A5026459940- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and Maternal Infections
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Autopsy Techniques and Outcomes
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Airway Management and Intubation Techniques
- Neonatal and fetal brain pathology
- Inflammasome and immune disorders
- Emergency and Acute Care Studies
- Preterm Birth and Chorioamnionitis
- Kawasaki Disease and Coronary Complications
- Heme Oxygenase-1 and Carbon Monoxide
- Appendicitis Diagnosis and Management
- Innovations in Medical Education
- Diabetes and associated disorders
- Linguistic research and analysis
- Congenital Diaphragmatic Hernia Studies
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastroesophageal reflux and treatments
Children's Health Ireland at Crumlin
2017-2024
Trinity College Dublin
2018-2024
Auckland City Hospital
2023
University of Edinburgh
2023
Tallaght University Hospital
2018-2020
Hartford Financial Services (United States)
2019
Trinity Health
2019
National Maternity Hospital
2014-2019
Our Lady's Hospital
2015-2017
Abstract Background Paediatric traumatic brain injury (TBI) is recognised to have significant longer-term neurocognitive effects. Childhood a time of high risk for head injury. Functional recovery variable with combination any or all physical, cognitive and emotional impairment. Immune activation alteration in cytokine levels are present following TBI which may differ from adults. Methods Pro- anti-inflammatory cytokines including Interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, IL-17A, Tumor...
Abstract MIS-C is a systemic inflammation disorder with poorly characterised immunopathological mechanisms. We compared changes in the immune response children (n = 12, 5–13 years) to healthy controls 14, 5–15 years). Analysis was done whole blood treated LPS. Expression of CD11b and Toll-like receptor-4 (TLR4) neutrophils monocytes were analysed by flow cytometry. Serum cytokines (IL-1β, IL-2, IL-6, IL-8, IL-10, IL-Ira, TNF-α, TNF-β, IFN-Υ, VEGF, EPO GM-CSF) mRNA levels inflammasome...
We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, cerebral palsy age-matched controls. Using flow cytometry, we demonstrate alterations circulating T, B natural killer cell numbers. Invariant T Vδ2+ γδ numbers frequencies were strikingly higher NE, post-NE compared to controls, whereas mucosal-associated invariant cells Vδ1 depleted from palsy. Upon stimulation ex vivo, cells, Vδ2 NE more readily produced...
Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram-positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist which attenuates cytokine production improves outcomes sepsis. We hypothesised that signalling may be abnormal children DS contribute their clinical phenotype....
Abstract Aim Histological chorioamnionitis (HCA) is associated with preterm birth and adverse neonatal outcomes. We evaluated the rise in C‐reactive protein (CRP) infants as a predictor of HCA severity Methods Consecutive infants, born January 2009 to 2014 National Maternity Hospital, Dublin, under 32 weeks' gestation or <1.5 kg birthweight, were included. was staged maternal inflammatory response, foetal response non‐HCA. Results Preterm (n = 518) included mean gestational age 28.5 ± 2.8...
Glial fibrillary acidic protein (GFAP) is a neuronal released after traumatic brain injury (TBI) and detectable in serum samples. GFAP correlates with symptom severity adults may be marker of children milder symptoms or preverbal children.GFAP was examined severe TBI (initial Glasgow Coma Scale score <8), mild (Glasgow 14/15), at 0 to 4 10 14 days compared healthy age-matched controls. Mechanism, time points from injury, were recorded.The study enrolled 208 including 110 (n = 104 mild, 6...
### Learning Point for Clinicians Female reproductive tract tuberculosis is rare in the developed world and its diagnosis challenging. However, this case illustrates importance of including female differential any gynaecological complaint healthcare workers, due to high mortality associated with vertical transmission. A 4-month-old Caucasian girl presented a cyanotic episode requiring immediate intubation, following 2 weeks history cough fever failure-to-thrive since birth. She was born...
Abstract Introduction : Systemic Inflammation is associated with Traumatic Brain Injury (TBI) and therefore a potential target for immunomodulation. Dysregulated immune function post-TBI increased susceptibility to infection post-concussive syndrome. The inflammasome protein complex an amplified proinflammatory response immunomodulation that preserves antimicrobial immunity. Methods Samples from children mild TBI (mTBI; Glasgow coma scale (GCS) 14/15), severe (sTBI; GCS < 8) control were...
