A5018566137- Sepsis Diagnosis and Treatment
- Down syndrome and intellectual disability research
- Childhood Cancer Survivors' Quality of Life
- Neonatal and Maternal Infections
- Immunodeficiency and Autoimmune Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Pharmaceutical studies and practices
- Hearing Loss and Rehabilitation
- Palliative Care and End-of-Life Issues
- Family and Disability Support Research
- Inflammation biomarkers and pathways
- Hearing, Cochlea, Tinnitus, Genetics
- Gastrointestinal disorders and treatments
- Child and Adolescent Health
- Immune Response and Inflammation
- Celiac Disease Research and Management
- Patient Safety and Medication Errors
- Microscopic Colitis
- Prenatal Screening and Diagnostics
- Pharmaceutical Practices and Patient Outcomes
- Family Support in Illness
- Mentoring and Academic Development
- Disability Rights and Representation
- Biotin and Related Studies
- Tracheal and airway disorders
Children's Health Ireland at Crumlin
2019-2024
Tallaght University Hospital
2013-2022
Trinity College Dublin
2017-2022
Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function altered in DS therefore we examined responses CD11b Toll like receptor 4 (TLR-4), which are important cell surface markers upregulated response to Lipopolysaccharide (LPS) endotoxin, immunomodulator melatonin. Neutrophil monocyte LPS melatonin children who were clinically stable compared age-matched controls. Whole blood was...
Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram-positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist which attenuates cytokine production improves outcomes sepsis. We hypothesised that signalling may be abnormal children DS contribute their clinical phenotype....
Abstract Background Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has myriad of functions, we hypothesised that this therapeutic agent could modulate the innate system in cohort. Methods We investigated neutrophil monocyte function (CD11b, TLR4 expression flow cytometry), genes involved TLR signalling (MyD88,...
The number of children who require palliative care has been estimated to be as high 21 million globally. Delivering effective children's (CPC) services requires accurate population-level information on current and future CPC need, but quantifying need is hampered by challenges in defining the population limited available data. objective this paper summarise how defined, quantified, literature. Scoping review performed line with Joanna Briggs Institute methodology for scoping reviews...
The implementation of the multidisciplinary Down Syndrome Health Surveillance clinic at Children's Ireland Tallaght, Dublin has shown significant improvements in adherence to guidelines as well providing health promotion strategies such information on immunisations. Our project provides a framework which would be potentially emulated and used other medical conditions. reduction attendances co-ordination same-day appointments improved parental satisfaction quality care.
A mother of a 7-year-old boy with autism spectrum disorder (ASD) attends the developmental clinic. She is very concerned as her child has significant behavioural problems associated autism. done some research into alternative therapies. asks for your opinion on chelating therapy. In children ASD (patient) does pharmacological chelation therapy (intervention) improve behaviour (outcome)? Secondary sources: The Cochrane Library was searched in January 2018 terms and Chelation. One systemic...
<h3>Aim</h3> Down syndrome (DS) is one of the commonest chromosomal abnormalities with an incidence 1:444 births and highest prevalence DS in Europe being Ireland. Individuals are at increased risk developing coeliac disease (CD) compared general population (5%–10% vs. 1%). The European Society for Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) National Institute Health Care Excellence (NICE) recommend that individuals screened CD. We aimed to determine rate screening for, CD a...
<h3>Aims</h3> We report 2 cases of status dystonicus seen in our hospital 2014. Status is a rare condition with potentially life-threatening outcome. The patients’ background, clinical features, management, likely triggers, differential diagnosis and outcome discussed. <h3>Methods</h3> Review charts. existing literature. <h3>Description</h3> <i>Case1</i>:A 9-year-old female dystonic quadriparesis GMFCS class IV, intellectual disability gastrostomy feeds was admitted febrile illness...
For almost 400 years philosophers have debated the attributes necessary for “personhood” or full moral status. While some argue that defining status of children with profound intellectual disability and exceptional healthcare needs is an academic pursuit which fails to ensure their best interests are met, I believe issue warrants careful consideration. Personhood confers protection by norms, if do not status, it could be argued they holders human rights. A number criteria “Personhood” been...
<h3>Aims</h3> Research and audit activity is mandatory for Paediatric trainees with one annual the minimum expected standard. Senior support has been shown to be helpful in facilitating successful project completion. With this aim a General research workshop was established, providing supportive forum discussion advice on individual projects. This paper will describe development outomes of project. <h3>Methods</h3> An open, monthly, Consultant-supported, breakfast meeting convened junior...
<h3>Aims</h3> Down Syndrome (DS) is the most common genetic syndrome associated with abnormal immune function and defects. There an increased susceptibility to both bacterial viral infections. We aimed examine degree of immunodeficiencies in children DS. <h3>Methods</h3> Children who attended specialist multidisciplinary DS clinic Tallaght were included, medical details collected especially relation infections, recurrent respiratory tract infections (RTIs), hospital admissions vaccinations....
<h3>Background</h3> Toll like receptors (TLRs) are key in initiating innate immune responses. TLR2 is crucial recognising lipopeptides from gram positive bacteria and implicated chronic inflammation. Children with Down syndrome (DS) prone to infections these pathogens have an increased risk of autoimmunity. Sparstolonin B (SsnB) a TLR antagonist shown reduce cytokine production improve outcomes sepsis. We hypothesized that signalling may be anomalous children DS contribute their clinical...
<h3>The problem</h3> Down syndrome (DS) is the most prevalent chromosomal abnormality accounting for 8% of all registered cases in Europe. One baby with DS born out every 444 live births Ireland. Recent decades have seen a substantial increase life expectancy children DS. The implementation medical guidelines preventative health care programmes to helped improve and quality life. <h3>Aim</h3> development multidisciplinary one stop clinic provide surveillance Syndrome adherence outlined by...
<h3>Background</h3> The Complex Need Clinic (CNC) in Tallaght University Hospital Dublin, provides a multidisciplinary service to 50 children with exceptional healthcare needs. It is held twice monthly. These are often non-ambulant, and require enteral feeding. Attending the hospital logistically challenging; parents having organise time off work, transport from hospital, find parking care for other children, which can lead stress anxiety givers. In addition, European Society Paediatric...
<h3>Background and aim</h3> Palliative Care for Children is defined as 'an active total approach to care, from the point of diagnosis or recognition throughout child's life, death beyond'. It recognised that prevalence children with life-limiting conditions (LLC) increasing. In Ireland majority LLC are cared by paediatricians working in hospitals no direct access specialist paediatric palliative care(PPC) services. This study was part a learning needs assessment paediatrician's training...