A5077290847- Eosinophilic Esophagitis
- Microscopic Colitis
- Celiac Disease Research and Management
- Spondyloarthritis Studies and Treatments
- Epilepsy research and treatment
- Intestinal Malrotation and Obstruction Disorders
- Tracheal and airway disorders
- Psoriasis: Treatment and Pathogenesis
- Intensive Care Unit Cognitive Disorders
- Microtubule and mitosis dynamics
- Autoimmune and Inflammatory Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Inflammatory Bowel Disease
- Vehicle emissions and performance
- Genetic and Kidney Cyst Diseases
- Intraperitoneal and Appendiceal Malignancies
- Neurofibromatosis and Schwannoma Cases
- Mechanical Circulatory Support Devices
- Hemophilia Treatment and Research
- Micro and Nano Robotics
Children's Health Ireland at Crumlin
2012-2025
University of Pennsylvania
2023
Tallaght University Hospital
2010-2023
St. Vincent's University Hospital
2020-2023
Philadelphia University
2023
Children's Hospital of Philadelphia
2023
Maastricht University
2023
Rensselaer Polytechnic Institute
2018-2020
University College Dublin
2003-2020
New York City Department of Transportation
2019
To describe the change in incidence of paediatric inflammatory bowel disease (IBD) observed at National Centre for Paediatric Gastroenterology, Hepatology and Nutrition, to determine whether presenting phenotype outcomes have changed during past decade.The annual IBD Irish children aged <16 years was calculated 2000-2010. Two subsets patients, group A (diagnosed between 1 January 2000 31 December 2001), B 2008) were phenotyped according Paris Classification. Phenotype diagnosis 2-year...
In the presence of epidermal growth factor (EGF) and/or fibroblast 2 (FGF2), neuroepithelial precursor cells from dissociated fetal human spinal cord are mitotically active and form free-floating spheres undifferentiated cells. Proliferating were obtained in approximately 40% preparations with each mitogen, immunoreactive for intermediate filament nestin, did not express neuronal- or glial-specific markers. Early passage pluripotent differentiated into neurons expressing MAP2a,b, NF-M, TuJ1,...
Abstract Background The British Society of Gastroenterology recommend the use structured transition programmes to improve control chronic GI disease in adolescents. Although research is limited have been shown outcomes IBD {1}. Methods We performed a retrospective multicentre study In collaboration with our National Children’s Hospital. Data was collected on patients prior adult services and after they transitioned five hospitals across Ireland. Our aim look at impact attending programme...
Despite over 80 years of clinical experience with coagulation factor (F)VIII inhibitors, surprisingly little is known about the in vivo mechanism this most serious complication replacement therapy for hemophilia A. These neutralizing anti-drug alloantibodies arise ~30% patients. Inhibitor formation T cell-dependent, but events leading up to helper cell activation have been elusive due part complex anatomy and cellular makeup spleen. Here, we show that FVIII antigen presentation CD4+ cells...
The incidence of paediatric inflammatory bowel disease diagnosed before age 10 years is reportedly increasing, but national data are limited.To characterise the epidemiology, phenotype and clinical outcomes children with years, compare from aged 10-16 years.A review all Irish cases early onset (diagnosis <10 EO-IBD) presenting between January 2000 December 2014 was undertaken compared to a cohort later patients 16 LO-IBD). Diagnostic investigations, phenotype, treatments, long-term surgical...
Abstract Objectives To establish, amongst Irish rheumatic musculoskeletal disease (RMD) patients, rates of COVID-19 symptoms and positive tests, DMARD adherence attitudes to virtual clinics. Methods An online survey assessing status, RMD diagnoses, information sources was disseminated via the Arthritis Ireland website social media channels. Results There were 1381 respondents with 74.8% on immunosuppressive medication. Symptoms reported by 3.7% which 0.46% tested positive, consistent general...
Abstract Background Cyclical vomiting syndrome (CVS) is a disorder that affects all ages and characterized by episodes of severe nausea with symptom‐free intervals between episodes. The incidence in children 3.15/100 000 per year. Our objective was to evaluate the natural history CVS examine factors predict symptom resolution. Methods Thirty newly diagnosed (mean 9.15 years, SD 3.31 range 3.5–15.7) were enrolled. All had follow‐up interview at 3 months, 27/30 6 22/30 9 months. Key Results...
This study builds on the success of New York City’s protected bicycle lanes (PBLs) through improving understanding and impacts different intersection designs. Specifically, to understand better safety two primary design treatments for single direction PBLs, mixing zone fully split phase signal, several data sources are used in a before–after cross-sectional analysis including; 184 intersections, nearly 17 years reported injury crashes at historic volume turning movement counts. It was found...
Heterodimeric KIF3AC is a mammalian kinesin-2 that highly expressed in the central nervous system and associated with vesicles neurons. an intriguing member of family because intrinsic kinetics KIF3A KIF3C when as homodimers analyzed vitro are distinctively different from each other. For example, single-molecule velocities engineered KIF3AA KIF3CC 293 7.5 nm/s, respectively, whereas has velocity 186 nm/s. These results led us to hypothesize heterodimerization alters catalytic properties two...
Background:Airway management is a core competency in anesthesiology training and practice.Residents are taught how to evaluate patients identify those who may difficulty securing their airway.The ASA has devised an algorithm on of difficult airways.The conservative methods practiced throughout training.However, the default last resort obtaining invasive airway.It this potentially life-saving, procedure that residents graduate have never performed clinically.In our institution, Anesthesiology...
We described a 15-year-old- boy who presented with neurofibromatosis type 1 and Crohn’s disease. Neurofibromatosis (NF1) is the most common form of NF, affecting in 3000 individuals. disease one inflammatory bowel diseases. Its incidence significantly rising Ireland. Concomitant association NF1 rare finding. This first case reported paediatric population.
<h3>Background</h3> Small intestinal biopsy remains the reference standard for diagnosing coeliac disease (CD) in children. Recent international guidelines suggest that select patients, may not be necessary. <h3>Aims</h3> The aim of this study were to: (a) correlate serology with histology findings Irish children a high pre test probability (b) determine if proposed changes to CD diagnostic algorithm hold true an paediatric cohort. <h3>Methods</h3> A retrospective chart review all cases...
Within the first year following orthotopic heart transplantation, patient is at risk of graft failure, rejection, and infection. Late mortality often due to allograph vasculopathy. Most patients with primary failure will usually recover temporary mechanical ventricular assist support; however, on occasion must be retransplanted. For who suffers necessitating explanation bridging until a new suitable found, there are several total artificial options. However, in pediatric population these...
<h3>Aim</h3> Down syndrome (DS) is one of the commonest chromosomal abnormalities with an incidence 1:444 births and highest prevalence DS in Europe being Ireland. Individuals are at increased risk developing coeliac disease (CD) compared general population (5%–10% vs. 1%). The European Society for Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) National Institute Health Care Excellence (NICE) recommend that individuals screened CD. We aimed to determine rate screening for, CD a...
In the presence of epidermal growth factor (EGF) and/or fibroblast 2 (FGF2), neuroepithelial precursor cells from dissociated fetal human spinal cord are mitotically active and form free-floating spheres undifferentiated cells. Proliferating were obtained in approximately 40% preparations with each mitogen, immunoreactive for intermediate filament nestin, did not express neuronal- or glial-specific markers. Early passage pluripotent differentiated into neurons expressing MAP2a,b, NF-M, TuJ1,...