The immune system is inexperienced before birth and tends to be tolerogenic, rather than immunogenic. After birth, the adaptive develops while facing microbial challenges, but it can become impaired as old age progresses persistent inflammation lead chronic morbidity, disability frailty. To investigate potential contributions of lymphocyte subsets immunity from until age, we enumerated circulating innate conventional lymphocytes measured serum cytokine levels in 10 cord blood samples...
<h3>Aims</h3> To evaluate systemic inflammation in TBI by exploration of the inflammasome pathway, a component innate immune system that regulates and induces inflammation. We examine pathway at baseline compared with healthy control children, vitro response to both LPS stimulation melatonin therapy. Melatonin has protective effects against NLRP3 activation therapeutic implications. <h3>Methods</h3> Whole blood was sampled from children (n=10) within 24 hours injury age-matched controls...
Objective To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on validated Gorelick Scales. Design, setting patients Prospective unblinded study from April 2016 to February 2017 in a paediatric emergency department. Patients aged 1 month 5 years, with vomiting and/or diarrhoea decreased intake signs of moderate or severe clinical concern for hypoglycaemia were eligible. Main outcome measures The primary was describe POC...
<h3>Background</h3> Early infant CRP levels in the setting of Chorioamnionitis (CA) have not been fully defined as a predictor cognitive, behavioural, and neuro-developmental outcomes among extremely preterm neonates. <h3>Methods</h3> 499 neonates had Placental pathology, level Vermont Oxford recorded. Death developmental at 2 yrs were examined for 247 infants <32 wks <1.5 kg. Multivariable logistic linear regression models developed to assess association between CA controlling...
<h3>Background</h3> Chorioamnionitis (CA) is associated with preterm birth and adverse neonatal outcomes. The correlation between stage of histological CA, haematological parameters in the early postnatal period are incompletely defined. <h3>Aim</h3> To examine relationship CRP grade CA VLBW infants any associations <h3>Methods</h3> A retrospective review consecutive born <32 weeks gestation or <1.5 kg at a single centre tertiary referral centre. on placental histology was reported as...
<h3>Introduction</h3> There is a paucity of information about the light and heat output laryngoscopy equipment. We became concerned potential laryngoscope blade burn following an episode during intubation mounted <i>in-vitro</i> study larynoscopes to determine temperatures reached clinical use. <h3>Methods</h3> The temperature incandescent bulb from ten different laryngoscopes was measured using Real Time controller National Instruments for data logging into PC. A second set tests were...
<h3>Aims</h3> The role of point-of-care (POC) ketones in relation to acute dehydration with ketosis the paediatric emergency department (PED) has yet be established. Previous studies highlight that clinical symptoms and tests are inexact discerning degree predicting course PED. aim this study was establish relationship between triage POC as per validated Gorelick Score Secondary outcomes were patient disposition initial ketone levels rate change response treatment. <h3>Methods</h3> A...
<h3>Aims</h3> To determine the burden and aetiology of traumatic brain injuries (TBIs) presenting to tertiary paediatric emergency departments (PEDs). number TBIs that are symptomatic, requiring imaging, re-presenting admission. <h3>Methods</h3> Retrospective analysis presentations children 0–16 y 3 Paediatric Emergency Departments (PEDs) in a large urban area for 24 months. Diagnoses head injury, intracranial bleed, skull fracture those re-attending with same complaint within 28 days were...
<h3>Background</h3> Toll like receptors (TLRs) are key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist shown reduce cytokine production improve outcomes sepsis. We hypothesized that signalling may be anomalous children DS contribute their clinical...
<h3>Background</h3> Mild Traumatic Brain Injury (mTBI) is a common childhood occurrence with more severe phenotype in adolescence. Systemic inflammation has been demonstrated to be integral the pathogenesis of ongoing symptoms. The inflammasome component innate immunity that involved regulating and inducing response cell damage may have modifiable role mTBI. <h3>Objective</h3> We pathway activation hypothesized pubertal development modulates activation. correlated scores gene transcription....