A5014633037- Down syndrome and intellectual disability research
- Immunodeficiency and Autoimmune Disorders
- Cystic Fibrosis Research Advances
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Chronic Disease Management Strategies
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Circadian rhythm and melatonin
- Frailty in Older Adults
- Kawasaki Disease and Coronary Complications
- Human Health and Disease
- Trauma and Emergency Care Studies
- Tracheal and airway disorders
- Biotin and Related Studies
- Metabolism and Genetic Disorders
- Pediatric health and respiratory diseases
- Mitochondrial Function and Pathology
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Medical Coding and Health Information
- Respiratory Support and Mechanisms
- Health and Medical Studies
- Adolescent and Pediatric Healthcare
Tallaght University Hospital
2018-2022
Trinity College Dublin
2018-2022
Children's Health Ireland at Crumlin
2020
Temple Street Children's University Hospital
2017
University College Dublin
2017
Scientific Center of Children's Health
2012
Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function altered in DS therefore we examined responses CD11b Toll like receptor 4 (TLR-4), which are important cell surface markers upregulated response to Lipopolysaccharide (LPS) endotoxin, immunomodulator melatonin. Neutrophil monocyte LPS melatonin children who were clinically stable compared age-matched controls. Whole blood was...
Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram-positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist which attenuates cytokine production improves outcomes sepsis. We hypothesised that signalling may be abnormal children DS contribute their clinical phenotype....
Abstract Background Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has myriad of functions, we hypothesised that this therapeutic agent could modulate the innate system in cohort. Methods We investigated neutrophil monocyte function (CD11b, TLR4 expression flow cytometry), genes involved TLR signalling (MyD88,...
The implementation of the multidisciplinary Down Syndrome Health Surveillance clinic at Children's Ireland Tallaght, Dublin has shown significant improvements in adherence to guidelines as well providing health promotion strategies such information on immunisations. Our project provides a framework which would be potentially emulated and used other medical conditions. reduction attendances co-ordination same-day appointments improved parental satisfaction quality care.
A mother of a 7-year-old boy with autism spectrum disorder (ASD) attends the developmental clinic. She is very concerned as her child has significant behavioural problems associated autism. done some research into alternative therapies. asks for your opinion on chelating therapy. In children ASD (patient) does pharmacological chelation therapy (intervention) improve behaviour (outcome)? Secondary sources: The Cochrane Library was searched in January 2018 terms and Chelation. One systemic...
A 15-year-old girl, with an 8-year history of well-controlled focal epilepsy, moderate intellectual disability, and neuropsychiatric problems (aggression disinhibition), presented continuous semirhythmic repetitive movement the left hand (video at [Neurology.org][1]). EEG showed new-onset nonrhythmic/nonperiodic central spike-wave not time-locked to abnormal movements (figure, A). MRI brain demonstrated subtle cortical T2–fluid-attenuated inversion recovery hyperintensity in right precentral...
<h3>Introduction</h3> Trisomy 21, also known as Down syndrome (DS), is a clinical disorder where third copy of chromosome 21 present. Approximately 95% DS are due to meiotic nondisjunction, with the remaining 5% caused by chromosomal translocation or mosaicism. Children predisposed recurrent respiratory infections number anatomical and immunological features. Our project investigated whether there evidence supporting refuting use antibiotic prophylaxis for in population. <h3>Methods</h3> A...
<h3>Aims</h3> Down Syndrome (DS) is the most common genetic syndrome associated with abnormal immune function and defects. There an increased susceptibility to both bacterial viral infections. We aimed examine degree of immunodeficiencies in children DS. <h3>Methods</h3> Children who attended specialist multidisciplinary DS clinic Tallaght were included, medical details collected especially relation infections, recurrent respiratory tract infections (RTIs), hospital admissions vaccinations....
<h3>Background</h3> Toll like receptors (TLRs) are key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist shown reduce cytokine production improve outcomes sepsis. We hypothesized that signalling may be anomalous children DS contribute their clinical...
<h3>The problem</h3> Down syndrome (DS) is the most prevalent chromosomal abnormality accounting for 8% of all registered cases in Europe. One baby with DS born out every 444 live births Ireland. Recent decades have seen a substantial increase life expectancy children DS. The implementation medical guidelines preventative health care programmes to helped improve and quality life. <h3>Aim</h3> development multidisciplinary one stop clinic provide surveillance Syndrome adherence outlined by...
<h3>Background</h3> The Complex Need Clinic (CNC) in Tallaght University Hospital Dublin, provides a multidisciplinary service to 50 children with exceptional healthcare needs. It is held twice monthly. These are often non-ambulant, and require enteral feeding. Attending the hospital logistically challenging; parents having organise time off work, transport from hospital, find parking care for other children, which can lead stress anxiety givers. In addition, European Society Paediatric...
<h3>Introduction</h3> Cerebral Palsy (CP) is a well-recognised neurodevelopmental disorder beginning in early childhood and persisting through life. CP registries from developed countries suggest its prevalence 2–3 per 1000 live births. It has consistently proven challenge to define CP, as documented by the numerous attempts. This review aimed investigate both consensus controversy surrounding definition of which currently mostly widely accepted applied. <h3>Methods</h3> A literature search...