV-1 RNA DNA at 4 years age, yet experienced virologic rebound within days discontinuation therapy.
Faced with expectations to improve patient safety and contain costs, the US health care system is under increasing pressure comprehensively objectively account for nosocomial infections. Widely accepted infection surveillance methods, however, are limited in scope, not sensitive, applied inconsistently.
We assessed infections caused by extended-spectrum-beta-lactamase-producing Escherichia coli or Klebsiella spp. treated with piperacillin-tazobactam to determine if the susceptibility breakpoint predicts outcome. Treatment was successful in 10 of 11 nonurinary from susceptible strains and 2 6 MICs >16/4 mug/ml. All six urinary responded treatment regardless susceptibility.
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...
Abstract MIS-C is a systemic inflammation disorder with poorly characterised immunopathological mechanisms. We compared changes in the immune response children (n = 12, 5–13 years) to healthy controls 14, 5–15 years). Analysis was done whole blood treated LPS. Expression of CD11b and Toll-like receptor-4 (TLR4) neutrophils monocytes were analysed by flow cytometry. Serum cytokines (IL-1β, IL-2, IL-6, IL-8, IL-10, IL-Ira, TNF-α, TNF-β, IFN-Υ, VEGF, EPO GM-CSF) mRNA levels inflammasome...
ABSTRACT During an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in the neonatal intensive care units at two hospitals, we assessed several sites for detection MRSA colonization. Nasal cultures found 32 33 MRSA-colonized patients (97%). Rectal detected 29% 24 identified by paired rectal and nasal samples axillary 22% 9 with swabs. There were no positive umbilical samples.
ABSTRACT Shiga toxin-producing Escherichia coli bacteria (STEC) are emerging pathogens capable of producing sporadic and epidemic diarrhea, hemorrhagic colitis, potentially life-threatening hemolytic-uremic syndrome. Although the presence E. O157 can be readily detected in stool by sorbitol-MacConkey agar culture (SMAC), STEC non-O157 serotypes cannot. In contrast to culture, testing for toxins 1 2 detects both causing disease. Over two consecutive summers, we evaluated performance ProSpecT...
In several countries, respiratory syncytial virus prophylaxis is offered to late preterm infants who are at escalated risk of hospitalization (RSVH). However, targeted should be informed by country-specific data. This study, which uniquely includes 36 weeks gestational age (GA) infants, aims establish the factors for RSVH in 32-36 GA Ireland.A prospective observational study 13 hospitals laboratory-confirmed nonprophylaxed was conducted from July 2011 February 2014. Baseline and first-year...
Despite inflammation being implicated in cardiovascular disease (CVD) people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify phenotypes 2 independent cohorts PWH. We identified 3 distinct clusters present both that were associated altered...
In resource-rich settings, universal adoption of a 4- rather than 6-week neonatal antiretroviral (ARV) prophylaxis regimen could reduce toxicity and results in cost savings, provided prevention mother-to-child transmission program effectiveness is not compromised.Between January 1999 December 2008, 10-year study the observational database Irish that uses ARV was undertaken. Maternal infant data were analyzed to determine vertical rate (VTR) outcome. Infants categorized as uninfected if, off...